quick explanation to what HMI-115 PRLR antibody treatment is:
„HMI-115 is a monoclonal antibody for the PRLR(prolactin receptor). It was licensed by Bayer to Hopemed Inc. It is currently in clinical trials for endometriosis and androgenetic alopecia. In early 2022 the company received FDA approval to conduct a phase II trial in the US for Androgenetic Alopecia, and soon after they received approval to begin a 6 month phase I trial in Australia that should demonstrate efficacy. The Australian trial is currently recruiting. The company has said that they hope to have it on the market by 2024, but that will be a difficult target to meet. They originally planned to move straight into a phase II trial for Androgenetic Alopecia since they had already completed a phase I for endometriosis. The FDA approved that, but Australia did not. The phase II trial now appears to be on hold until the Phase I in Australia is completed. They are currently conducting a phase II in endometriosis.Most of the information we have about the treatment comes from this patent. The patent details a trial conducted in stumptailed macaques. This is the best available model for human male pattern baldness. Stumptailed macaques have androgenetic alopecia like humans. They go bald when they hit puberty, and finasteride prevents this. All treatments that have been tested on both humans and macaques have similar efficacy in both, so that's a very good sign that this drug will work in humans too. What makes this treatment so promising is the amount of hair that the macaques regrew in this trial, and the quality of that hair. No other treatment has come close to growing this much hair in stumptailed macaques. Not even the combination of finasteride and minoxidil could come close. Additionally, the results last longer than other treatments. The macaques were injected subcutaneously with the antibody once every two weeks for 28 weeks, after which they had nearly full regrowth. Even after 4 years without treatment the macaques were still well above baseline. Other trials measure hair weight or the number of vellus hairs regrown. These measurements on the graphs below represent "thick terminal hairs", and you can see by the trichoscope image that miniaturized hairs returned to full thickness. Additionally, results did not plateau during the treatment period, so if treatment were continued for longer than 6 months they very likely would have had even more regrowth.“
from „pegasus2“ from a competetive forum
my question is: if the medication leads to full rewgroth what would happen to the transplanted hairs? would there be inflammation etc?