duchaine

Bruno. Stop

Mice.

Thaks for answer. I'm asking because I'm one week out and a) trasnpalted hair grow at a slower rate than native; b) some th are like "black head" (the FU didn't grow at all).

I can see that his native hair a little longer than transplanted hair and some TH are not grown at all (they look like black heads). It is ok or that means that the tranplanted FU are going to die?

I quoted the research. If you google metformin hair loss pubmed autophagy you will find several sere aches. Anyway, the statement that autophagy increases hair growth makes senso if you only consider that autophagy id the key for a young skin.

Wow, great result! I am so jealous you took only 2 months for a such incredible transformation!

thecnically you can achieve only 50/60 grafts per sqcm while native UF are 100/sq cm Anyway, consider that native hair in the front line are almost all singles while the trasnpalted hair are multiples. So, the number of hair per sq cm can be the same, despite the fact that the number of FU is lower.

yes, I read that posts. It is a very complex puzzles: consider that MET reduces b12 absorption and it could decrease estrogen levels if I'm not wrong. this is why I'm not taking met at the moment.

scary!!!!!

I was reading some papers about type II diabetes and metformin when I read some interesting researches about autopaghy and hair loss. Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or dysfunctional components, allowing the orderly degradation and recycling of cellular component. during the last decades, we have had several researches on AF and the benefits correlated to AF (on this topic, I suggest to read the book written by David Sinclair where he explain the results of his decennial research on this topic at Harvard University). In 2016, Matsumura et al. demonstrated that "that hair follicle stem cell aging causes the stepwise miniaturization of hair follicles and eventual hair loss in a process that that depended on the proteolysis of type XVII collagen. The cyclic growth and shedding of hair requires a complex communication between epithelial and mesenchymal cells. While autophagy is active in hair keratinocytes and mesenchymal cells surrounding hair follicles. A 2018 research (Parodi et Al.) showed that "genetic inhibition of follicular autophagy induces premature catagen and enhances hair matrix keratinocyte apoptosis, suggesting that autophagic flux in the anagen hair matrix is important for the maintenance of this stage. Indeed, we find that the principal ingredients of a product used to treat hair loss induces autophagy in organ-cultured human scalp HFs and promotes anagen. We conclude that organ-cultured human HFs are a suitable (mini-)organ system to study both the role of autophagy in human physiology ex vivo and to test candidate agents that modulate autophagy under clinically relevant conditions". So, the interesting question was, "if we do activate autophagy, can we stimulate anagen?" In 2019, Chin et al answered to this question "quiescent (telogen) hair follicles can be stimulated to initiate anagen and hair growth by small molecules that activate autophagy, including the metabolites α-ketoglutarate (α-KG) and α-ketobutyrate (α-KB), and the prescription drugs rapamycin and metformin, which impinge on mTOR and AMPK signaling. Stimulation of hair growth by these agents is blocked by specific autophagy inhibitors, suggesting a mechanistic link between autophagy and hair regeneration. Consistently, increased autophagy is detected upon anagen entry during the natural hair follicle cycle, and oral α-KB prevents hair loss in aged mice". Unluckily, the last research was conducted on aged mice. Can we stimulate hair growth taking metformin? Or, considering that fasting stimulates AF, can it be a weapon to fight hair loss?

my suggestion is: study and design your hairline several times during the weeks before your HT. Take the pics. Choose the ones you like. Show the pics to your doc. Discuss with him. Let him make the changes he things are needed.

I have thin hair so a, when they are longer than 12 cm, a little wind mess they up! anyway, they usually fall on the front and all the bald spot are clearly visible!

Ok, epic win!

There are several researches on this topic. SP ability to reduce DHT in humans is very controversial. Some papers report that SP efficacy is about 1/3 compared to finasteride while others claim that SP as no efficacy at all ("In addition, in a 7 day human clinical trial, finasteride, but not Permixon or placebo, decreased serum DHT in men, further confirming the lack of 5 alpha reductase inhibition by Permixon"). Anyway, some authors suggest that SP can improve hair growth via a DHT indigent mechanism (for ex., "LSESr promoted the hair regeneration and repair of hair loss mouse models by activating TGF-β signaling and mitochondrial signaling pathway"). Since 3 days, I've taking fina e saw palmetto. I'm not feeling any side (If I have to be honest, I can feel my libido increased). I'll keep you updated!

What do you mean?

From what I understand, the frequency and the needle size are inversely proportional. The bigger the needle, the less frequently you can have the treatment and viceversa. How big is your needle? (I think it sounds like a strange question...at least in Italian it sounds like a strange question!)

an HT for a n2/3 is something like a good haircut. The big difference is that is mora "stable": you do not look shitty because wind or sweeting.

Serkan is a dermatologist. He does nothing except hairline design. Hair. loss mentor made a video on his clinic. You can find a lot of sermon results on Italian forum and on facebook "esperienza trapianto capelli in Turchia". Some are good (15%), others are average §(the great part) and some don't fit my taste at all.

3400??? only???? OMG I think you are taking any kind of medicine that improved your baldness because it is almost impossible to get that result using only 3400 grafts

"I stopped minoxidil because I didn't see results" BiG MISTAKE! Minoxidil requires several months (and sometimes more than 2ml daily) to show his results. Considering you are balding in the crown/middle scalp and you say that your donor is weak, I would try fina. I would give a try, in your specific casse, to PRP and dermorolling.

"around 4000 I think". Didn't the doc tell you the number of graft? Where did you get your HT? Considering the area is about 45/50 cm2, it is hard to believe you got 4000UF. considering an average 50 UF/cm2 (but, from you pic, I think they are less), it is about 2500.

I see a better distribution of his hair but I don't see 4500 UF. Has he been using anything to block hair loss between the 2 procedures?

Hair for sure. Anyway, I try to buy cost effective and proven stuffs. If something has not much evidence to support his utility, I can give a try if it is not ultra-expensive

if you don't care about price, you should look worldwide. In turkey there are some amazing docs (laser, hlc, Pekiner). Anyway, you have other great docs alla around the world.

I'm waiting his mail for laser cap too!