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I do not take saw palmetto nor do i think it has a positive effect on hair loss. A recent study suggests other wise, see what you think The standardized extract of Saw Palmetto, (Permixon), has been extensively used for the prevention and treatment of hair loss since it first widely appeared on the European market some 17 years ago. Its reported efficacy has gotten mixed reviews. Many have claimed to have gotten moderate to significant results, while others maintain it is completely useless. There is only one study in the medical literature evaluating its effects on hairloss, and this study showed a positive result over a 6 month period. What is problematic about this study though is that one (not all) of the authors noted has a commercial interest in an oral, Saw Palmetto based, hair loss treatment product. This in itself may not necessarily negate the results. Another study, sponsored by Merck, the manufacturer of both Proscar and Propecia, evaluated the ability of Saw Palmetto to improve BPH (prostate enlargement) symptoms and lower serum levels of DHT (dihydrotestosterone) compared to finasteride(Proscar/Propecia). Not surprisingly, Saw Palmetto came out the big loser, as it showed no effect whatsoever on BPH symptoms and no effect on serum DHT levels, while finasteride dropped DHT by 65%. This one study by Merck was unfortunately enough to cause many to abandon its usage. Despite this negative result in a company sponsored study, subsequent studies showed Saw Palmetto to be at least as effective, and often superior to finasteride in its ability to mitigate the symptoms of BPH. So what gives?? The significant part of the answer lies in one of its identified mechanisms of action. There is a common and erroneous perception that Saw Palmetto and Propecia work the same way. Saw Palmetto, unlike finasteride (Proscar/Propecia), does not function as a 5 alpha reductase inhibitor that results in lower serum DHT (at least according to Merck). It works instead by reducing the uptake of DHT at the receptor sites by a factor of 40%. Another erroneous perception is that Saw Palmetto somehow only inhibits androgen binding in Prostatic tissue, and somehow leaves other sites in the body unaffected. The following study shows a reduction of DHT in all tissue specimens evaluated. Acta Obstet Gynecol Scand. 1988;67(5):397-9. The effect of Permixon on androgen receptors. el-Sheikh MM, Dakkak MR, Saddique A. Department of Obstetrics and Gynaecology, King Khalid University Hospital, Riyadh, Saudi Arabia. Permixon, the liposterolic extract of the plant Serenoa Repens is a recently introduced drug for the treatment of benign prostatic hyperplasia. The effect of Permixon on dihydrotestosterone and testosterone binding by eleven different tissue specimens was tested. The drug reduced the mean uptake of both hormones by 40.9% and 41.9% respectively in all tissue specimens. Since hirsutism and virilism are among other gynecological problems caused either by excessive androgen stimulation or excess endorgan response, we suggest that Permixon could be a useful treatment in such conditions and recommend further investigations of the possible therapeutic values of the drug in gynecological practice. These findings would seem consistent with the many anecdotal claims made by female bodybuilders that Saw Palmetto reliably prevents the hair thinning and body hair growth (hirsutism) often induced by certain anabolic steroids. So what does all this mean for hair loss treatment?? It would appear to indicate that Saw Palmetto is likely very useful as a hair loss intervention, however its ascertainable effects on hair, like any mild anti-androgen, take a long time (often 1 year or more) to manifest. Not unlike Proscar , when it first came to market in '92, many have tried Saw Palmetto for a few months, didn't see visible results, and concluded it "didn't work". When Proscar(5X more finasteride than Propecia) was being experimented in the early years, prior to its FDA approval for hair loss, the consensus was that it useless, and a big disappointment. The reason for this was that the results for most were subtle and virtually undetectable for the first 6-9 months anyway. As we all know, Proscar (5mg finasteride) went on to become FDA approved for hair loss at a 1mg dose,(Propecia) in '98, a full 6 years after it came out. I was personally fortunate enough(at least for my hair) to have stayed on both Saw Palmetto and a ?? tablet of Proscar since '92. In 2004 I dropped Proscar for prophylactic health reasons (having to do with elevated estrogen levels) and have since been on a Saw Palmetto/Pygeum/Nettle /Cernitin/Beta Sitosterol combo (amongst a plethora of other compounds) with no apparent detriment to my hair. The fact is that anti-androgens by themselves are slow acting and very gradually produce subtle at best cosmetic results, and are generally far more useful for hairloss prevention and attenuation than they are for regrowth. As such, Saw Palmetto, if continually used, will likely give results equivocal to Propecia, and due to its unique mechanisms of action, can be combined with Propecia and other treatments for an additive effect.

There is much speculation about the future of hair loss, Some say 2 years others say 20. I am not saying eather one but it does turn out that there are more things being worked on than i originally thought. Take a look and feel free to research them Max Planck Institute (Germany) - A topical gene therapy. Anticipated availability, 2007. Glaxo Wellcom - A 5-alpha reductase type I and II inhibitor. Dyad Pharmaceuticals - Developed from "antisense" technology. A topical 5-alpha reductase inhibitor. Genta Inc. - A proprietary antisense "nucleotide" that blocks the androgen receptor. Anti-Cancer Inc. - La Jolla, Ca. A topical treatment based on the deactivation of the baldness gene. Designed for daily use. Roussell Uclaf - A topical antiandrogen. RU58841, developed by Dr. Sewaya. Currently on hold, its commercialization is expected to be pursued in the near future. Dr. Holick - University of Mass. Developing parathyroid blocking compounds in order to turn cell division back on, and thus stimulate hair growth. Zeneca Pharmaceuticals - Estrogen blocking compounds that have shown promise in animal models.

There is much speculation about the future of hair loss, Some say 2 years others say 20. I am not saying eather one but it does turn out that there are more things being worked on than i originally thought. Take a look and feel free to research them Max Planck Institute (Germany) - A topical gene therapy. Anticipated availability, 2007. Glaxo Wellcom - A 5-alpha reductase type I and II inhibitor. Dyad Pharmaceuticals - Developed from "antisense" technology. A topical 5-alpha reductase inhibitor. Genta Inc. - A proprietary antisense "nucleotide" that blocks the androgen receptor. Anti-Cancer Inc. - La Jolla, Ca. A topical treatment based on the deactivation of the baldness gene. Designed for daily use. Roussell Uclaf - A topical antiandrogen. RU58841, developed by Dr. Sewaya. Currently on hold, its commercialization is expected to be pursued in the near future. Dr. Holick - University of Mass. Developing parathyroid blocking compounds in order to turn cell division back on, and thus stimulate hair growth. Zeneca Pharmaceuticals - Estrogen blocking compounds that have shown promise in animal models.

Rem do you notice any receeding in the front?

It is possible that the combination of propecaia and rogaine can stop hair loss. However it is much more common for the two to significantly slow down the hair loss process. I am not very familiar with dr.Rajput but i can say that multivitamin tablets will probably not do anything for your hair.

Sanjeeve, propecia is a real hot topic in all hair loss communities. Propecia blocks 70% of DHT(what makes hair fall out) therefore signifficantly slowing down the hair loss process. When tested, 2% of men expirenced sexual side-effect, altough many debate that it is more common that just than 2%. The people that I know personally who take it have not experienced eide-effects. If you expirence theses side-effect and stop there is a more than likely chance that you will return back to your normal self. As far a being chained to propecia the anwser is yes and no. It is true that if you stop using the drug you will lose the hair you had maintined. On the other hand during use, an alternative may prop up that allows you to stop using propecia. Transplanted hair is not effected by propecia becasue the hair on the back of your scalp is stronger than that of the top. Propecia does help the front of the scalp although it is probably alittle more effective in the crown area. It certainly helps both areas though. I have never head of fabao 101 but im highly doubtful it will have any effect on your hair.

Vargamn your statement is actually untrue. It works for the whole scalp including the hairline. Hair loss drugs are usually only tested on the crown and therefore only say that they work on the crown. I assure you 23newjersey that propecia will affect the areas of your scalp equally.

i disagree. Many people have question and having alot of people i a chat room can drown alot of the questions

Im going to disagree with you on this point. Propecia effects the scalp equally. It blocks DHT so it cant reach the scalp. It doesnt just block to the crown region. JonJon, This is a tough one. You are correct that although it can sometimes reduce prostate cancer it can also give you the worst kind. Saw palmetto nor all the rest of the alternatives you listed will give you any results. Id suggest at the very least to start taking rogaine 5% and nizoral shampoo as both can be an effective way to slow down hair loss. Consulting you doctor is a good idea, and whenever decision you do make sure your 100% comited to it.

I agree i think it should be scond nature to check into the chatroom when you enter the forum.

The laser technique is real debatable. The was a debate about it on this site that included over 100 posts, id suggest you read it if you can find it. I am not using a laser but in my personal optional and research its probably beneficial if your also taking Rogaine and propecia, but I wouldn't count on it if its your only defense against hair loss.

To be honest I don't know a whole lot about hairlosstalk as far as ordering from them. In my opinion it would be smarter to get a prescription from a doctor because you dont always know about the safety and the reliability of products purchased online

The script on the website that herbalhair posted is one of the most absurd things iv ever read

remember just because a product is natural does not mean that it doesnt have side- effects.Provillus active ingrediant, saw palmetto does not block DHT it just lowers it, which in turn causes a rise in estrogen. This will not cease MPB

Propecia works almost instantly

unidel are you currently on any hair loss medication?

morlock, I feel you on this one my man. Iv had a receding hairline since jr.year of height school. I also have my hair short (I shave it with a one guard). Its tough luck for us have our genes take effect so young but as you know things can be done. It sounds like you have typical Male pattern baldness but if your worried feel free to post some pictures. Also id suggest seeing a demonologist who specializes in hair loss instead of your doctor who probably will not know quite as much. As far as cost for propecia, proscar is much cheaper than propecia and just as effective. You simply cut the pill into the correct dosage. 1.The initial Shedding of hair us important when using Rogaine because it proves that it's working. Rogaine's job is to rid yourself of thin hairs and regrow them thicker and stronger. The shedding is usually not noticeable. 2. Many people do complain about sexual side effects in propecia but clinical testing has reported it in only about 2% of men. If you can afford it id highly suggest you get on it. I hope iv beed helpful and feel free to ask anymore questions.

Funny its the same thing with me I wish i could have a zero guard with a straight across hair line

this may be what youve heard of Wouldn't it be convenient to only have to get a shot once a month and not have to remember to take Propecia every day? That's a possibility in the future according to this recent study. It appears researchers in China are testing whether it's possible to create a time-release form of finasteride, the active ingredient in Propecia. The idea behind time-release medication is that it's encapsulated in such a way that the drug releases into the body in a controlled fashion over an extended period of time, thereby eliminating the need to take a tablet every day. In this test the finasteride was encapsulated in a propylene carbonate maleate plastic. When placed into a lab testing solution, the drug was found to release continuously for a period of 5-6 weeks. This is just an early test, but since there are already time-release drugs for birth control, it's quite possible that in the future this type of drug delivery method will be available to users of Propecia.

A comercial from sierra mist... http://news.hairlosshelp.com/category/balding-videos/page/4/

A comercial from sierra mist... http://news.hairlosshelp.com/category/balding-videos/page/4/

this artical was written awhile ago. My regular dermatoloigist Vera Price was quoted in this artical and I plan to ask her a few question about it. Does any one know more about this product because i havent heard it mentioned too much BOSTON--(PR NEWSWIRE)"??? Technology licensed by Follica Inc. from the University of Pennsylvania School of Medicine has been used to generate completely new hair follicles for the first time in normal adult mammals. The paper describing the experiment was published in the May 17th issue of the scientific journal Nature. By studying wound healing on a molecular level, Dr. George Cotsarelis and colleagues discovered that the skin has the ability to revert to a more primitive or "embryonic" state as stem cells migrate to the affected area, thereby achieving a regenerative capacity not previously appreciated to occur in adults. The researchers were able to control the regenerative response, including the extent of new hair follicle formation, by manipulating genetic pathways during this "embryonic window" when new follicles formed. The new hair follicles functioned normally, cycled through the normal stages of hair growth and exhibited normal architecture, including a full complement of stem cells. Cotsarelis and colleagues showed that the induction of this primitive state triggered corresponding embryonic molecular pathways distinct from those active in corresponding cells in adult skin, opening up new treatment options not previously thought to have therapeutic benefit in normal adult skin. "The "embryonic window" gives us the opportunity to develop disease treatments that act in entirely novel ways," said Daphne Zohar, PureTech Ventures founding managing partner and Follica CEO. "The clinical translation of this technique involves straightforward, safe dermatological procedures, and we are studying the impact of multiple drugs and drug-like compounds on this regenerative response as we advance in preclinical testing." "This is an extremely exciting discovery and shows promise for treatment of follicular disorders such as hair loss and unwanted excess hair," noted Dr. Vera Price, co-founder of the National Alopecia Areata Foundation, director of the University of California, San Francisco (UCSF) Hair Research Center and a founding scientific advisory board member of Follica Inc. "The hair follicle is an elegant structure that plays many different roles for human skin, aside from growing hair," said Dr. Rox Anderson, Professor of Dermatology at Harvard Medical School, Director of the Wellman Center for Photomedicine at Massachusetts General Hospital, and founding chairman of Follica's scientific advisory board. "George Cotsarelis' insights into the biology of hair follicles provide new strategies for preventing and treating a variety of skin and hair disorders." Follica exclusively licensed the technology from The University of Pennsylvania School of Medicine where it is the basis of an ongoing development program. The paper's lead author, Dr. Cotsarelis, is also a co-founder and scientific advisory board member of Follica About Follica Follica Inc., a privately held medical device company, was co-founded by PureTech Ventures and a group of world renowned experts in hair follicle biology and medicine. In addition to hair loss, Follica has intellectual property and development programs in various skin and follicle related indications. Additional Follica contributors include Dr. Kurt Stenn (Aderans Research, formerly of J & J, Yale) member of Follica's scientific advisory board; Dr. Ron Cape (PureTech partner, founder Cetus, former board member Neutrogena) Follica board member; and Dr. Steve Prouty (former J&J skin biology) Follica director of research. www.follicabio.com About PureTech Ventures PureTech Ventures is a Boston-based venture firm specializing in translating breakthrough research from top tier academic institutions into therapies that will impact human health and quality of life. PureTech 's partners include entrepreneurs and leaders from the top echelon of pharma, biotech, medtech and academia. www.puretechventures.com

this artical was written awhile ago. My regular dermatoloigist Vera Price was quoted in this artical and I plan to ask her a few question about it. Does any one know more about this product because i havent heard it mentioned too much BOSTON--(PR NEWSWIRE)"??? Technology licensed by Follica Inc. from the University of Pennsylvania School of Medicine has been used to generate completely new hair follicles for the first time in normal adult mammals. The paper describing the experiment was published in the May 17th issue of the scientific journal Nature. By studying wound healing on a molecular level, Dr. George Cotsarelis and colleagues discovered that the skin has the ability to revert to a more primitive or "embryonic" state as stem cells migrate to the affected area, thereby achieving a regenerative capacity not previously appreciated to occur in adults. The researchers were able to control the regenerative response, including the extent of new hair follicle formation, by manipulating genetic pathways during this "embryonic window" when new follicles formed. The new hair follicles functioned normally, cycled through the normal stages of hair growth and exhibited normal architecture, including a full complement of stem cells. Cotsarelis and colleagues showed that the induction of this primitive state triggered corresponding embryonic molecular pathways distinct from those active in corresponding cells in adult skin, opening up new treatment options not previously thought to have therapeutic benefit in normal adult skin. "The "embryonic window" gives us the opportunity to develop disease treatments that act in entirely novel ways," said Daphne Zohar, PureTech Ventures founding managing partner and Follica CEO. "The clinical translation of this technique involves straightforward, safe dermatological procedures, and we are studying the impact of multiple drugs and drug-like compounds on this regenerative response as we advance in preclinical testing." "This is an extremely exciting discovery and shows promise for treatment of follicular disorders such as hair loss and unwanted excess hair," noted Dr. Vera Price, co-founder of the National Alopecia Areata Foundation, director of the University of California, San Francisco (UCSF) Hair Research Center and a founding scientific advisory board member of Follica Inc. "The hair follicle is an elegant structure that plays many different roles for human skin, aside from growing hair," said Dr. Rox Anderson, Professor of Dermatology at Harvard Medical School, Director of the Wellman Center for Photomedicine at Massachusetts General Hospital, and founding chairman of Follica's scientific advisory board. "George Cotsarelis' insights into the biology of hair follicles provide new strategies for preventing and treating a variety of skin and hair disorders." Follica exclusively licensed the technology from The University of Pennsylvania School of Medicine where it is the basis of an ongoing development program. The paper's lead author, Dr. Cotsarelis, is also a co-founder and scientific advisory board member of Follica About Follica Follica Inc., a privately held medical device company, was co-founded by PureTech Ventures and a group of world renowned experts in hair follicle biology and medicine. In addition to hair loss, Follica has intellectual property and development programs in various skin and follicle related indications. Additional Follica contributors include Dr. Kurt Stenn (Aderans Research, formerly of J & J, Yale) member of Follica's scientific advisory board; Dr. Ron Cape (PureTech partner, founder Cetus, former board member Neutrogena) Follica board member; and Dr. Steve Prouty (former J&J skin biology) Follica director of research. www.follicabio.com About PureTech Ventures PureTech Ventures is a Boston-based venture firm specializing in translating breakthrough research from top tier academic institutions into therapies that will impact human health and quality of life. PureTech 's partners include entrepreneurs and leaders from the top echelon of pharma, biotech, medtech and academia. www.puretechventures.com

shedding is very common in propecia. The long run will provide the most information whether the product works or not. In the case of propecia you can hope to maintain your hairs.

shen min is a huge scam. ITs active ingrediant saw palmetto lowers dht but does not block it. Doing this does absolutly nothing for your hair loss.