victorcitolago

I think exactly the same, I'm not going to be like the other crazy fanboys who believe with blind faith everything the doctor says, honestly without a photo from before, this is rather of little use to me, since let's not fool ourselves, in any aesthetic treatment you look for the before and after to see if it is really worth the disbursement of money, If he doesn't show me pictures of the before, I automatically think it's because there's something to hide, and if there's something to hide, I spend the money on a leap of faith, it's simple

https://www.google.com/amp/s/www.imperial.ac.uk/news/242531/scars-mended-using-transplanted-hair-follicles/amp/

There is a study that I went through not long ago and in which it was shown precisely that (the study was also done by a Spanish and an English hair surgeon) how when grafting hair into a scar, this hair follicle changed the molecular structure of the scar tissue resembling it to healthy tissue, since this follicle when it "grabbed" in the skin caused sweat glands to grow. blood vessels to provide irrigation to the new hair, sebaceous glands, etc., so this in turn transformed the scar tissue into normal tissue.

Because I'll have to see how verteporfin works to be able to give my opinion, that is, I'm not going to give my opinion on something that I haven't seen and that I don't know either, so I'll have to follow the thread. That said, it is clear that verteporfin does something, but I don't think this is enough to continue perfecting a method, as I said yesterday, so expensive, with so much downtime, etc etc, because if it were so I think it would enhance for example the cream I used yesterday, which is easier to apply since it is a cream, It has no downtime, etc etc.

You also say that what we've seen so far is very promising, okay, but how do you prove in a healed scar that the injected verteporfin has been the culprit that the skin has healed better? Because perhaps the type of suture of the wound and how it is done also has something to do with it, since I see a stitch suture as much more professional than a staple suture, for example. To check this, you would have to make 2 cuts exactly the same, of the same diameter and in the same place, in addition to applying the same dose of verteporfin to the 2 wounds, only then would you see if with the same elements the result is different.

I don't want to give my opinion because it seems that you don't want to see reality even with everything against you: let's see, back in 2008 they discovered a topical cream called avotermin that significantly reduced scars, well, although we were doing several studies where it was clearly seen how the scars were reduced considerably, it did not pass the phase 3 trials and it remained a dead letter, I emphasize that I only said that it was a cream for topical use, therefore easier to use. I use it than verteporfin, safer, without so much downtime and cheaper, because it has still disappeared and today no one knows anything about it, so I imagine that verteporfin, having not shown 100% efficacy from the first moment, will end up happening the same. since no doctor is going to dare to cut a scar, inject verteporfin and then wait to see what happens, since for that they would have researched back in the day with the cream that at most the side effect it could cause would be irritation, but with verteporfin it has several effects that can arise: you can suture the patient badly, causing him to get a new scar and sue you, etc., so I honestly don't think this will end up going very far, sorry. How hard but it's the reality of what I see, I don't know, it was discovered in 2021 and there are very few doctors who have joined to experiment on their own, there must be a reason. The photo that I put below is the one of the cream called avotermin, as you can see it was not perfect but it worked, it worked, because even so it did not pass the phase 3 trials and until today that I bring it here it has not been talked about again, so I think that verteporfin being its method of application much more invasive and not showing 100% efficacy, I doubt that more investment will be made in it, I'm sorry because I know it's hard, but it's my opinion and what I'm afraid will end up happening.

I hope the verteporfin works 100%, since really looking at this last photo of Mr. KK I don't know if it would be worth going through everything that it entails so that it remains like this, that is, excision costs, suture costs, price of the verteporfin (which is exorbitant), apart from the fact that if you are not lucky enough to be from India or a country there, in my country for example (Spain) you can only buy it with a prescription and going to the black market is highly persecuted , apart from the fact that you get it depending on the length of the scar, the thickness, etc. you would still have to rest for a while without working, since it heals more slowly, so I would love for it to work for the complex that I have with my stretch marks, but I'm really not very optimistic about the medical path that this may have, since I don't think they will invest if all these handicaps are involved.

Firs of all, we would loke to thank @Melvin- Moderator for passing on our questions to Dr. Longaker. My question to DR. is very simple and it is if with the help of verteporfin stretch marks could also be removed, since i understand that these are still a type of scar. Greeting and thanks again to Dr melvin.

First of all i would like to apologize because as i said i am using the google translate and then i get this letter format. Please excuse me. Secondly, i don't know anything about stanford. I just sent an instagram direct to a doctor who worked there but her last post on the platform is from 2018. Therefore, i do not think he will answer.

And why did the avotermin disappear? If you see the article I passed you will realize that avotermin actually worked and 10 or 13 years later no one talks about it anymore.

Hello, first of all I would like to introduce myself and I apologize in advance for my level of English since I am from a small town in Spain and curiously I discovered this page looking for really effective treatments for my stretch marks due to my multiple gains and losses of weight. answering the last comrade and although it is a bit counterproductive for me (since it would interest me enormously if it did arrive) I will say that I honestly do not think this will get anywhere since I believe that the industry (at least in the case of stretch marks and scars) prefers to sell you multiple laser sessions, microneedling, exfoliations, etc., rather than making an incision in the place where you have the scar, as the longaker doctor already said, applying verteporfin and waiting for the skin to regenerate without leaving a trace Think about it, the losses would be millions for the companies that manufacture the lasers and for the beauty/medical centers where they sell you the sessions, now instead of 6 or 8 laser sessions to hide the scar, with only 1 small incision in the Instead of the scar, we administer verteporfin and simply wait for nature to do the rest. Look, I recently read a very, very recent article that a protein had been discovered that could regenerate teeth simply by applying it to the gums, I think I remember: do you really think that would interest dentists who live on extractions, implants, dental cleanings, fillings etc? I mean now it just doesn't matter that all your teeth have fallen out or that you have them bad, you just extract them, take the medicine and you get completely new teeth, I honestly don't think any dentist would want to prove a thing that goes against of what is giving him work and is generating thousands and thousands of euros, because with the verteporfin and the scars I think the same thing will happen. You also have the example of avotermin, where I already told you that I saw it recently and the publication date surprised me: 2008 and it already promised to heal without scars, we are in 2023 and we are still the same, and best of all, avotermin was not so as promising as verteporfin, since it did not regenerate hair follicles or sebaceous glands, but it did hide or greatly reduce the appearance of scars if it was applied right after a surgical incision, remember that this was from 2008, and no one talks about it anymore . Another case and the last one, recently a dermatologist from here in Spain realized that grafting growing hair follicles in scars, these changed and "became" normal skin at 6 months, since the implantation of the follicles in the scar caused it to create new blood vessels, glands, etc. etc., so much so that at 6 months the epidermis had doubled its thickness until it reached that of normal skin where there had never been scars before, now this doctor and his team were looking for what processes occurred when implanting these follicles in the scars to apply them to a heart after suffering a heart attack, a lung with fibrosis, etc., but they would have to do it without grafting the hair follicles, since there are none in a heart or lung, therefore this doctor does not know the use of verteporfin or does not believe in it. Trust me when I say that I would love to have this applied to my stretch marks as I think it could work as stretch marks are still just a type of scar after all and I am extremely grateful to Dr. Barghouti and his team for being pioneers in this, but I really believe that this will not go very far and in the event that it does (at least to apply in the scars sector, in the hair graft sector I don't know) it will be very late , probably when I am 50 or 60 years old, and I am currently 26, anyway I will leave this here and now I will send you the references to all the articles that I have seen so that you can see that I have not invented them, and I pray to the administrator of the page to move the topic from here if it is not the correct one. all the bes. link of avotermin: https://www.hindawi.com/journals/drp/2010/690613/ link of transplanted hair follicles in scars: https://www.google.com/amp/s/www.imperial.ac.uk/news/242531/scars-mended-using-transplanted-hair-follicles/amp/ link of verteporfin administration in scars: https://www.statnews.com/2021/04/22/scientists-unlock-key-to-scar-free-skin-healing/