Follicle1984

Hi Can you update us about your results with regenera activa? I am considering it as I have few options. Anyone else had this and able to comment? Thanks

Hi Melvin, I don't think I'd be free to join the call but I'd be happy to list afew questions you could consider asking. Happy to private message them to you if you like.

Can I ask you Arthursam...how long before you noticed a reduced shed on cosmerna?

Well on a positive note that poster on reddit says he was actually happy with the product and it seems to have halted his hairloss. Obviously being underdosed is not good...but other than that. It does seem I'm reading some good things in various places about cosmerna and that it is stopping shedding in some people. Which is perhaps all we could ask for in these early months. I've now started to use it. Second application in. Nothing to note yet. Shedding appears the same. I'm using afew other things though too. But this is the new player, so I think any changes will largely be attributable to this.

Why thank you 😊 I try my best. Well I've come across one or two people who are more intelligent than myself with regards to metabolic chemistry...and there are some interesting hypotheses withbregards to how there may be alot of other things at play and interlinking with the androgen paradox. When I stopped to think about it all, I realised perhaps my finasteride side effects may relate to my overall health more than i cared at first to beleive. I think the issue is aswell with insulin resistance is that it can be hard to diagnose. Needing fasting insulin levels and not simply fasting sugars. And if this is out of whack it could cause a whole host of issues. I'm on a mission to clean up my metabolic chemistry at the moment.

That interesting. I've begun to wonder if finasteride and 5AR sexual side effects may possibly be related to insulin resistance, metabolic syndrome and endothelial dysfunction. Some evidence that dutasteride mesotherapy is less effective in insulin resistance also.

Thanks for sharing. Not discrediting your experience...but do you think there is a chance this may have been nocebo? After all, the mechanism this works by, causing reduction of the AR, should take a little time to come into play and equally take some time to rectify and rebuild levels of AR. If the symptoms came quickly and left quickly, it does make wonder if this MAY have been unrelated. The mind is a powerful thing after all.

Anyone with any updates on cosmerna?

It's a tricky one isn't it. I recently had some ED with alfatradiol too. I was reading into it. Turns out although 17alpha E2 is a weak estrogen in many tissues it can apparently act as a stronger estrogen in some other tissues...one being the brain. Which actually makes sense with me. Just have to find out what works for each of us i guess.

Ah OK. Thanks for clarification. Good you are working with a urologist I guess then. I'm glad cosme seems not to be giving you sides. The study from dermatest supposedly showed better results with twice weekly anyway so maybe no better than weekly. I think pairing it with an androgen receptor antagonist seems a good idea.

But no Erectile dysfunction on cosme?

Hi Arthur Sam. Can I ask do you apply cosmerna every week or every 2 weeks? Also...thanks for sharing your encouraging story. I too had awful sides from fin (both oral and topical) which has made me very nervous to even try topical dut. I figure I may give cosme a go...afew people stating its stopped their shedding. I'm shedding badly at the moment. So would be nice to have something to at least stabilise my loss. I presume still no side effects with cosme? Thanks

How you getting on with cosmerna?

I think I agree with you. As much as I agree with Melvin that any company faking before and after photos is not on (if that's what's happened here). That being said, It could be a disconnect... poor marketing decisions vs the science. Hopefully, the product at least may halt hairloss and prove an alternative to fin and dut. If it does this without sides, I'm taking that as a positive. As you say...we will know soon. Arthur Sam's testimonial is encouraging.

Anyone any further updates with their Cosmerna usage/results/sides?

I would appreciate any information you can get hold of.

I agree. I never had any postive results from taking oral saw palmetto. I'm actually had some old bottles of hairmetto that I hadn't really used much of. So I've decided to restart use and really monitor my shedding and see what happens. I have to credit Derek at MPMD with his video advising a hair catcher in the bath/shower. Given hairloss is a real long term game, where you may not see actual visible results for 6 to 24 months, having a tangible metric like how many hairs you shed, can be an invaluable took to guide you on if something may actually be working and you just need to stick with it. Who knows how many treatments I may have started in my past but never carried on beyond afew months because I didn't see any instant effect. To be honest, I now view just halting progression as a major victory. So maybe I gave up on topical saw palmetto way too prematurely last time. The good thing is when I used it for afew months I never had any noticible side effects. Certainly nothing like what finasteride did to me. Apparently many saw palmetto brands use inferior extraction methods. So I'm guessing not all products are equal. I'm still not sure what does the heavy lifting, ie beta- sitosterol vs certain fatty acids. Maybe a combo. But I guess it's those things which you want a lot of in any topical. I'm going to use the oil at night, then a non greasy saw palmetto in the mornings. Let's hope we can see some decent results. If it blocks even a bit of 5AR, it will mean that topical androgen receptor blocks have less work to do. Throw in a AR reducing drug/product like cosme or GT, and I think there may be a potential of a very potent stack.

Good to hear mustang. Keep us posted. Im considering cosmerna to be honest. Along with an androgen receptor blocker. I was reading that even gamma linoleic acid that blocks 5AR does so irreservably at least somewhat, which does make me a little concerned for finasteride-like side effects which may linger on afew weeks after disconinuation if they occur. Presume you've not noticed any side effects? Update... You've inspired me to hop back on topical saw palmetto mustang. I had such bad experiences with fin, that I just couldn't get over the fear and try topical dutasteride. I figure topical saw palmetto and pyrilutmide might work well instead. I have heard oral saw palmetto only has about 18% of it arrive at the skin and scalp. So maybe it is a whole different beast when used topically, especially with some microneedling once a week. Will keep you posted.

Cheers Dave. Great to be getting good quality feedback like this. Very thorough and helpful. And really good (to me at least) that this feedback is coming from someone who got fin side effects (I also did!). So hopefully if someone like you can tolerate cosme without issue, it gives a lot of us hope. Thanks for the updates and please do keep them coming. I agree the once every two week application sounds like a dream. At one point I was trying to apply topicals 3 to 4 times a day to maximise results. Twice daily is hard enough.

So the saw palmetto topical you are using is trichometto? Do you know if they ship to the UK? Is it standardised to a percentage or concentration of fatty acids? The hairmetto states 85 to 95% fatty acids. CO2 extraction which is apparently best method.

But CB0301 was tested at 7.5% BD...and I beleive showed good safety? I doubt a weaker strength would be effective for AA as its not a very strong anti androgen mg for mg (I beleive...relative to DHT at least). Probably need at least 150mg per day topically to stand a chance of fighting the good fight. Well...let us know how you get on with saw palmetto. I suppose if the concentration is high enough and from a decent quality product, you may be luckier than many who have failed with it. I'm sure microneedling can only help with absorption. I may even be tempted to give my hairmetto non oily another go 🙂 I'm hoping cosme will be a hit...that would be great news for us all 🙂🙂

So just after I mentioned I'd not heard about CB 03 01 for ages, follicle thought article announcing it'd FINALLY entered its phase 3 study. I thought it had been dumped...but I think it's way more to do with the company merging or something maybe. So...2025 it may be out. Also mustang...I realised I also had an old bottle of the hair metto non oily which also has saw palmetto..it contains 200mg per 5ml of CO2 extracted saw palmetto standardised to 85-95% fatty acids. What percentage would this make it? What specific ingrediant is your 20% standardised to? So your thoughts are saw palmetto is only really effective topically? I suppose if you could get a very high dose to the follicles and may even applied multiple times a day...it could maintain a higher level of the fatty acids needed to block 5AR. I believe it blocks both type 1 and 2? I guess the good thing with fatty acids being your 5 AR blocker is their half life is very short...both a pain as you need to apply very frequently (I bet 4 times a day would be better than 2 if possible...but totally unfeasible unless you never leave the house haha). But this same fact means even if it worked its way around the body and you got sides, I bet the side effects would not last long. Also regarding sides...I wonder if these fatty acids bind in a suicidal manner to 5AR? I beleive finasteride and dutasteride bind and never let go? So if you get sides you need to wait ~90 days to rebuild all your lost 5 AR (i think this accounts for a lot of longer lasting sides*). Whereas if the fatty acids dissociate after afew hours, if you got sides, waif afew hours and your back to normal. Hmm...need to try and do some research on this! *of of the docs on the hairloss show states he always felt the halflife for fin IN THE TISSUES was actually much longer than afew hours...more like weeks. Whether that lasting in the tissues is actually because it never let's go of the 5AR once bound (suicidal binding) and as the enzyme may last weeks, it is technically in the system for longer?! Finally...have you ever used alfatradiol? That ca supposedly act as a topical 5AR inhibitor.

I thought pyrilutamide was pretty safe when I read the studies?? No reports of much other than scalp irritation?? Where did you read it had bad sides? I think with cosme, it all depends how systemic it goes...like with topical dut. My personal opinion is almost all topicals must go systemic to some degree, its probably just a case of how much and what their half life is until they degrade into something else, and if that that something else has any inherent effects of its own. If there were bigger studies on cosme showing safety and blood serum levels of the compound after use (like they did with pyrilutamide) I'd feel a bit more comfortable. Overall I just wish they had more efficacious drugs which worked on non androgen pathways where there was just no risk if anti androgen side effects. I wish they had done more with topical ciclosporin. It showed quite a lot of promise in the small studies done. OK...so you may think this is whacky but have you ever read about botox use for androgenic alopecia? I've been experimenting with scalp massage recently, and weirdly I think I've seen a reduction in shedding. Seriously considering botox as when you read the small scale studies done, they had comparable results to finasteride!

I wish you the very best of luck 👍 🙂 let us know how you get on with it. Trichometto looks interesting. I agree CB 0301 seems safer. However it's seems to have stalled. Not heard anything about it for years. Pyrilutamide will be released first I think. Will be awesome when that's commercially available. GT20029 I think may be the best. I agree about cosme. I think I have resigned to wait for at least afew more months before trying it. The idea of something preventing ARs developing elsewhere in my body if it goes systemic, which I have seen no data to say why it theoretically can't, is off putting (for me at least).

Hi Mustang. Can I ask why you no longer take topical dutasteride? Apolgoes if you've already mentioned this somewhere already. I tried hairmetto...a topical saw palmetto. Granted I probably didn't give it long enough to work, but I didn't really see anything obvious for the couple of months I used it. Not sure I put enough on really either. Very greasy so it required twice daily hair washing which became difficult to maintain. Good video on YouTube documenting a guy who microneedled with hairmetto for several years and supposedly got fairly good results (as long as he was genunine and honest and not using fin and not telling us...I think he seemed genuine). What are you thoughts on cosmerna? And RU?