Verteporfin HAIR REGENERATION HUMAN TRIAL Dr. Barghouthi *OFFICIAL THREAD

[Nikoni]

@Melvin- Admin is it possible to arrange a podcast with Dr. Barghouthi after his trial ? There are so many questions. Also maybe you can arrange one also with Dr. Bloxham. I am sure these podcasts will be hits.

BTW Dr. Barghouthi said that trial date is October 24, do you know if it was done ?

[TV_on_LazerDisk]

21 hours ago, takuma said:

We next assessed the effects of multiple verteporfin doses. Treatment with two doses (POD 0 and 4) yielded healing rates, gross appearance, ECM, and EPF abundances comparable to single-dose effects (POD 0) (fig. S7). When dosage was increased to four treatments (POD 0, 4, 8, and 12), EPFs were almost fully depleted (fig. S7, D and E) but wound closure was delayed, hair regrowth was reduced, and ECM features diverged from those of unwounded skin (fig. S7, A to C). Thus, verteporfin affected wounds in a dose-dependent manner, with detrimental effects upon excessive dosing.

 

Despite scars’ excess collagen, they possess ≤80% of skin’s strength because of inferior ECM organization (26). We sought to determine whether verteporfin-induced regeneration also functionally recovered skin’s mechanical robustness. Consistent with scars’ decreased structural integrity, POD 30 control wounds had significantly reduced tensile strength (versus skin; Fig. 4I, green versus red). In contrast, verteporfin-treated wounds’ tensile strength did not significantly differ from that of unwounded skin (Fig. 4I, green versus blue), supporting restoration of unwounded-like strength (representative force-displacement/stress-strain curves, fig. S12).

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008875/

 

 

From my understanding here, when the researchers tried multiple doses it had reduced hair regeneration and too long delayed the wound closure, but im not sure if this means they tried multiple doses at once or if they tried to do so within longer time intervals ie days or weeks. But, my assumption is they spaced it out because they mentioned four treatments implying they treated the wound with verteporfin four different times in that attempt

I posted the study for reference 

 

 

I think hgh during the healing period might be an option. Should accelerate wound healing and tissue regeneration possibly hair follicles. 

[takuma]

there's something that confuses me, so when we get a hair transplant the surgeon punches tiny holes in the scalp donor region and extracts follicles and when the skin heals it leaves scar tissue which doesn't grow hair. But, the surgeon also makes incisions in the recipient area at the top of the scalp and inserts the extracted follicles into those incisions, correct. So why does the hair grow back, after all the surgeon is wounding both areas, shouldnt the skin in both areas grow back as scarred skin that is unable to grow hair from it, or am i missing something 

[victorcitolago]

There is a study that I went through not long ago and in which it was shown precisely that (the study was also done by a Spanish and an English hair surgeon) how when grafting hair into a scar, this hair follicle changed the molecular structure of the scar tissue resembling it to healthy tissue, since this follicle when it "grabbed" in the skin caused sweat glands to grow. blood vessels to provide irrigation to the new hair, sebaceous glands, etc., so this in turn transformed the scar tissue into normal tissue.

[victorcitolago]

https://www.google.com/amp/s/www.imperial.ac.uk/news/242531/scars-mended-using-transplanted-hair-follicles/amp/

[tatasabaya]

7 hours ago, takuma said:

there's something that confuses me, so when we get a hair transplant the surgeon punches tiny holes in the scalp donor region and extracts follicles and when the skin heals it leaves scar tissue which doesn't grow hair. But, the surgeon also makes incisions in the recipient area at the top of the scalp and inserts the extracted follicles into those incisions, correct. So why does the hair grow back, after all the surgeon is wounding both areas, shouldnt the skin in both areas grow back as scarred skin that is unable to grow hair from it, or am i missing something 

Because they insert the grafted healthy skin with the hair follicle. There's no "hole" left in the recipient area.

[sansi]

On 10/16/2023 at 8:04 PM, DrTBarghouthi said:

Hi guys,

Apologies for the delay. I like to process the photos myself and I couldn’t get to that yet in clinic. Nonetheless, I know most of you are waiting for some sort of update. 
I had a look at the areas and the patient and I must say I’m quite happy with how the 0.4 mg and to some extent the 0.32 mg areas have developed. The 0.4 mg I found to be nicely healed . I will share the photos ofcourse but thought at least to give some update of what I saw thus far. 

@DrTBarghouthi you are being harsh on us after such an encouraging update we haven't seen photos for two weeks already.

[sansi]

Guys why do you dislike my comment ?

I am very encouraged and want to see the photos of the healed area .

Asking for an update does not equal to disrespect and I am as grateful to Doctor Barghouthi as you. 

[Melvin- Admin]

@sansi

While I appreciate your enthusiasm. Dr. Barghouthi is well aware that people are expecting to see an update. Constantly asking him for an update isn’t going to make it happen any faster. That doesn’t mean he’s being harsh, it means he’s busy and hasn’t had the time. Patience is key.

[takuma]

So far it's two surgeons, Doctor Bargouthi and Doctor Bloxham that are actively experimenting with verteporfin on hair transplant patients, Have any other doctor's expressed interest? Does anyone know.

[tatasabaya]

14 minutes ago, takuma said:

So far it's two surgeons, Doctor Bargouthi and Doctor Bloxham that are actively experimenting with verteporfin on hair transplant patients, Have any other doctor's expressed interest? Does anyone know.

Dr. Pittella and Dr Parissis afaik. They expressed interest but that's all, no plans have been made public so far.

Edited October 31, 2023 by tatasabaya

[DrTBarghouthi]

Hi guys,

Hope you’re keeping well. Apologies for keeping you waiting again. It was a busier than usual period in the last few weeks and I just landed in India for the annual hair conference. 
As mentioned in a previous post, I continue to see the consistent difference between injected and control sites. I think the 0.4 area has been showing the best overall progress- but I also think that we do notice changes in the other doses too. The zoomed out 0.4 area looks to me untouched- but that’s only my subjective judgement. 
I was also happy to see the 0.24 mg area catching up to show better visual recovery and that might be due to the fact that this area had tumescent fluids injected in it, leading to vasoconstriction. This might be leading to a more localised effect of Verteporfin in the region. I have uploaded the photos here. 
 

 

 

 

 

 

 

 

As for future trials, I had one planned for the 24 th October, but I pushed him back because of the conference. I thought it would be important to follow him closely in the first few weeks and I didn’t want to be away in his initial recovery. We agreed to do it in November as he also has no travel commitments or difficulties with regular follow ups. We also have another patient who will be potentially having Verteporfin in November along with his procedure. 
 

I think the optimal dosing is not too far off. I am still keen on increasing the dose slightly- or at least in some areas. 
 

[piruka]

That is amazing! The 0.4T looks untouched to my eyes. Seems like it can actually regrow hairs 😲

Worth the wait, thanks for doing this. You’re a legend

[mr_peanutbutter]

27 minutes ago, DrTBarghouthi said:

Hi guys,

Hope you’re keeping well. Apologies for keeping you waiting again. It was a busier than usual period in the last few weeks and I just landed in India for the annual hair conference. 
As mentioned in a previous post, I continue to see the consistent difference between injected and control sites. I think the 0.4 area has been showing the best overall progress- but I also think that we do notice changes in the other doses too. The zoomed out 0.4 area looks to me untouched- but that’s only my subjective judgement. 
I was also happy to see the 0.24 mg area catching up to show better visual recovery and that might be due to the fact that this area had tumescent fluids injected in it, leading to vasoconstriction. This might be leading to a more localised effect of Verteporfin in the region. I have uploaded the photos here. 
 

 

 

 

 

 

 

 

As for future trials, I had one planned for the 24 th October, but I pushed him back because of the conference. I thought it would be important to follow him closely in the first few weeks and I didn’t want to be away in his initial recovery. We agreed to do it in November as he also has no travel commitments or difficulties with regular follow ups. We also have another patient who will be potentially having Verteporfin in November along with his procedure. 
 

I think the optimal dosing is not too far off. I am still keen on increasing the dose slightly- or at least in some areas. 
 

holy smoke, the difference is undeniable. big thanks for taking the risk and actually doing this DR. BARGHOUTHI!

did colleagues already approached you during the conference in india?

 

if that really world i hereby official endorse you, melvin and the donator for the nobel price in medicine

Edited November 1, 2023 by mr_peanutbutter

[Fox243]

29 minutes ago, DrTBarghouthi said:

Hi guys,

Hope you’re keeping well. Apologies for keeping you waiting again. It was a busier than usual period in the last few weeks and I just landed in India for the annual hair conference. 
As mentioned in a previous post, I continue to see the consistent difference between injected and control sites. I think the 0.4 area has been showing the best overall progress- but I also think that we do notice changes in the other doses too. The zoomed out 0.4 area looks to me untouched- but that’s only my subjective judgement. 
I was also happy to see the 0.24 mg area catching up to show better visual recovery and that might be due to the fact that this area had tumescent fluids injected in it, leading to vasoconstriction. This might be leading to a more localised effect of Verteporfin in the region. I have uploaded the photos here. 
 

 

 

 

 

 

 

 

As for future trials, I had one planned for the 24 th October, but I pushed him back because of the conference. I thought it would be important to follow him closely in the first few weeks and I didn’t want to be away in his initial recovery. We agreed to do it in November as he also has no travel commitments or difficulties with regular follow ups. We also have another patient who will be potentially having Verteporfin in November along with his procedure. 
 

I think the optimal dosing is not too far off. I am still keen on increasing the dose slightly- or at least in some areas. 
 

Dang we might be cured bois

[Gatsby]

You're doing God's work @DrTBarghouthi. 🙌💯

[Square1]

To play devil's advocate. I think that the test-site for 0.4 does not look completely untouched. To me, the density is visually lower than the part of the head above that was actually untouched. Dose optimization is still an issue it seems.

However, the test-site lacks the open holes that the control site clearly has, so the most logical outcome is that considerable regrowth has taken place. Also very positive is that this regrown hair is still here after give or take 16 months.

Fantastic that more research is in the pipeline. Does it include more scientific hair count measurements? If so, we can put a percentage on the hair it regrows and gives an benchmark for other scientists to improve upon. 

Overall, great news and many thanks again for the work of dr. Barghouthi. What percentage of regrowth do you think is achieved here?

 

 

 

 

 

[takuma]

i am absolutely floored by the 0.4T pics! wow! just amazing. 

Thank you so much Doctor Bargouthi for doing these trials @DrTBarghouthi

 

Edited November 1, 2023 by takuma

[Eli_Avdikian]

Amazing ! beyond words !

[Melvin- Admin]

Promising indeed hopefully you can speak about this at the conference @DrTBarghouthi 🙏

[takuma]

Guys, we should have a verteporfin + microneedling test done on a completely bald region on the top of the head test with verteporfin. Would be interesting if it works on completely bald areas as well. Maybe we should get a bottle on a group buy and test it

[Nikoni]

Totally worth the wait !!!

You cracked it Dr. Barghouthi from the very first attempt.

[takuma]

Apart from the hair regeneration, which is pretty obvious from the comparison, It's amazing too how there is virtually no scars in the 0.4T and 0.32T verteporfin tested area pics wow!  Even on the 0.24T test pics you can see that it looks different, less scarring. Wowowow!

Edited November 1, 2023 by takuma

[sr1486]

I’m very happy. I hope I can get a transplant with verteporfin in the next year or so 

[TorontoMan]

Exciting news, selfishly now I’d like to know if it would work on donor regions that have already been extracted from