Regular Member bigmistake Posted March 20 Regular Member Share Posted March 20 1 hour ago, Melvin- Admin said: I didn’t say he did trichophetic closure. Dr. Bisanga said it could be due to the type of closure. I said it was the same closure. He then said that sometimes how the skin overlaps one side of the strip can have hair growing through it. The pictures didn’t do anything for him. To be fair, the results on strip aren’t impressive. I think Verteporfin might be better on smaller punches like FUE. Maybe we should wait 12 month for the FUT scar to heal. The photos posted by Dr Bloxham were of the fifth or six months mark. Link to comment Share on other sites More sharing options...
DrTBarghouthi Posted March 20 Share Posted March 20 What we essentially did is try to get a very close look at the a small spot of extracted grafts and be able to confidently go back to the same exact spot. Once we defined the exact spots we wanted, I extracted a set number of grafts from it. The before and after photos were taken, even measuring the diameter of the extraction sites. All extracted grafts were checked and photographed under the microscope to check for transection- luckily none were transected. We then injected Verteporfin in several doses and took immediate after photos. I will do a serial follow up of all these areas. In order to go back to the extracted zones, we have both a marked spot using tricholab’s spot market and also SMP around the entire area of extraction to border them out from the rest of the extractions. 9 1 Dr. Taleb Barghouthi approved and recommended on the Hair Transplant Network. You can schedule a virtual consultation with me here. Contact me via WhatsApp at +962798378396 (Jordan) Social media: Facebook YouTube Twitter Instagram Link to comment Share on other sites More sharing options...
Senior Member Der3k7 Posted March 20 Senior Member Share Posted March 20 Do we expect 6-12 months in order to asses regeneration of those follicles? Similar to regular hair transplant results Link to comment Share on other sites More sharing options...
DrTBarghouthi Posted March 20 Share Posted March 20 I think we will follow up closely to see how the process is evolving in the donor. It could be 3 or 4 months for preliminary effects to show. 6 1 Dr. Taleb Barghouthi approved and recommended on the Hair Transplant Network. You can schedule a virtual consultation with me here. Contact me via WhatsApp at +962798378396 (Jordan) Social media: Facebook YouTube Twitter Instagram Link to comment Share on other sites More sharing options...
Regular Member Fox243 Posted March 20 Regular Member Share Posted March 20 3 minutes ago, DrTBarghouthi said: I think we will follow up closely to see how the process is evolving in the donor. It could be 3 or 4 months for preliminary effects to show. Are their control extractions? Link to comment Share on other sites More sharing options...
DrTBarghouthi Posted March 20 Share Posted March 20 The entire area is a control (apart from these 4 tested spots). 6 Dr. Taleb Barghouthi approved and recommended on the Hair Transplant Network. You can schedule a virtual consultation with me here. Contact me via WhatsApp at +962798378396 (Jordan) Social media: Facebook YouTube Twitter Instagram Link to comment Share on other sites More sharing options...
Regular Member bigmistake Posted March 21 Regular Member Share Posted March 21 14 hours ago, Fox243 said: Anyways, this is it lads. We'll finally know whether it works or not. No matter the end result, I'd like to commend Dr. Barghouthi for at least trying this out, spending hundreds of hours researching, learning how to use the trichoscope, and performing this procedure. One day, one way or the other, be it verteporfin or something else, only through courageous experiments like this will we find the cure. Wont we know if it works or not from Dr Bloxhams trial ? Link to comment Share on other sites More sharing options...
Regular Member Rasputin Posted March 21 Regular Member Share Posted March 21 18 hours ago, Melvin- Admin said: I didn’t say he did trichophetic closure. Dr. Bisanga said it could be due to the type of closure. I said it was the same closure. He then said that sometimes how the skin overlaps one side of the strip can have hair growing through it. The pictures didn’t do anything for him. To be fair, the results on strip aren’t impressive. I think Verteporfin might be better on smaller punches like FUE. That's also one point that should be studied, why does it seems that Verteporfin works better on FUE than FUT. Sure, the wound is smaller, but in the trial on pigs, the scar that regenerated skin and hair was quite large and it worked just fine. Link to comment Share on other sites More sharing options...
Regular Member xhomer Posted March 21 Regular Member Share Posted March 21 1 hour ago, DrTBarghouthi said: Sorry for the confusion. I meant the mid part of the donor area scalp. @DrTBarghouthiNew trials are not going to include also injecting verteporfin in recipient area? It will be nice if you can test in recipient area in empty area to see if it promotes growth and in recipient transplanted area after HT to see if it helps with redness/recovery/shock loss reduction Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted March 21 Author Administrators Share Posted March 21 3 hours ago, Rasputin said: That's also one point that should be studied, why does it seems that Verteporfin works better on FUE than FUT. Sure, the wound is smaller, but in the trial on pigs, the scar that regenerated skin and hair was quite large and it worked just fine. Im no scientist, but my speculation is its less scar inhibition. Verteporfin works by blocking the Engrailed-1 fibroblast pathway. It may be easier to block this pathway if the wound is smaller. That’s my theory. But again, im no scientist. I’m a paid admin for Hair Transplant Network. I do not receive any compensation from any clinic. My comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Regular Member Fox243 Posted March 22 Regular Member Share Posted March 22 Honestly wish I could fast forward 6 months to see Dr. Barghouthi's results lol. 5 Link to comment Share on other sites More sharing options...
Regular Member Dragonsphere Posted March 22 Regular Member Share Posted March 22 (edited) 1 hour ago, Fox243 said: Honestly wish I could fast forward 6 months to see Dr. Barghouthi's results lol. I was watching one of the Alien movies today and thinking something similar. If only I could put myself in a cryopreservation pod for 6 months. 🥲 One thing I think that needs to be brought to the forefront is if verteporfin could be used multiple times in the same location which would be an ultimate cure, regardless of what the regeneration rate is. (As long as there is some regeneration) Fue scarring is uniform so I imagine it is really just a percentage game as to wether scarring or regeneration happens each time. Let’s say the .4 dose yield a 50% regeneration rate and you do a 2000 graft FUE. 1000 grafts are regenerated with the remainder being scar tissue. You then do a second round punching into the remaining scar tissue only. This would result in 500 grafts being regenerated, so on and so forth. This isn’t at all far fetched as we can safely conclude the drug works in some capacity, we just don’t know how the exact regeneration rate as well as several other factors. It would literally mean you could, with multiple procedures spanning over several years, go from Patrick Stewart to Brad Pitt. Edited March 22 by Dragonsphere 2 Link to comment Share on other sites More sharing options...
Regular Member bigmistake Posted March 22 Regular Member Share Posted March 22 4 hours ago, Dragonsphere said: I was watching one of the Alien movies today and thinking something similar. If only I could put myself in a cryopreservation pod for 6 months. 🥲 One thing I think that needs to be brought to the forefront is if verteporfin could be used multiple times in the same location which would be an ultimate cure, regardless of what the regeneration rate is. (As long as there is some regeneration) Fue scarring is uniform so I imagine it is really just a percentage game as to wether scarring or regeneration happens each time. Let’s say the .4 dose yield a 50% regeneration rate and you do a 2000 graft FUE. 1000 grafts are regenerated with the remainder being scar tissue. You then do a second round punching into the remaining scar tissue only. This would result in 500 grafts being regenerated, so on and so forth. This isn’t at all far fetched as we can safely conclude the drug works in some capacity, we just don’t know how the exact regeneration rate as well as several other factors. It would literally mean you could, with multiple procedures spanning over several years, go from Patrick Stewart to Brad Pitt. FUE without scarring and without regeneration will also be a game changer. Imagine if someone has retrograde alopecia, that person can have a transplant without worrying about his scars being exposed if those hair thin out. Link to comment Share on other sites More sharing options...
Regular Member Jonathan Posted March 23 Regular Member Share Posted March 23 On 3/20/2024 at 5:06 PM, DrTBarghouthi said: I think we will follow up closely to see how the process is evolving in the donor. It could be 3 or 4 months for preliminary effects to show. Thanks Dr B, see you in June/july! Link to comment Share on other sites More sharing options...
Regular Member Nikoni Posted March 23 Regular Member Share Posted March 23 great updates lately ! @Killian How's the healing going ? Don't you mind to share a photo ? Link to comment Share on other sites More sharing options...
DrTBarghouthi Posted March 25 Share Posted March 25 Areas marked 35: 0.4 mg Verteporfin Areas marked 36: 0.6 mg Verteporfin Areas marked 37: 0.8 mg Verteporfin Areas marked 38: 1 mg Verteporfin Hi guys, Just wanted to share some photos of the latest trial. We have marked the areas injected both using a spot measure and also Scalp Micropigmentation. 7-8 follicles were removed from each marked area within the actual boundaries of the SMP. The removed grafts were all inspected and there were no transections seen. 0.4 mg Verteporfin (Before and after injection immediately) 0.6 mg Verteporfin (Before and after injection immediately) 0.8 mg Verteporfin (Before and after injection immediately) 1 mg Verteporfin (Before and after injection immediately) 12 3 2 Dr. Taleb Barghouthi approved and recommended on the Hair Transplant Network. You can schedule a virtual consultation with me here. Contact me via WhatsApp at +962798378396 (Jordan) Social media: Facebook YouTube Twitter Instagram Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted March 25 Author Administrators Share Posted March 25 4 minutes ago, DrTBarghouthi said: Areas marked 35: 0.4 mg Verteporfin Areas marked 36: 0.6 mg Verteporfin Areas marked 37: 0.8 mg Verteporfin Areas marked 38: 1 mg Verteporfin Hi guys, Just wanted to share some photos of the latest trial. We have marked the areas injected both using a spot measure and also Scalp Micropigmentation. 7-8 follicles were removed from each marked area within the actual boundaries of the SMP. The removed grafts were all inspected and there were no transections seen. 0.4 mg Verteporfin (Before and after injection immediately) 0.6 mg Verteporfin (Before and after injection immediately) 0.8 mg Verteporfin (Before and after injection immediately) 1 mg Verteporfin (Before and after injection immediately) The 🐐 amazing 🤩 1 I’m a paid admin for Hair Transplant Network. I do not receive any compensation from any clinic. My comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Regular Member Tonyyy Posted March 25 Regular Member Share Posted March 25 Great job @DrTBarghouthi, are you ready to do it with the old FUE scars, i can't wait to know, thanks again for your efforts all this time 🙏 2 Link to comment Share on other sites More sharing options...
Regular Member sansi Posted March 25 Regular Member Share Posted March 25 1 hour ago, DrTBarghouthi said: Areas marked 35: 0.4 mg Verteporfin Areas marked 36: 0.6 mg Verteporfin Areas marked 37: 0.8 mg Verteporfin Areas marked 38: 1 mg Verteporfin Hi guys, Just wanted to share some photos of the latest trial. We have marked the areas injected both using a spot measure and also Scalp Micropigmentation. 7-8 follicles were removed from each marked area within the actual boundaries of the SMP. The removed grafts were all inspected and there were no transections seen. 0.4 mg Verteporfin (Before and after injection immediately) 0.6 mg Verteporfin (Before and after injection immediately) 0.8 mg Verteporfin (Before and after injection immediately) 1 mg Verteporfin (Before and after injection immediately) Thank you Doctor for the awesome job you do ! May I ask what is the punch size used ? How many follicles were originally in the marked areas ? 1 Link to comment Share on other sites More sharing options...
Regular Member takuma Posted March 25 Regular Member Share Posted March 25 2 hours ago, DrTBarghouthi said: Areas marked 35: 0.4 mg Verteporfin Areas marked 36: 0.6 mg Verteporfin Areas marked 37: 0.8 mg Verteporfin Areas marked 38: 1 mg Verteporfin Hi guys, Just wanted to share some photos of the latest trial. We have marked the areas injected both using a spot measure and also Scalp Micropigmentation. 7-8 follicles were removed from each marked area within the actual boundaries of the SMP. The removed grafts were all inspected and there were no transections seen. 0.4 mg Verteporfin (Before and after injection immediately) 0.6 mg Verteporfin (Before and after injection immediately) 0.8 mg Verteporfin (Before and after injection immediately) 1 mg Verteporfin (Before and after injection immediately) This is amazing work! thank you Dr Bargouthi! can't wait to see how the different verteporfin concentration areas heal up and the results of the trial Link to comment Share on other sites More sharing options...
Regular Member tatasabaya Posted March 25 Regular Member Share Posted March 25 1 hour ago, sansi said: Thank you Doctor for the awesome job you do ! May I ask what is the punch size used ? How many follicles were originally in the marked areas ? It's all written right there in each pic Link to comment Share on other sites More sharing options...
Regular Member sansi Posted March 25 Regular Member Share Posted March 25 14 minutes ago, tatasabaya said: It's all written right there in each pic That's wound size and number of FUE per cm2. I'm asking about used punch size and total number of follicles in marked area, so we may know what % of follicles were extracted. Link to comment Share on other sites More sharing options...
Regular Member tatasabaya Posted March 25 Regular Member Share Posted March 25 4 minutes ago, sansi said: That's wound size and number of FUE per cm2. I'm asking about used punch size and total number of follicles in marked area, so we may know what % of follicles were extracted. My bad then 1 Link to comment Share on other sites More sharing options...
Senior Member Der3k7 Posted March 25 Senior Member Share Posted March 25 Yeah, was only the extraction density measured or was the total follicle density before or after also measured too? in order to calculate regeneration rate we would need at least the before or after absolute follicle density too so then we can compare to the follicle density 3, 6, 9 months from now and see how much of the extracted density was regenerated. 1 Link to comment Share on other sites More sharing options...
Regular Member bigmistake Posted March 26 Regular Member Share Posted March 26 13 hours ago, DrTBarghouthi said: Areas marked 35: 0.4 mg Verteporfin Areas marked 36: 0.6 mg Verteporfin Areas marked 37: 0.8 mg Verteporfin Areas marked 38: 1 mg Verteporfin Hi guys, Just wanted to share some photos of the latest trial. We have marked the areas injected both using a spot measure and also Scalp Micropigmentation. 7-8 follicles were removed from each marked area within the actual boundaries of the SMP. The removed grafts were all inspected and there were no transections seen. 0.4 mg Verteporfin (Before and after injection immediately) 0.6 mg Verteporfin (Before and after injection immediately) 0.8 mg Verteporfin (Before and after injection immediately) 1 mg Verteporfin (Before and after injection immediately) @DrTBarghouthi I hope your hard work pays off. Can you tell us total number of grafts extracted and number of excursions in which verteporfin was injected ? Link to comment Share on other sites More sharing options...
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