Der3k7

I hope so

4 months 

brushing hair back now instead of pushing forward 

Yeah I have and I am switching to duasteride with the next bottle.

cumulatively I have probably done about 21 applications of xyon so just getting started 

Side by side of me before surgery and now at 3.83 months 

On 3/16/2020 at 2:23 AM, Kraistoff said:

So everyone .

clinic has been in contact and I am debating whether to return to sort the density behind hairline out. 
 

i was given a reason for the poor result by the surgeon which did kind of help me think I’ll be ok second time around . 
 

i have asked that if I do go back I get the most experienced team working on me , which I don’t think is unreasonable given the circumstances 

 

my last hair cut was cut too short and was messed up, but you can see the difference in density well now . 
 

 

Did they tell you that the reason was because the team that did your first surgery at ASMED was less experienced? I probably got an even less experienced team than you did cuz I had way more hair than you before surgery and had 5000 grafts and then you had a much better result than I did. Many of my 5000 grafts died at ASMED 

I see.

so if you are with a woman or partner and they are playing with your hair looking at it or if the wind is blowing a lot does it look funny? As in there are these dark dots in your scalp that are not hairs? 
 

or when your hair is wet? 

What about when you get old and your hair turns white

On 2/24/2023 at 6:59 PM, Der3k7 said:

Do you think I should switch to duasteride xyon? Instead of the finasteride 

I asked hw and he suggested I switch over too because duasteride is better. 
 

have you ever thought about doing scalp micro pigmentation as like a “permanent topik”?

On 2/2/2023 at 12:26 PM, Melvin- Moderator said:

I got it from XYON I switched to their topical dutasteride this week. Below is a post from their patent studies. It’s super impressive.

So average ranges of DHT range from 0.38 to 3.27 nmol/L. Just so we understand.

Ok so after reading the results. This is how it’s broken down. 
 
Table 9 is looking at serum concentrations by the hour on day 28. That’s why you’re seeing an increase in serum DHT levels. So 1 hour after application the DHT levels drop than go back up after a 24 hour-period based on this graph. 

But for some their DHT levels are higher after application and gradually decrease after a 24-hour period. This reflects normal day to day fluctuations of testosterone and DHT. 


 

The graph you want to look at is table 10 which tracks DHT serum levels from day 1 hour 0 (baseline) to day 28 hour 24. 

Graph 10 subject 1. He was 1.132 at day 1 0 hours or (baseline). On day 28 (24) hours, his levels were 0.981. A 0.151 difference, which equals 15.1%.  That means his DHT levels decreased by 15% at the end of 28 days. 
 

Only three subjects saw an increase in DHT, which were both still low in the average range. Subject 6 started at 0.317 (below average range) by the end he was at 0.693. Slightly above the 0.38 average. 

Subject 8 baseline was 0.517 by day 28 he was 0.911. Subject 10 started off at 0.928 and ended at 1.118. 

Now if you look at these results at face value you might think, the dut made DHT increase. But I don’t believe thats true, to me, this looks like 3 subjects had no decrease in DHT levels. Their levels fluctuated, as they do normally without any medication. 

For some reason table 11 looks at day 1 4h as the baseline instead of day 1 0h. This skews things, you’ll see some participants levels decreased and some increased after day 1 4 hours, so it makes their increase/decrease look higher. If you look at the baseline day 1 0 hour. You’ll see the differences were negligible. 


 

Overall, the average decrease is around 10-12% depending on whether you look at baseline being 0 hour or 4 hours. This is WAY better than finasteride. No doubt about it. Its not even close. 

Do you think I should switch to duasteride xyon? Instead of the finasteride 

They better. I know it’s early but I don’t see any improvement above baseline yet

3.5 months 

quick check in

Did you notice transplanted hairs and improvement above baseline at 3 months post op at all? I’m at 3 months currently and not noticing anything above baseline yet 

3 months 

I fell off xyon for a couple weeks due to some

Personal things came up but started it up again last Sunday and have been compliant again for 4 days again. 
 

hopefully at 4 months check in I start to see improvements above baseline pre surgery and transplanted hairs start becoming noticeable 

Do you think results would be the same if I just did finasteride assuming I have no issues with it vs if I did both medications?

21 hours ago, Melvin- Moderator said:

Just received my topical dutasteride. Will be creating a video and uploading it soon! SUPER excited!! 

Are you doing both that and finasteride together?

2.5 months

returning to baseline

On 1/17/2023 at 12:01 AM, hockeyman said:

That's good. I've been on it for 4 months and I seem to be making some progress.  Application is a pain in the azz though if your hair is longer. 

Do you have a before and after? Do you have more coverage and less visible scalp now?

Looks like 5-6 months is where that cosmetic benefit first appeared really quickly for you. I’m at about 2.5 months now patiently waiting 

Just now, Melvin- Moderator said:

No, that’s a good question. As far as I’m aware, they’re 1 of 3 offering topical dutasteride. 

Are they making a topical finasteride product too? Is it better to use that and finasteride together than just finasteride? 
 

is there a specific benefit to doing topical duasteride instead of oral? And if so, why their product vs another company? Similar idea to the gel delivery system?

5 minutes ago, Melvin- Moderator said:

I don’t think it’s water soluble. It’s got to work even if it rains right? That would be pretty flawed if it doesn’t hold up. I’m thinking we should have a Q&A thread where these questions can be answered by Xyon. 

Hmm even if it’s not water soluble it could still be mechanically removed via the pressure and rubbing of getting the hair wet under the shower and drying but yeah these questions should be answered 

10 minutes ago, Melvin- Moderator said:

That's a good question. My thoughts were that it is okay to shower once it's dried, as long as you're not washing your hair with shampoo. I have been showering a few hours after applying, but only wetting my hair with water not with shampoo. I still haven't gotten any side effects. But I have a podcast scheduled to discuss the topical dutasteride. I will have all of these good questions answered. 

I think rinsing with just water would be almost as bad as washing with shampoo at removing the gel matrix on the scalp. 3 hours just seems like a lot. I remember in an interview he mentioned that the medicine is kept in a gel matrix on top of the scalp and washing it will wash the medicine away. But yeah, if you can get some more specific clarification on this that would be great.

Hey Melvin, in your discussions with Hasson did he mention at all after how many hours it is okay to shower? The pamphlet inside says apply in morning and wait to shower until afternoon or evening, but since they also say the medicine stays in a gel matrix on top of the skin and then is slow released, there must be some sort of timeline curve of the absorption over time from application until it approaches 100% has been absorbed. 

Applying in morning, say 930am, I imagine you would want to wait at least 8 hours to shower, but I am wondering if even at 8 hours if still say 40% of the medicine is left to be absorbed. What if it takes 16 hours for the full dosage to be absorbed? That could mean 16 hours of the day there is no slow release of the medicine (if showering 8 hours after application) and potentially 40% (example number) is being washed away.

I think you should trim the sides in back into a fade not necessarily a skin fade. Even just a fade into a point 5. Make the sides tighter.

 Either way that is looking nice for 4 months can’t wait to see where I’ll be I’m approaching 2.5 months from wong

I’m not doing minoxidil currently so not sure

I just asked Wong this question asking if my above statement is correct and he confirmed yes it does diffuse in the scalp. So application doesn’t have to be perfect, just try to distribute it throughout the scalp and the dosage will spread to nearby areas. Just try to make sure the spacing is sufficiently small I would say so with the diffusion of the medicine all problem areas will be dosed