Official CosmeRNA User Thread

[Follicle1984]

On 7/18/2023 at 12:15 AM, arthurSam said:

Hello,

I am 47yo

I got a HT last year and got a shock loss but my hair regrowed later. After that I was a lttle hair loss on shower every day (10-15 hairs).

So for stabilization, I tried topical finasteride 3x/week 0.025% 1ml with alcool. My hair loss stopped but I got sides 4-5 months later. So I needed to stop it.

Then, I tried with trichosol but same thing.

Then, I tried with liposomal + sicicone (Xyon gel bought at parati pharmacia) with 2% but same thing.

Then I tried Xyon Dutasteride at 1% but same things.

I tried also oral minox 1mg/day but got sides (heart and renal problems - saw after a blood test of renal filtration rate wich has diminished). So I stopped oral minox and no problems anymore then (my renal filtration rate is now normal).

Now I am on fluridil + cosmerna since 2,5 months (with topical minox 5% at morning too from a while now) and it works great (no hair loss anymore on shower). I got just little side (no morning wood) for few day (1 or 2) after the day of application of CosmeRNA.

I take vitamins too + zinc.

It seems I am very responsive to sides from topical medication, perhaps because I got a atopic skin.

Hi Arthur Sam.

Can I ask do you apply cosmerna every week or every 2 weeks?

Also...thanks for sharing your encouraging story. I too had awful sides from fin (both oral and topical) which has made me very nervous to even try topical dut. I figure I may give cosme a go...afew people stating its stopped their shedding. I'm shedding badly at the moment. So would be nice to have something to at least stabilise my loss.

I presume still no side effects with cosme?

Thanks

[arthurSam]

4 hours ago, Follicle1984 said:

Hi Arthur Sam.

Can I ask do you apply cosmerna every week or every 2 weeks?

Also...thanks for sharing your encouraging story. I too had awful sides from fin (both oral and topical) which has made me very nervous to even try topical dut. I figure I may give cosme a go...afew people stating its stopped their shedding. I'm shedding badly at the moment. So would be nice to have something to at least stabilise my loss.

I presume still no side effects with cosme?

Thanks

Hi,

I apply it every 2 week but if i was rich enough i would do it every week like in the research paper...

You could try cosmeRNA for sure I hope it will stop your hair loss...

Concerning sides, I still have small discomforts and prostate-type pain but since I stopped finasteride it's much lighter. I don't think the fact that I take CosmeRNA + Fluridil maintains these pains but I'm not sure either... It's hard to know... I am followed by urologists but things are progressing very very slowly...

Edited July 24, 2023 by arthurSam

[Follicle1984]

1 hour ago, arthurSam said:

Hi,

I apply it every 2 week but if i was rich enough i would do it every week like in the research paper...

You could try cosmeRNA for sure I hope it will stop your hair loss...

Concerning sides, I still have small discomforts and prostate-type pain but since I stopped finasteride it's much lighter. I don't think the fact that I take CosmeRNA + Fluridil maintains these pains but I'm not sure either... It's hard to know... I am followed by urologists but things are progressing very very slowly...

But no Erectile dysfunction on cosme?

[arthurSam]

15 minutes ago, Follicle1984 said:

But no Erectile dysfunction on cosme?

No but even with fina I was not concerned by that.

[Follicle1984]

7 minutes ago, arthurSam said:

No but even with fina I was not concerned by that.

Ah OK. Thanks for clarification.

Good you are working with a urologist I guess then. I'm glad cosme seems not to be giving you sides.

The study from dermatest supposedly showed better results with twice weekly anyway so maybe no better than weekly. I think pairing it with an androgen receptor antagonist seems a good idea.

[arthurSam]

7 minutes ago, Follicle1984 said:

I think pairing it with an androgen receptor antagonist seems a good idea.

Yes I think too. I cannot take topical minox 2x/day anymore because I cannot apply any based water product with fluridil. So now I take only topical 1x/day at morning and fluridil at night. When I take cosmerna I take  nothing else for 24h.

I tried to take 0.5mg of oral minox added to the topical but I cannot tolerate oral minox even at a such low dose.

[Follicle1984]

7 minutes ago, arthurSam said:

Yes I think too. I cannot take topical minox 2x/day anymore because I cannot apply any based water product with fluridil. So now I take only topical 1x/day at morning and fluridil at night. When I take cosmerna I take  nothing else for 24h.

I tried to take 0.5mg of oral minox added to the topical but I cannot tolerate oral minox even at a such low dose.

It's a tricky one isn't it.

I recently had some ED with alfatradiol too. I was reading into it. Turns out although 17alpha E2 is a weak estrogen in many tissues it can apparently act as a stronger estrogen in some other tissues...one being the brain. Which actually makes sense with me.

Just have to find out what works for each of us i guess.

[Follicle1984]

Anyone with any updates on cosmerna?

[Joseph James]

On 7/19/2023 at 12:28 AM, Follicle1984 said:

How you getting on with cosmerna?

I stopped taking it after the second dose. I used the full recommend dose the first time I took it, and the next day I had irritability/ anxiety similar to when I took finasteride, but not as bad. Tried it again 2 weeks later with a much lower dose, but still had the same thing, though not as severe so I stopped.

[Follicle1984]

5 hours ago, Joseph James said:

I stopped taking it after the second dose. I used the full recommend dose the first time I took it, and the next day I had irritability/ anxiety similar to when I took finasteride, but not as bad. Tried it again 2 weeks later with a much lower dose, but still had the same thing, though not as severe so I stopped.

Thanks for sharing.

Not discrediting your experience...but do you think there is a chance this may have been nocebo? After all, the mechanism this works by, causing reduction of the AR, should take a little time to come into play and equally take some time to rectify and rebuild levels of AR. If the symptoms came quickly and left quickly, it does make wonder if this MAY have been unrelated. 

The mind is a powerful thing after all.

[Joseph James]

2 minutes ago, Follicle1984 said:

Thanks for sharing.

Not discrediting your experience...but do you think there is a chance this may have been nocebo? After all, the mechanism this works by, causing reduction of the AR, should take a little time to come into play and equally take some time to rectify and rebuild levels of AR. If the symptoms came quickly and left quickly, it does make wonder if this MAY have been unrelated. 

The mind is a powerful thing after all.

That is possible, or it may have had an interaction with the blood pressure medication I take. A hair transplant surgeon seemed to think that might explain my negative experience with finasteride.

[Follicle1984]

15 minutes ago, Joseph James said:

That is possible, or it may have had an interaction with the blood pressure medication I take. A hair transplant surgeon seemed to think that might explain my negative experience with finasteride.

That interesting. I've begun to wonder if finasteride and 5AR sexual side effects may possibly be related to insulin resistance, metabolic syndrome and endothelial dysfunction. 

Some evidence that dutasteride mesotherapy is less effective in insulin resistance also.

[Joseph James]

5 minutes ago, Follicle1984 said:

That interesting. I've begun to wonder if finasteride and 5AR sexual side effects may possibly be related to insulin resistance, metabolic syndrome and endothelial dysfunction. 

Some evidence that dutasteride mesotherapy is less effective in insulin resistance also.

You may be into something with that. I'm glad we have intelligent people like yourself in this forum.

[Follicle1984]

2 minutes ago, Joseph James said:

You may be into something with that. I'm glad we have intelligent people like yourself in this forum.

Why thank you 😊  I try my best.

Well I've come across one or two people who are more intelligent than myself with regards to metabolic chemistry...and there are some interesting hypotheses withbregards to how there may be alot of other things at play and interlinking with the androgen paradox. 

When I stopped to think about it all, I realised perhaps my finasteride side effects may relate to my overall health more than i cared at first to beleive. I think the issue is aswell with insulin resistance is that it can be hard to diagnose. Needing fasting insulin levels and not simply fasting sugars. And if this is out of whack it could cause a whole host of issues. 

I'm on a mission to clean up my metabolic chemistry at the moment.

[arthurSam]

On 8/3/2023 at 12:29 AM, Follicle1984 said:

Anyone with any updates on cosmerna?

Good morning,

I continue to use it I did my 5th dose last Wednesday. I'm taking Fluridil alongside (and topical minox which I've been taking for 25 years) and the Fluridil + CosmeRNA + topical minox combo is still working great so far. I don't see any more hair falling out in the shower or styling 🙂 I hope this stabilization will continue, especially next autumn season...

On the other hand, no regrowth but given my age (47 years old) I do not expect to have any! I had seen a study (on Asians so maybe it's different for Caucasians) which said that regrowth under fina 1mg only affects 3-4% of 41-60 year olds while they affect about 10% 18-41 year olds. In addition, regrowth is in very specific places on the scalp for 41-60 year olds, whereas it occurs in several places for 18-41 year olds.

Otherwise, in terms of side effects, I now always have my erections during the night after applying CosmeRNA... everything is normal. Before I had no erections for 1-2 days after application but now no more problems.

When I apply CosmeRNA on Wednesday morning I don't apply anything else for 24 hours and I don't even shower in the evening. I apply it with a pipette 1mg all over my skull and I massage with gloves for a few minutes. I do the same procedure with Fluridil, which I apply every evening around 8 p.m. and leave on overnight. I use a pipette too for minoxidil.

Sometimes I have an itchy or burning scalp, but that usually passes. When this does not pass, I skip an application of Fluridil and everything is back to normal (I think that Fluridil attacks the scalp quite a bit because it is very heavy in alcohol...) However, I only had this problem 2-3 times since I started a little less than 3 months ago now.

CosmeRNA remains expensive I hope that over time the price will come down. They do, however, give 10% discounts when signing up and offer 15% for subsequent purchases. Better than nothing !

I can't wait for Xyon to set up in Europe because I would like to take stock with one of their dermatologists. For the future if my combo no longer works I would have liked to test topical dutasteride...

For the moment I'm really happy with my combo, and once again I really hope that my falls will not resume...

On the other hand, I continue to have problems of the prostatic type (pain in the penis, in the scrotum, etc.) and I saw a specialist in the pudental nerve who is going to give me an infiltration next October to check if my problems come from this nerve. I had an MRI and others tests to check my prostate and everything is fine there. These problems appeared after I took topical finasterides 0.025% 3x/week after 4 months last winter. Since I stopped the fina - it's been about 5 months now - it's getting better and better but it's not completely cured yet... Afterwards I don't know if it's the fina or hasard ...

Maybe Fluridil and CosmeRNA continue to maintain these symptoms, I'm not sure...

Edited August 6, 2023 by arthurSam

[Melvin- Admin]

On 8/6/2023 at 7:34 AM, arthurSam said:

Good morning,

I continue to use it I did my 5th dose last Wednesday. I'm taking Fluridil alongside (and topical minox which I've been taking for 25 years) and the Fluridil + CosmeRNA + topical minox combo is still working great so far. I don't see any more hair falling out in the shower or styling 🙂 I hope this stabilization will continue, especially next autumn season...

On the other hand, no regrowth but given my age (47 years old) I do not expect to have any! I had seen a study (on Asians so maybe it's different for Caucasians) which said that regrowth under fina 1mg only affects 3-4% of 41-60 year olds while they affect about 10% 18-41 year olds. In addition, regrowth is in very specific places on the scalp for 41-60 year olds, whereas it occurs in several places for 18-41 year olds.

Otherwise, in terms of side effects, I now always have my erections during the night after applying CosmeRNA... everything is normal. Before I had no erections for 1-2 days after application but now no more problems.

When I apply CosmeRNA on Wednesday morning I don't apply anything else for 24 hours and I don't even shower in the evening. I apply it with a pipette 1mg all over my skull and I massage with gloves for a few minutes. I do the same procedure with Fluridil, which I apply every evening around 8 p.m. and leave on overnight. I use a pipette too for minoxidil.

Sometimes I have an itchy or burning scalp, but that usually passes. When this does not pass, I skip an application of Fluridil and everything is back to normal (I think that Fluridil attacks the scalp quite a bit because it is very heavy in alcohol...) However, I only had this problem 2-3 times since I started a little less than 3 months ago now.

CosmeRNA remains expensive I hope that over time the price will come down. They do, however, give 10% discounts when signing up and offer 15% for subsequent purchases. Better than nothing !

I can't wait for Xyon to set up in Europe because I would like to take stock with one of their dermatologists. For the future if my combo no longer works I would have liked to test topical dutasteride...

For the moment I'm really happy with my combo, and once again I really hope that my falls will not resume...

On the other hand, I continue to have problems of the prostatic type (pain in the penis, in the scrotum, etc.) and I saw a specialist in the pudental nerve who is going to give me an infiltration next October to check if my problems come from this nerve. I had an MRI and others tests to check my prostate and everything is fine there. These problems appeared after I took topical finasterides 0.025% 3x/week after 4 months last winter. Since I stopped the fina - it's been about 5 months now - it's getting better and better but it's not completely cured yet... Afterwards I don't know if it's the fina or hasard ...

Maybe Fluridil and CosmeRNA continue to maintain these symptoms, I'm not sure...

Can you share any pictures? I’m thinking of giving it a shot

[arthurSam]

3 hours ago, Melvin- Moderator said:

Can you share any pictures? I’m thinking of giving it a shot

I don't have any photos that show regrowth so nothing exceptional to show. It's just that I no longer have any hair falling out in the shower or styling...

I look forward to the next few months especially October-November when the falls are more important to see if my hair will continue to stabilize...

[arthurSam]

New problem with CosmeRNA :

 

 

Edited August 16, 2023 by arthurSam

[FUEtile]

On 8/16/2023 at 2:30 AM, arthurSam said:

New problem with CosmeRNA :

 

 

I mean is that a big problem? It’s 0.4 difference. I guarantee most companies do this. Even protein powders come half empty. This company is attacked a lot. 

[Follicle1984]

10 hours ago, FUEtile said:

I mean is that a big problem? It’s 0.4 difference. I guarantee most companies do this. Even protein powders come half empty. This company is attacked a lot. 

Well on a positive note that poster on reddit says he was actually happy with the product and it seems to have halted his hairloss. Obviously being underdosed is not good...but other than that. It does seem I'm reading some good things in various places about cosmerna and that it is stopping shedding in some people. Which is perhaps all we could ask for in these early months.

I've now started to use it. Second application in. Nothing to note yet. Shedding appears the same. I'm using afew other things though too. But this is the new player, so I think any changes will largely be attributable to this.

[Follicle1984]

On 8/16/2023 at 10:30 AM, arthurSam said:

New problem with CosmeRNA :

 

 

Can I ask you Arthursam...how long before you noticed a reduced shed on cosmerna?

[Melvin- Admin]

I wanted to let the community know that CosmeRNA reached out to me. I have asked for a phone call to discuss some of these issues. My hope is that someone can join a podcast to talk about some of these concerns. 

[Follicle1984]

19 hours ago, Melvin- Moderator said:

I wanted to let the community know that CosmeRNA reached out to me. I have asked for a phone call to discuss some of these issues. My hope is that someone can join a podcast to talk about some of these concerns. 

Hi Melvin,

I don't think I'd be free to join the call but I'd be happy to list afew questions you could consider asking. Happy to private message them to you if you like.

 

 

[helpthisguypls]

On 8/22/2023 at 4:15 PM, Melvin- Moderator said:

I wanted to let the community know that CosmeRNA reached out to me. I have asked for a phone call to discuss some of these issues. My hope is that someone can join a podcast to talk about some of these concerns. 

Please do! Would love this soooo much

[FUEtile]

Any update on the podcast?