K?RATENE Alphactive ® Retard

[HARIRI]

KERATENE® alphactive Retard is a systemic 5-ard enzyme catalyze inhibitor, formulated specifically to suppress the formation of dihydrotestosterone (DHT) and delay the effects of this androgen on the genetically-marked hair follicles, sensitive to its chemical signals. KERATENE® alphactive Retard provides an appropriate control mechanism for the progressive thinning of hair caused by hormonal and genetic factors, with potential applications in the trichologic field for the for the maintenance of the existing hair density, in both pre- and postoperative cases.

KERATENE® alphactive Retard depresses the total DHT level by suppressing the conversion of the androgen Testosterone (T) to DHT through the adhesion to the 5aRD enzyme by obstructing the transfer of hydrogen atoms to the Testosterone (T) molecule and preventing its chemical reduction.

KERATENE® alphactive Retard reduces the DHT levels with a factor of 2, 3 or 4, depending on the total DHT level. KERATENE® alphactive Retard does not interfere with the endocrine production of hormones or with the production of the 5aRD enzyme and its inhibition mechanism does not rely on the use of antagonistic exogenic hormone disruptors or on the use of xenoestradiols or estrogens. Consult your doctor before using this product or any other medical anti-DHT treatments. Read the product description carefully before use. KERATENE® alphactive Retard is not a cure for any registered medical disease. Consult your doctor for professional medical advice.

 

KERATENE® alphactive Retard, in combination with topical K?RATENE® alphactive therapies, is suitable as sustaining therapy for the preservation of the trichological density for clinical cases of NW I, NW II, NW III (vertex only), Ludwig I and Ludwig II. This product is not effective in cases of alopecia totalis, alopecia universalis and alopecia androgenetica NW4, NW5 and NW6 as well as Ludwig 3 where total loss of hair density has already occured

 

 

- Lowers dht by 25%

- Is fin without side effects/same benefits

- Vouched by pro hair clinic

 

They provided solid scientific proof that Keratene Retard is able to reduce DHT blood values. If you are going to present your product that claims DHT lowering properties you better have good solid evidence if you are presenting in front of dermatologist and doctors.

Prohairclinic offered to perform a small additional test to backup the Keratene Retard clinical data.

We teamed up with the university of Gent to measure before and after DHT blood levels.

At half the prescribed dose of 1 capsule a day there was an average lowering of 25 % of DHT levels for male subjects.

There were no changes in DHT levels (slightly up) for female subjects.

 

Vegan-friendly : this version is not suitable for Vegan consumers. The gelatin capsules contain animal ingredients obtained according to Kosher / Halal standards

Therapeutical compatibility : not compatible with BPH products based on soy or saw palmetto, Finasteride, Dutasteride, Flutamide of Bicalutamide. Special precautions for users of any ACE (angiotensin-converting-enzyme) inhibitors: consult your doctor before using this product

Side effects : read the enclosed product specific instructions or the online product page. Not suitable during pregnancy or lactation

Sale regime : dietary supplement - OTC

Concentration grade : total DHT reduction factor 2 - 3 - 4

Composition : complex sterols under the DRD of 3gr/24h, plant extracts, saccharose

Active system : 5-ard enzyme catalyse inhibitor

Volume : 60 capsules

Price: EURO 42.95

Edited April 26, 2013 by HARIRI

[HARIRI]

Here are more information about it from Pro Hair Clinic which I believe endorses the product officially.

 

KERATENE® alphactive retard

 

Male hair loss is often due to the negative impact of high DHT (Dihydrotestosterone) levels which have a negative influence on the hair roots. This phenomenon is already known for a long time and is often validated by medical research. There exists already certain medication which can decrease the DHT values, however those medicines can lead in some cases to certain unwanted side effects.

 

ATTENTION: DO NOT COMBINE KERATENE® alphactive retard with any of the older DHT decreasing medicines!

 

KERATENE® alphactive retard is a NEW (2012) product which is developed with the latest knowledge and technology. Hence, this product has no side effects and is available without a prescription. KERATENE® alphactive retard is categorized as a “ nutritional supplement” this means that it can be freely sold in the EU. In addition, KERATENE® alphactive retard has all the necessary authorisations needed for sales in the EU.

 

KERATENE® alphactive retard got its first introduction during the FUE Europe meeting in Berlin 2012. The technical data as well as the results (blood value DHT levels before and after) were presented to all hair transplantation doctors who were present.

 

Technical information:

formulated specifically to aid in the delaying of the effects of the androgen hormone Dihydrotestosterone (DHT) on the

genetically-marked hair follicles. KERATENE® alphactive retard provides a better control of the progressive thinning of

hair caused by hormonal and genetic factors, and it is recommended for the maintenance of the existing hair density,

in both pre- and postoperative cases. KERATENE® alphactive retard is sold in some countries under the commercial

name of KE234® or Keratenosynergist®.

Use K?RATENE® alphactive retard as directed by your doctor or pharmacist.

 

COMPOSITION:

Sterol complex, phytoextracts, saccharose.

Contains trace amounts of campe- stigma- brassicasterol, triterpenoid esters, 3,4-divanillyltetrahydrofuran and

5-hydroxytryptamine. The formula is free of xenoestradiols and is suitable for both adult men and women.

KERATENE® alphactive retard is available in packaging of 30 or 60 gelatine capsules.

Substance regimen: dietary supplement

 

FUNCTION

 

KERATENE® alphactive retard depresses the total level of DHT by suppressing the conversion of the androgen Testosterone

(T) to DHT through the adhesion to the 5aRD enzyme by obstructing the transfer of hydrogen atoms to the Testosterone

(T) molecule and preventing its chemical reduction.

KERATENE® alphactive retard reduces the DHT levels with a factor of 2, 3 or 4, depending on the total DHT level.

KERATENE® alphactive retard does not interfere with the endocrine production of hormones or with the production of

the 5aRD enzyme.

The therapy with KERATENE® alphactive retard reaches optimal effects after 7 consecutive days of administration.

KERATENE® alphactive retard has low bioaccumulation and its effects dissipate after 3 to 7 consecutive days after the

interruption of the therapy. When the therapy is completely terminated, the DHT level will increase and reach its previous

nominal value, prior to the administration.

 

ADMINISTRATION

KERATENE® alphactive retard is administered orally.

 

Pre- and post-operative schedule, when the DHL level is known:

1) DHT level between 849 and 1673 pg/ml, 1 capsule per day,

in the morning between 8 and 9;

2) DHT level higher than 1673 pg/ml, 2 capsules per day, one capsule in the morning

between 8 and 9 and one capsule in the evening between 10 and 11.

Pre- and post-operative schedule, when the DHL level is not known:

Men older than 20 with NW 1 – 2: 1 capsule per day, in the morning between 8 and 9am.

Men older than 20 and younger than 35 with NW 3 – 4: 2 capsules per day, one capsule

in the morning between 8 and 9am and one capsule in the evening between 10 and 11pm.

Men older than 35 with NW 3 – 4: 2 capsules per day, one capsule

in the morning between 8 and 9am and one capsule in the evening between 10 and 11pm.

Women older than 25 with LUDWIG 1 – 3: 1 capsule per day, in the morning, between 8 and 9am.

Consult your dermatologist doctor or a specialist trichologist to establish the correct dosage for your specific situation.

 

SPECIAL PRECAUTIONS

KERATENE® alphactive retard is not suitable for pregnant women, during pregnancy or during the lactation period.

KERATENE® alphactive retard is not compatible with any other therapy based on synthetic 5aRD inhibitors or DHT

suppressors from the –steride group or with Flutamide / Bicalutamide. The combination of these therapies should be avoided

at all times. Because KERATENE® alphactive retard reduces the level of DHT androgen in the body, it may affect the

performance of professional athletes. It is recommended to interrupt the administration of KERATENE® alphactive retard

with at least 10 days before a competition. Consult your team physician or endocrinologist for professional medical advice

on the implications of low DHT and your athletic performance.

Edited January 24, 2013 by HARIRI

[HARIRI]

In my opinion, its not as strong and effective as propecia (Finastride) which lowers 90% DHT. However this product is very good for people like me who suffers sexual side effects from Finastride. I may order it next month when I finish my HAIROMEGA DHT which is basically a Saw Palmetto product plus other herbal ingredients.

 

Im so thrilled with this product. I wish from the bottom of my heart that it will slow my hair loss progression and will be a great weapon beside the Rogaine (Minoxidil 5%).

 

Here is the official site of this product K?RATENE® Official Web Shop ...

 

Good Luck everyone :-)

[johnnyk]

Hey Hariri,

great info, good job!

 

One mention though,

[- Lowers dht by 25%] is valid for people with slightly lower DHT.

In previous trials there were bigger differences, even up to 4 times less DHT.

People with stunningly high levels in the region of >1800pg/ml went after 10 days to 500 or lower. It's a good result.

 

[in my opinion, its not as strong and effective as propecia (Finastride) which lowers 90% DHT.]

 

From what the customer care says, I get this "... it lowers DHT dynamically and proportionally, accordingly to the total available level in the body..."

(in other words, if it's low, it won't reduce it too much, if it's high, it will work harder).

Overall it looks like a promising for the guys looking for an alternative to the current meds.

Have you tried it yet? Any personal impressions?

[orlhair1]

I have seen some press on this product recently. Anyone have any experience with it? Any doctors or reps have any thoughts?

[HARIRI]

Im going to order some when I get back fron my vacation. I will start taking it instead of my Hairomega DHT (Saw Palmetto ++). AIm glad that compensate Finastride intake. It not as strong as FIN but its better than nothing anyways.

[johnnyk]

I have seen some press on this product recently. Anyone have any experience with it? Any doctors or reps have any thoughts?

 

I'm on it since November last year.

Works out superbly, had DHT 1467 before, after 10 days dropped to 368.

Has some mild sides in the first week, but after that it went smoothly.

It's a new prod. will take a while to become known so I doubt any docs will rep it.

[HARIRI]

JohnnyK. Glad to hear that. Were you a Finasteride user before like me and suffered sides from it?

 

How about Keratine alpha retard? Any sexual sides like loss of libido or partial ED???

[aim4hair]

i hope it works as advertised.

one thing im sure of is that pro clinic is considered a reputable and having this product vouched by them and some other doctors is relieving.

 

but i don't beleive that it has no sides at all, it still plays with your hormones, right ?

[johnnyk]

JohnnyK. Glad to hear that. Were you a Finasteride user before like me and suffered sides from it?

 

How about Keratine alpha retard? Any sexual sides like loss of libido or partial ED???

 

Keratine?

No, I'm not on Keratine, I'm on Keratene, it's a bit different (French spelling, sounds like Kerrrataenae, very french, all open ae's like in Kenya). Keratine is something else.

 

I tried fina for 6 months prior, on and off, ending in a total halt after 6 months.

I know it works fine for other men, but I'm not included in that crowd.

Form K?ratene I had zero libido loss no erectile dysfunction, nada. It went ok, from the start till now. I'm pleased so far, like i said.

[johnnyk]

i hope it works as advertised.

one thing im sure of is that pro clinic is considered a reputable and having this product vouched by them and some other doctors is relieving.

 

but i don't beleive that it has no sides at all, it still plays with your hormones, right ?

 

Well, there is a way you could find out... test your DHT. That will tell you right away, after 8 or so days.

I mean, you should see some change in the level of the hormone.

 

According to the producer, it does not work on the hormone(s) as in inhibiting their secretion. All it does is prevent the chemical reduction of Testosterone into DHT. It does not inhibit the enzyme production and it does not influence other hormones in the body. It is an indirect DHT depressor.

It basically leaves everything untouched, and it simply prevents one simple reaction between two substances from happening.

Uncomplicated yet elegant.

To back up the claims, the tests I've done measured several parameters, level of total t, free t , lutropin, sbhg, dhea, estradiol, estrogen and dht. All except the last, all were pretty much (+/- 6%) the same, whereas dht had a large variation, 350%. Too large to ignore or label it as incidental. And this was reproduced twice. I'll do one more test this year. Keep you posted.

[johnnyk]

My reference goes to this keratene version

Perhaps guys sensitive to Finasteride wanna look into the above too, could be interesting.

[Spanker]

In my opinion, its not as strong and effective as propecia (Finastride) which lowers 90% DHT. However this product is very good for people like me who suffers sexual side effects from Finastride. I may order it next month when I finish my HAIROMEGA DHT which is basically a Saw Palmetto product plus other herbal ingredients.

 

Im so thrilled with this product. I wish from the bottom of my heart that it will slow my hair loss progression and will be a great weapon beside the Rogaine (Minoxidil 5%).

 

Here is the official site of this product K?RATENE® Official Web Shop ...

 

Good Luck everyone :-)

 

 

I thought I read that fin reduces DHT 70 percent??

 

 

Well, there is a way you could find out... test your DHT. That will tell you right away, after 8 or so days.

I mean, you should see some change in the level of the hormone.

 

According to the producer, it does not work on the hormone(s) as in inhibiting their secretion. All it does is prevent the chemical reduction of Testosterone into DHT. It does not inhibit the enzyme production and it does not influence other hormones in the body. It is an indirect DHT depressor.

It basically leaves everything untouched, and it simply prevents one simple reaction between two substances from happening.

Uncomplicated yet elegant.

To back up the claims, the tests I've done measured several parameters, level of total t, free t , lutropin, sbhg, dhea, estradiol, estrogen and dht. All except the last, all were pretty much (+/- 6%) the same, whereas dht had a large variation, 350%. Too large to ignore or label it as incidental. And this was reproduced twice. I'll do one more test this year. Keep you posted.

 

What do you mean a variation of 350 percent? If it was reduced, 100 percent is as low as it can go, so did it go up? Or did it go up and down?

[johnnyk]

I mean the difference, the ratio between the initial value 1467 and end result 368.

The math behind the number is according to the equation:

 

(Given amount Divided by Total amount) x100 = %

Or you can calculate it by multiplying the number you have, by the percentage you are after, so, if you want to know 29% of 352, you would do 352 x 0.29 = 102.08

 

respectively, in my case:

 

368 (end value) x 4.1 (as in 401%) = 1476 (initial value)

ergo, 401%

 

My mistake was that I said 350% where it should have been 401%.

 

Yes, it went up when I stopped and my wallet went down with another 200 bucks to repeat the test.

And it went low again when I started again. So did the wallet.

 

----------

Nope, Fina can drop DHT from 2470 (huge btw, but 'achievable') to under 190 (confirmed TC-LMS!).

That is not 70%, that it's a whopping 1300% and... pure endocrine mess-up (good to know for the casual consumers).

 

In math , that is

190 x 13 (as in 1300%) = 2463

Edited February 7, 2013 by johnnyk

[HARIRI]

I contacted the person in charge of the company Mr. Marc Costin from Holland and he actually answered all of my questions with full confidence and asked his employee to send me further details. Here are some:-

 

What is Keratene?

Keratene is a a French brand invented in 1947 by a French pioneer in the cosmetic industry.

The brand was taken over by its current owner, Hairclinics Netherlands, in 2010.

The pronunciation is as such, purely French and sounds more like Ke – as in Kenya, Ra- as in Ramon, Ten – as in the number 10, and not like Keratin.

It is important that the public retains the correct spelling so that no confusion arises.

 

What no one heard about it?

The brand itself is rather unknown due to the fact that it is an European native product, with little exports.

Since its re-introduction in 2010, it become slightly more known.

It will take some time until the product will become more known. Given that fact that in Europe and other countries advertising of any form of medical products or dietary supplements with claims that are not approved in the directive 26, is strictly forbidden, it will takes a few years.

 

What is Keratine alphactive Retarde?

The product you talked about, respectively Keratene alphactive Retarde is very new, just launched last year, in Berlin, at the annual meeting of the FUE Europe society.

Keratene alphactive Retarde is a systemic 5ard enzyme catalyse inhibitor and an indirect DHT depressor (not suppressor).

 

How does it work?

The molecules works not by inhibiting the production of 5ard enzyme or by regulation the secretion of hormones, but rather by attaching itself by electro-chemical valence to the 5ard enzyme and acting as an insulating factor.

As such, the transfer of atoms of hydrogen to the testosterone molecule happens in a lower ratio.

This leads in turn to an overall reduction of DHT.

As such, the 5ard enzyme production and the testosterone hormone are left untouched.

The only thing which happens in a lesser amount, is the transformation of T into DHT.

 

How much will reduce the DHT level?

The product work on the “work on what you have” principle.

In other words, it lowers DHT dynamically, adaptable, according to the total amount of DHT available in the body. Men with very high DHT levels can expect a large reduction, with a factor of 2, 3 or 4, whereas men with little DHT, can expect a reduction with just 35 to 70%.

 

Does it contains the usual Saw palmetto extracts?

No, Keratene alphactive Retarde does not include Saw Palmetto or any forms of commonly used plants for prostate supplements.

It is a proprietary mix of various organic substances and enzyme catalyst aggregators, not synthetically engineered.

 

Are there differences between KaR and finasteride?

Yes. Keratene alphactive Retarde is completely different than finasteride.

Finasteride is a synthetically engineered molecule, with specific chemical properties.

Keratene alphactive Retarde is an organic compound, not synthetically engineered.

Finasteride has the chemical potential to penetrate the blood brain barrier (see latest FDA updates on fda.gov) and has the bio-chemical potential to influence the pineal gland, the processes that coordinate the production of lutropin, the correlation of the sex-binding hormone globulin, dhea, and many other related factors.

In addition, it may increase on the long run the risk on malign prostate neoplasm with roughly 1.6%.

Because the body perceives its molecule as a foreign chemical, the metabolic processes employed by the body to follows the same pathways as any other medication (see cytokine reduction), whereas in regard to KaR, the body process the substance as an organic element.

 

Is it safe?

The product is safer than any other alternative available on the market today.

It does not interfere with the endocrine production of hormones, of hormone precursors, of enzymes or related peptides. It also does not influence the shbg or lutropin, fact that defines its “libido-friendly” characteristic.

In other words... enjoy the goods without the damage.

Up to date, no user reported any sort of erectile dysfunction or libido problems.

 

Are there side effects?

KaR may present several direct side-effects and several indirect side-effects.

They are indirect due to the fact that they are not cause by the product itself but rather by the effect of having a lower DHT level than the body is used to.

One direct side-effects is known from the use of the topical products and that is transient paresthesia (tingling of the skin). This effects is normal, known for several years and can last up to 7 hours after administration and was reported by less than 1% of the tested population.

Another potential side-effect is mild seborrhea, especially on the topical products.

 

Indirect side-effects, not caused by the product itself but by the reduced levels of DHT on the body are:

fatigue, reduced athletic performance, transient reversible mild cognitive impairment (TRMCI - popular "brain fog/haze"), mild head-aches, nausea.

Such effects generally dissipate after two or three weeks of administration, once the body accommodates to the new, reduced DHT levels.

Such effects are reported in less than 1% of the tested population and may have other, idiopathic causes or contributing factors as well, such as lack of proper nutrition, stress, prior underlying conditions, etc.

 

 

Is it a medical product or not?

The product is not a registered medicine in the traditional sense, like ibuprofen is for instance.

the costs associated with such registration in todays’ terms are completely prohibitive.

This is one of the major reasons that nowadays in Europe there are no small of middle-sized private pharmaceutical companies that bring innovative products on the market.

The average costs only for the safety assessment, clinical trials and registration procedure for each new product are estimated at minimum 6 million euro ( ~8 mill USD) for a period or 6 years, and this amount excludes the research and development needed prior to its public testing and application for registration.

Depending on the legislation of each country, the product is sold as dietary supplement or, in specific countries, as registered phytomedical (registered medical product based on plant extracts).

In Europe it is labeled under the applicable legislation for dietary supplements.

As such, under the current legislation, we, like many other small innovative companies, are forced to operate under the law that regulates foods, rather than medical products.

We are aware that the titling may not be very appealing or trust-inspiring for the consumer (herbs! dietary supplements!), but we must comply with the legal requirements.

 

To conclude, here are a few of the main key benefits:

1 fast catalyse inhibition with low bioaccumulation, free of 17-beta-estradiol disruptors

2 evident DHT reduction up to 4 times, comparable to synthetic -steride alternatives

3 ssbg/lutropin/fsh bio-chemically neutral formula, virtually no impact on libido

[orlhair1]

Hariri, thanks for following up on this. It really is of interest given the issues associated with Fin. I am able to take Fin without sides, but I still worry about the safety of the drug. It will be interesting to continue to follow this and see what develops. I wonder if it is sold in the U.S.?

[HARIRI]

orlhair1, I ordered 3 months supply already and willing to start taking it along with Rogaine (Minoxidil 5%). Just waiting for the product to reach. I'm 100% confident of the safety of this product. I will take it instead of the Saw Pametto Beta Sitosterol herbal supplement (Hairomega DHT).

 

Again, I wont expect the efficacy of Keratene Alphactive Retarde as the Finasteride but I'm sure it will do at least 50% of the job. Its better than nothing in my opinion as I really cant tolerate the Finasteride sexual sides on me. This coming product will control my DHT and will work well with Rogaine as a team :-)

[orlhair1]

Good luck with it and keep us posted. A lot of people get great results taking Fin at half doses (every other day, etc), so no reason that this will not help significantly for you.

[HARIRI]

New study confirms DHT lowering properties of Keratene Retard - Alternative for Finasteride

 

 

Prohairclinic has set up a small study in corporation with the University of Gent in order to obtain more information about the effectiveness of DHT lowering properties of Keratene Retard. The University of Gent is the only facility in Belgium that can measure DHT levels accurately (using LC-MSMS).

 

This was a limited test, only testosterone and DHT levels where measured. Of the 13 test subjects 10 finished the study.

 

There were 3 woman in the test, 2 of them suffering from hair loss. DHT lowering was not achieved by any of the female test candidates, a slight increase was measured at 2 of the 3 woman. Probably one can conclude that the cause of hair loss in 2 of the 3 woman was not related with increased DHT levels, but this was expected.

 

The man subjects took 1 Keratene Retard tablet per day, this is half the dose which is usually taken.

 

An average reduction of 25% of DHT levels where measured after taking Keratene Retard for 1 week. Testosterone levels remained unchanged.

 

MAX = 57%

 

MIN= 5%

 

Important : There where no reports of any side effects, not even libido problems. The woman did not report any side effects either.

 

Most men with elevated DHT levels will profit from Keratene Retard to surpress DHT levels and reduce or stop progressive hair loss caused by male pattern baldness (MPB). There will be some persons that will not benefit from this product, but this is no different to the other known DHT suppressors.

 

Keratene Retard, like Finasteride or Dutasteride, is meant for a long term treatment of MPB. The treatment is a good solution until one day there will be a final and definite solution to hair loss.

 

As far as we know Prohairclinic is the only clinic that has tested the products it offers by performing professional clinical trial. Trust is good, verification is better.

[Stublue]

Hi Hariri,

 

Would be very interested to know how you get on with Keratene Alpha Retard. I too was on finasteride but stopped about 5 months ago due to libido issues. I have talked to a rep from prohairclinic and he highly recommends the product (I suppose thats to be expected!!).

 

I am actually due to have around 2,000 FUE with Dr. Bisanga in 2 days time so I will make sure to ask him what he thinks of it and will update the forum.

 

Would be great to have an alternative to finasteride as I am concerned that I am having a HT without the meds (although I am still using minoxidil).

[socates123]

How about Nizoral?

[fitnessjunkie]

Hi folks,

 

Does anyone else have any experience with Keratene Retard? I'm looking to combine this with 5% minoxidil.

 

I've been on and off Fin for a number of years but have had issues with depression and gyno... wouldn't surprise me if Fin was the culprit!

[HARIRI]

Yes I do. Im taking one capsule a day before bedtime and apply 5% minoxidil once a day. Keratene works similar with Fin which is stopping further hair loss while Minoxidil is important to increase blood supply to the follicles to regrowth them. Im using Keratene for a month and a half and my hair loss reduced a lot and my libido is back to normal. The only side i experienced is partial fatigue. However its recommended dose is two capsules a day.

[fitnessjunkie]

Yes I do. Im taking one capsule a day before bedtime and apply 5% minoxidil once a day. Keratene works similar with Fin which is stopping further hair loss while Minoxidil is important to increase blood supply to the follicles to regrowth them. Im using Keratene for a month and a half and my hair loss reduced a lot and my libido is back to normal. The only side i experienced is partial fatigue. However its recommended dose is two capsules a day.

 

Hi Hariri

 

I've been following your progress on another site

 

I'n contemplating a 3 month supply but obviously there does not seem to be heaps of info out there as the product is so new.

 

Has anyone on the Keratene Retard got their DHT's level checked?

[Bobilero]

Hi Hairi - Hows your progress coming along? Any sides at all so far?