Xyon Topical Dutasteride User Trial (2) - Discussion, Comments and Questions

[Kevin Mendez]

I’m all for breakthroughs of new hair loss treatments. But I’m confused as to why there is such a hefty price tag on Xyon’s topical dustasteride. Since it is only the vehicle that’s changed and they did not pay for the expensive clinical trials needed to bring a new drug to market. Which also brings me to my next point: there’s very limited data showing its efficacy. Looking on Xyon’s website it shows they did 2 tests, one was on excised human skin, and the other on a very small sample group. I understand they are a business for profit, but isn’t selling a preexisting drug with their own vehicle cream that advertises reduced risk of side effects without the proper clinical trials to back those claims, at a 10X mark up than said preexisting drug a little unethical? It seems like the anecdotal evidence is promising, but I still think the the lack of clinical data, and price is very concerning. I would love to hear more from Xyon themselves as to what justifies the price tag, and what they are doing to further the proof that what they’re selling is as advertised. 

[DedLifts]

On 10/16/2023 at 3:08 PM, HairlineHero said:

I started taking Xyon's Topical Dutasteride last week - currently applying daily as recommended by Dr. Hasson and the pharmacist 🤞.

Has anyone tried applying Xyon's Topical Dutasteride on their temple peaks or at the base of their neck, which are also common areas affected by androgenic alopecia?  It seems that people are predominately applying it on their crown, midscalp, and hairline.

I don't think it's necessary to apply at the nape. I'm only applying it to the hairline and crown, but I'm still getting thickening in other areas. Even my donor area has improved in quality.

[jim1973]

On 9/25/2023 at 2:11 PM, Melvin- Admin said:

My advice is take it 1x per week, see how you feel. If you’re good, then slowly increase the frequency by 1x per week. I believe 4-5x per week is good enough. 

@Melvin- Admin Is there a thread that you know of that already has communication related to those who prefer topical Fin to topical Dut?  (Whether Xyon brand or others?)

[Spidey]

For those who are using this. Did you read the leaflet fully? I ask this because it's clearly stated that you use it in the morning and they advise against using it at night and sleeping with it on your head/in your hair. Reason is bc it'll transfer onto your pillow and can then transfer onto your partner which is a big no no. I wonder if people with systemic sides are due to improper of cleaning their hands after use and incidentally ingesting some.  

Anyways I got my bottle today but after reading the leaflet I'm pretty deterred from starting it. The warning and side effect section of the leaflet is pretty scary. I know they have to put it on there because it's their due diligence but still it's kind of off putting 

[Spidey]

On 10/17/2023 at 7:26 PM, Kevin Mendez said:

I’m all for breakthroughs of new hair loss treatments. But I’m confused as to why there is such a hefty price tag on Xyon’s topical dustasteride. Since it is only the vehicle that’s changed and they did not pay for the expensive clinical trials needed to bring a new drug to market. Which also brings me to my next point: there’s very limited data showing its efficacy. Looking on Xyon’s website it shows they did 2 tests, one was on excised human skin, and the other on a very small sample group. I understand they are a business for profit, but isn’t selling a preexisting drug with their own vehicle cream that advertises reduced risk of side effects without the proper clinical trials to back those claims, at a 10X mark up than said preexisting drug a little unethical? It seems like the anecdotal evidence is promising, but I still think the the lack of clinical data, and price is very concerning. I would love to hear more from Xyon themselves as to what justifies the price tag, and what they are doing to further the proof that what they’re selling is as advertised. 

If you Google them you'll see there's a lot of advertising done for this product. Mind you if their delivery system does what it says it does that's a part of the reason too. 

[TRC79]

On 9/25/2023 at 12:57 PM, 4chanhue said:

Just got Xyon Topical Dut today. Packaging is super nice. Expiry on the package is 3/2024.

Expiration is now 6 month not 3? 

[Melvin- Admin]

On 11/7/2023 at 9:05 AM, TRC79 said:

Expiration is now 6 month not 3? 

Mine still says 3 months and I just received it.

[Spidey]

Mine is 6 mths. 

[Melvin- Admin]

1 hour ago, Spidey said:

Mine is 6 mths. 

I’m gonna reach our maybe they messed up on my label.

[Spidey]

Just now, Melvin- Admin said:

I’m gonna reach our maybe they messed up on my label

It's probably up to the pharmacy. At the end of the day I don't think a couple mths is going to change much of the efficacy. 

[GhostCryptid13]

So I ordered my topical duta, but I’m absolutely terrified of side effects (I had sides on microdosing topical fin). Has anyone had any side effects? Can someone explain to me why the likelihood of getting sides using this is very small?
 

I’m planning on using once a week (as instructed by Dr. Cooley)

Edited December 20, 2023 by GhostCryptid13

[hairman4321]

i've had less side effects on topical dutasteride than i had on oral finasteride, dose is important though

[mrmane85]

Is it possible to get this in Australia? 

[RisinStar]

On 12/29/2023 at 11:22 AM, mrmane85 said:

Is it possible to get this in Australia? 

They e-mailed me 6 months ago that it was only available in Canada + U.S., but that they would keep me posted when it was available it Europe (so I guess it's the same situation for Australia)

Haven't heard them anymore since them, but I really hope it comes available worldwide in 2024

[TRC79]

How's everyone doing result wise? I feel like im losing ground using topical dut 3x weekly. Still on daily minox and once weekly microneedling , my best results were on oral fin .33mg 3x daily plus minox/microneedling, but had sides. So far with xyon topical dut no noticeable sides. so frustrating considering going back to oral fin maybe .25mg, really wish you could get a fin pill at a lower dose instead of cutting because its highly in accurate.

[Melvin- Admin]

31 minutes ago, TRC79 said:

How's everyone doing result wise? I feel like im losing ground using topical dut 3x weekly. Still on daily minox and once weekly microneedling , my best results were on oral fin .33mg 3x daily plus minox/microneedling, but had sides. So far with xyon topical dut no noticeable sides. so frustrating considering going back to oral fin maybe .25mg, really wish you could get a fin pill at a lower dose instead of cutting because its highly in accurate.

Why are you only using it 3x per week?

[Hairboy67]

54 minutes ago, TRC79 said:

How's everyone doing result wise? I feel like im losing ground using topical dut 3x weekly. Still on daily minox and once weekly microneedling , my best results were on oral fin .33mg 3x daily plus minox/microneedling, but had sides. So far with xyon topical dut no noticeable sides. so frustrating considering going back to oral fin maybe .25mg, really wish you could get a fin pill at a lower dose instead of cutting because its highly in accurate.

I used the Xyon topical Dut for 6 months and also thought I lost ground. I have since gone back to using Fin and Minox daily with better looking hair caliber. 

[TRC79]

45 minutes ago, Melvin- Admin said:

Why are you only using it 3x per week?

1- mostly fear around sides

2- not wanting to use the day before or after microneedling 

3- really don't like how my hair looks with it on (are you using at night even tho instructions say not to ?)

4- will for sure at least add 1 more day and aim to get u to 5x weekly 

[TRC79]

1 hour ago, Hairboy67 said:

I used the Xyon topical Dut for 6 months and also thought I lost ground. I have since gone back to using Fin and Minox daily with better looking hair caliber. 

were you using xeon daily ? how long have you been back on fin? what dose and frequency ?

Edited April 16 by TRC79

[Hairboy67]

51 minutes ago, TRC79 said:

were you using xeon daily ? how long have you been back on fin? what dose and frequency ?

I was using topical dut 5x week for 6 months. I just felt it was not as effective as oral finasteride. I have been back on fin daily for the past 3 months. 

Edited April 16 by Hairboy67

[TRC79]

1 hour ago, Hairboy67 said:

I was using topical dut 5x week for 6 months. I just felt it was not as effective as oral finasteride. I have been back on fin daily for the past 3 months. 

3 months sounds about right to notice the difference. Ur on 1mg daily fin ? 

[arthurSam]

5 hours ago, TRC79 said:

How's everyone doing result wise? I feel like im losing ground using topical dut 3x weekly. Still on daily minox and once weekly microneedling , my best results were on oral fin .33mg 3x daily plus minox/microneedling, but had sides. So far with xyon topical dut no noticeable sides. so frustrating considering going back to oral fin maybe .25mg, really wish you could get a fin pill at a lower dose instead of cutting because its highly in accurate.

What sides ?

[TRC79]

1 hour ago, arthurSam said:

What sides ?

On fin, lower libido, still able to perform but noticeably weaker erections, and it would take while to get going. Not the end of the world but def unwanted sides.

[Melvin- Admin]

Oral finasteride is probably more effective, but also more likely to cause sides. Ive found using topical dut at least 5x per week has been effective. 

[TRC79]

12 hours ago, Melvin- Admin said:

Oral finasteride is probably more effective, but also more likely to cause sides. Ive found using topical dut at least 5x per week has been effective. 

Are u using it at night ? do u also use minoxidil ? do you separate the times you do each ?