Regular Member Dr. William Lindsey Posted July 22, 2009 Regular Member Share Posted July 22, 2009 I posted a few months ago that I had applied for a grant to see how exactly hairs get vascularized after placement. I THINK its by a process called plasmatic imbibition, similar to what happens with skin grafts. One of our residents and I did a pretty thorough literature search and couldn't find anyone has really looked into this. So, we applied to the ISRHS and will be awarded this week a grant to investigate this. I expect to have results by next spring and if I am correct, and if we are able to see blood vessel ingrowth, the next phase will be to investigate SMOKING's effect on blood vessel ingrowth to hairs that have been transplanted. I'll periodically put up any news related to this project. It will take until October to get institutional approvals for the experiments. Dr. Lindsey McLean VA William H. Lindsey, MD, FACS McLean, VA Dr. William Lindsey is a member of the Coalition of Independent Hair Restoration Physicians Link to comment Share on other sites More sharing options...
Senior Member mmhce Posted July 22, 2009 Senior Member Share Posted July 22, 2009 Let me be the first to write on the thread and congratulate you! take care... Link to comment Share on other sites More sharing options...
Bill - Seemiller Posted July 22, 2009 Share Posted July 22, 2009 It sounds interesting Dr. Lindsey. I look forward to hearing about your findings as you begin your research. All the Best, Bill Link to comment Share on other sites More sharing options...
Senior Member thanatopsis_awry Posted July 22, 2009 Senior Member Share Posted July 22, 2009 Congrats! Look forward to seeing where you take things. ----------- *A Follicles Dying Wish To Clinics* 1 top-down, 1 portrait, 1 side-shot, 1 hairline....4 photos. No flash. Follicles have asked for centuries, in ten languages, as many times so as to confuse a mathematician. Enough is enough! Give me documentation or give me death! Link to comment Share on other sites More sharing options...
Regular Member Dr. William Lindsey Posted July 23, 2009 Author Regular Member Share Posted July 23, 2009 Essentially we are taking an animal model, rodent of some sort, and doing a small 20 graft transplant. Then we kill the animal at day 1, 3, 5, 7, 9 and histiologically look at blood vessel ingrowth. In skin grafts, new blood vessels grow in in about 5 days. It will take very few rats to show this. Then, if this is successful, we can try the same experiement with a variety of variables, such as nicotine, low light laser therapy!!?, vasodilators, copper peptides... You must realize, we aren't splitting the atom, but rather focussing on a short experiment to answer a focussed clinical question. I expect, and hope, that we can accomplish something worthwhile. Dr. Lindsey McLean VA William H. Lindsey, MD, FACS McLean, VA Dr. William Lindsey is a member of the Coalition of Independent Hair Restoration Physicians Link to comment Share on other sites More sharing options...
Senior Member PLEASE GROW PLEASE Posted July 23, 2009 Senior Member Share Posted July 23, 2009 Then we kill the animal at day 1, 3, 5, 7, 9 I dont know why that that made me laugh ,but it did. Make sure its a possum if possible Congrats on the grant Link to comment Share on other sites More sharing options...
Senior Member mmhce Posted July 23, 2009 Senior Member Share Posted July 23, 2009 Then we kill the animal at day 1, 3, 5, 7, 9 Yeah,it's kinda funny; a very non-clinical way of saying euthanasize. take care... Link to comment Share on other sites More sharing options...
Senior Member HairHope Posted July 23, 2009 Senior Member Share Posted July 23, 2009 This manuscript may provide some useful ideas, especially in terms of design and measurement. Also, some good preliminary data perhaps to help you with sample size estimates and expected effect estimates. Control of hair growth and follicle size by VEGF-mediated angiogenesis Kiichiro Yano1, Lawrence F. Brown2 and Michael Detmar1 1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA 2Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA http://www.jci.org/articles/view/11317/version/1 Dec. 2004 - 1938 Grafts via Strip Feb. 2009 - 1002 Grafts via FUE Link to comment Share on other sites More sharing options...
Regular Member Fookinhair Posted July 23, 2009 Regular Member Share Posted July 23, 2009 Then we kill the animal at day 1, 3, 5, 7, 9 Dr. Lindsey McLean VA I have a question. How do you get the dead animal back to life again after killing it at days 1,3,5 & 7? Link to comment Share on other sites More sharing options...
Senior Member Reverse the Curse Posted July 23, 2009 Senior Member Share Posted July 23, 2009 dr l will the grafts be in the hairline or will you try to create a swirl in the crown? hmmm just curious where does the hairline start on a rat? at the top of the nose? above the eyes? rtc good luck with your research Link to comment Share on other sites More sharing options...
Senior Member PLEASE GROW PLEASE Posted July 23, 2009 Senior Member Share Posted July 23, 2009 Originally posted by Fookinhair: Then we kill the animal at day 1, 3, 5, 7, 9 Dr. Lindsey McLean VA I have a question. How do you get the dead animal back to life again after killing it at days 1,3,5 & 7? I heard mouth to mouth Im sure if Jesus could raise Lazarus from the dead Dr Lindsey could raise a rat Link to comment Share on other sites More sharing options...
Regular Member Fookinhair Posted July 23, 2009 Regular Member Share Posted July 23, 2009 Thanks for clearing that up PGP. I can sleep easier tonight. Link to comment Share on other sites More sharing options...
Regular Member Dr. William Lindsey Posted July 24, 2009 Author Regular Member Share Posted July 24, 2009 Actually, in rodents the swirl is counterclockwise. Maybe that is what George Costanza was talking about... Dr. Lindsey McLean VA William H. Lindsey, MD, FACS McLean, VA Dr. William Lindsey is a member of the Coalition of Independent Hair Restoration Physicians Link to comment Share on other sites More sharing options...
Regular Member alex85 Posted December 27, 2021 Regular Member Share Posted December 27, 2021 @Dr. William LindseyI know this is a old post, but I am really curious what the conclusion of this study was. Are the results ever published? Link to comment Share on other sites More sharing options...
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