90% hair coverage restoration in 15 days with MicroRNA [2020 mouse study]

[Paros]

Excerpts:

"In a 20-day trial, mice treated with the 3D DP cells had regained 90% of hair coverage at 15 days."

“MiRNAs, on the other hand, can be utilized in small molecule-based drugs. So potentially you could create a cream or lotion that has a similar effect with many fewer problems. Future studies will focus on using just this miRNA to promote hair growth.”

Here's a layman's article from May 2022 - https://www.thebrighterside.news/post/microrna-regrows-90-of-lost-hair-study-finds

Here's the original study from 2020 - Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling
Shiqi Hu, Zhenhua Li, Halle Lutz, Ke Huang, Teng Su, Jhon Cores, Phuong-Uyen Cao Dinh, Ke Cheng

Worth following up on, since the study was done 2 years ago.

 

 

 

[HappyMan2021]

i'm not a mouse though...

[Blane123]

Everything regrows hair on mouses

[AhmadChaudhry]

On 12/5/2022 at 5:43 AM, Blane123 said:

Everything regrows hair on mouses

Hi, here you can see growth / improvement in 30 days , treatment performed on human beings. 

 

[arthurSam]

Thanks you @Paros for the link, 

There are a lot of microRNA wich promote hairgrow and are found in exosomes extracted from derma papilla cells or MSC cells.

Some enchance the Wnt canonical pathway like the miR-218-5p the sudy you mention is talking about. Some have impact on other signaling pathway.

Wnt canonical signaling pathway (also called Wnt/beta-catenin pathway) is one of the major problem in balding because bald people have a deficient Wnt pathway : beta-cetenin is not accumulated in the cell nucleus because of DKK1 accumulation on balding scalp (by the way this accumulation is also correlated with DHT !).  Without the beta-catenin accumulated in cell nucleus, some gene for promoting hair grow by proliferaiton of stem cells from derma papilla during telogen phase are not transcripted. So hairs rest in telogen and go not in anagen phase... 

Some micro-RNA can induce a decrease of DKK1 and so induce a better Wnt-canonical pathway.

There are even some exosomes on derma papilla cells or MSC wich have negative impact on hair grow... but it's all very complicated and it's certainly the whole thing that counts! 

Anyway, I hope exosome treatment will work as I am currently trying it 🙂

Edited December 28, 2023 by arthurSam

[Akai]

On 9/13/2023 at 11:58 AM, AhmadChaudhry said:

Hi, here you can see growth / improvement in 30 days , treatment performed on human beings. 

 

If the lighting in the photos were the same, would the before and after pic show the same density or lack there of?

[hairman4321]

crap we should have waited for this before having a transplant

[Gatsby]

We can easily grow hair and even an ear on the backs of a mouse. However the quantum leap to replicate this on a human is still years away. 

[Worker1212]

On 1/23/2024 at 11:52 PM, Gatsby said:

We can easily grow hair and even an ear on the backs of a mouse. However the quantum leap to replicate this on a human is still years away. 

Agreed, I do wonder though if SCUBE3 is the closest? Apparently from what I read they used the drug on transplanted dormant/"dead" hair folliciles in a mouse and they successfully started to grow. Compared to other treatments it feels like this is the closest drug/hair growth stimulant that can probably save alot of people hair, or at the very least save a decent chunk of money on HT's if you either start early enough in hair loss (1-3 years) or later on in regaining some lost ground.