JP28

https://www.scalpmicrosd.com/ go on their IG they have some examples of smp on fue scars like this one  https://www.instagram.com/p/CMxfO46nEJ5/?utm_medium=copy_link

40 minutes ago, TorontoMan said:

Wow what a difference. Did your hair get to this point before finasteride ?

 

& my opinion is to just stay off creatine. If it has any chance of ruining your hair then I don’t see the point 

I have to agree with him, it’s just not worth it. 

3 hours ago, Melvin- Moderator said:

Based on what Dr. Charles said about TRT, he feels that fin is enough to inhibit DHT for most, but it comes down to your sensitivity to the androgen. For example, if you’re a guy with aggressive hair loss, probably not a good idea. If you’re a guy with minor hairline recession and everything else in tact and healthy, fin is probably enough to inhibit DHT from affecting your hair. It really is dependent on the individual.

Very interesting Melvin, so let me ask you a question then, I’m part of the minor hairline recession(I mean I was) so are you saying that for some people a reduction of only 40% of scalp dht would be enough to completely stop hair loss caused by dht? 

thanks 

2 minutes ago, TorontoMan said:

Very solid. 
 

I’ll look into lipogaine myself. Are you using Cetirizine for inflammation? 
 

lol good to see my post impacted, I have the A6 pen as well. My tip for microneedling is that more is not necessarily better. Keep it under 10 minutes and don’t overdo it, we want to wound but not damage skin over time. I would also look to cycle needling, do it for 6 months and then come off for 3-4 months. 

 

And as per ru, it has a short half life so if it was being used as mono therapy than I would say you would need it every day, but because you’re on fin/ duta i wouldnt worry about missing a day in between 

I’ve been using cetirizine for allergy for a little while now but it was always just for a few months or when I felt that I needed it but few days ago someone sent me that: https://www.practiceupdate.com/content/topical-cetirizine-in-the-treatment-of-androgenetic-alopecia/65678

so I decided to take it yearly, it definitely helps with inflammation and itching.

I’ll follow your advice for microneedling!

yes for ru It would totally work for me if it’s fine eod, I was just worried about making things worse by skipping a day. 

1 hour ago, TorontoMan said:

Current Prevention - 1mg Fin, 2.5mg Oral Min, Topical 5% Minoxidil 1x a day, Needling every 10 days 1.5mm, Nizarol once every two weeks or as needed. 

* Note - I use to use nizarol once a week, and midweek I would use Regenpure's 1% Keto shampoo, but have recently dropped it as its been clearly drying my scalp and hair making it feel weak and look frizzy. I will only use Nizarol now sparingly and mainly when I feel my scalp becomes irritated as it its really great at clearing any dandruff or seb dermatitis.

Adding to Prevention - 

2% (20mg) RU58841 in 1.5 ml PG + ETH.
(experimental chemical, not approved for hair loss) 

- Trialing a topical anti androgen to compete with residual DHT and Testosterone in the scalp. 
- Minimal dose of RU, as I don't believe its necessary to go any higher due to its high binding affinity at first pass. 
- I also have fluridil powder which I intend to trial at >5% dose if I don't comply with RU. 

Excited for the future - 

1. BAY 1159061 - Bayer's prolactin receptor antibody 
If you're not familiar with this then I highly recommend you read up on the product. Bayer struck a licensing agreement with a Chinese company named Hopemed and raised $56 million dollars for this project, it is currently in phase 2 trials and the results will likely be published end of this year or early next year. The prolactin angle to combatting hair loss has been all the rage recently as it it is thought that prolactin made locally in the hair follicle is inhibiting stem cells in the follicle by shutting down their signalling. The antibody being developed is thought to be very selective for the PRL receptor so that it binds and stops PRL from exerting its negative effects on the follicle, which would in turn allow for things like WNT signalling to take place and other stem cell signalling. Androgens and PRL may have a synergistic effect on your hair, so reducing androgens and inhibiting the PRL receptor with BAY could theoretically "reset balding". 

“The PRL receptor antibody is a potent monoclonal antibody, blocking the PRL receptor-mediated pathway in a non-competitive manner. The drug product can be administrated subcutaneously. The antibody was well tolerated in a clinical Ph I study (combined single and multiple dosing).

The antibody was effective in stimulating hair growth in aged stump-tailed macaques, nearly doubling the number of terminal hairs after 6 months even in previously fully bald areas and showing a sustainable impact even after 2 years post treatment. Notably, the stump-tail macaque model is considered one of the rare predictive animal models for male and female pattern hair loss in humans. The study is a result of a close collaboration between Bayer scientists and researchers at IMM.”

https://www.folliclethought.com/bayer-licenses-hair-loss-treatment/

This is a very promising upcoming treatment and in my opinion might even turn out to be a functional cure for most men. It is hopefully only 2-4 years away from market, and in my opinion it is worth holding out any hair transplants until we get more results and information from trials as it could have great potential for regrowth

2. Kintor Pharma's AR antagonist (pyrilutamide) and AR degrader (GT20029)

https://www.hairlosscure2020.com/kintor-pharmaceutical-from-china/

^ Well written write up on the two products and how they're progressing. 

The AR degrader is thought to have potential to reduce the AR sensitivity, this means that your hair folicles will be less prone to the effects of DHT and test. Of course in theory, if this is safe, this will be a major step forward. The AR antogonist will be similar to any topical AA like RU for example, but we will likely have a better understanding of its binding affinity and safety profile for those who are concerned. This is already in phase 2 in China and has entered phase 1 in the US. Its also thought to have a greater binding affinity than CB & FLuridil with similar safety profile

Other compounds being discussed and trialled anecdotally by guys across other forums are:

SMI-6 - mimics the effects of BAY on the PRL receptor

WAY-200070 - ERb antagonist to induce estrogen type effect on hair (estrogen is good for hair) without acting on the ERa which is what would give feminizing side effects from increasing estrogen levels. 

* ^These two are not something I'm trialing myself, but just something for you to take note of and read up on as more info comes in. 

Lastly, topical dutasteride is getting a lot of attention in the last couple of years. H&W clinic are apparently trialing their own formulation currently and are looking to release a small study they've done by the end of this year. More could be found on topical dutasteride online. 

 

There it is, this was a bit manic and it felt like I was writing up a small research paper for uni, but I wanted to do my service to the forum as it really helped me from the beginning. I'm very optimistic that this is an exciting time for hair loss as there are so many things in the pipeline, more than I even mentioned here.  

Thanks for that write up man, very helpful.

I’ll be doing my first session of micro needling tonight as I just received my dr.pen A6 that I ordered after seeing your post.

I’ve done some change to my regimen as well.

-1.25 fina ed

-0.6 mg duta once a week

- keto shampoo 3x week (lipogaine) doesn’t dry my hair at all and I have very dry hair.

-ceterizine 10mg daily 

-oral minox 1.25 daily 

-topical minox 5% once a day 

-oral castor oil 2ml ed 

-micro-needling once a week 

I’m also thinking to add ru but I wouldn’t want to use it everyday, do you think that’s an option? 
 

Thanks 

10 hours ago, bald-and-bearded said:

any examples of his?

2 hours ago, mustang said:

It's not, their survival rate is outstanding. 

If you didn't have a good experience fair enough, I didn't have a great experience either with them but their work is fantastic and irrefutable both on survival rates and extraction. Not cool to lie.

Were they the one that messed up your temple points or was it another clinic in Turkey? 
just curious cause they seen to do a great job indeed. 

Mwamba is definitely one of the best at bht.

I’d definitely go with HLC if I was to go in Turkey.

3 hours ago, TorontoMan said:

Thank you! I think I waited about a month and a half to do the rest of my head other than the recipient. I didn’t needle the recipient until 3 months. Just personal choice and also paranoia. 

Thanks for the answer!

I’ll probably restart very soon then, I’m a bit like you “paranoid” particularly cause I’m 3 months post HT so I might wait for most of it to be out. 

1 hour ago, mustang said:

Maybe you should ask them to ship with DHL, takes about 3 days but it's over 40 EUR

Only worth it if you are buying multiple bottles. 

Parati sends with DHL to the US as well, have you asked them?

Thanks! Yes I just did.

3 minutes ago, JohnAC71 said:

No grafts will fall after becoming secure. No grafts are falling here 🙏

I meant if the hair fall after 10 days there is no need to worry, that was my question? 😥 

2 minutes ago, JohnAC71 said:

 

7 hours ago, JohnAC71 said:

Can I ask who the clinic was ? Your grafts will be fine and they were very secure by day 10. I can see normal scabbing occurring it’s the lotion that needs to be properly removed. The Post op video that Melvin posted above shows decent after care ! 🙏

Hi John, so graft falling after 10 days are fine? 

@TorontoMan looks greats man, when did you start micro-needling after your HT?

Thanks  

1 hour ago, mustang said:

I have no problem waiting 3 weeks to get it. It's the best compound I have tried.

Also I can't agree with you on this one. Dr Mwamba and their team are extremely warm and nice people, I had 4 surgeries with them,never had bad customer service from them.

You can get it from Parati as well! 

I love Dr.Mwamba is great, such a lovely man I also had surgery with him and will go back again for sure, I wasn’t referring to him or his team at all but more the whole Dutasteride operation with Joshua. 

5 minutes ago, mustang said:

No need to wait for them, plenty of good suppliers out here! 

Got the one from fue-clinic, excellent product but awful customer service and over 5 weeks to receive so this one is out of the question, in the states we have strut I might just get this one. 

1 minute ago, mustang said:

When on TRT CB0301 7.5%

Some people use oral 5 days a week and Topical twice a week 

I might just do that! Can’t wait for Hasson&Wong to come up with their topical! 
 

Thanks 

Just now, mustang said:

Probably the same but systemic reduction is 90% on oral vs 10-20% on Topical

Thank you mustang! So no point for me to add topical duta if I’m already using the oral.

May I ask you what are you using as a topical AA? 

42 minutes ago, mustang said:

I have been bullied to death for being an advocate of Topical Dutasteride once a week.

I am really happy to see Dr Wong making this statement. 

Would you say that topical Dutasteride blocks more scalp dht than the oral version or it’s about the same? 
 

thanks 

On 7/18/2021 at 10:25 AM, PT#31 said:

Please see below. Right after the second day of surgery. Super clean, in my opinion. Dr. BF told me that I should have a buffer of more c. 2000 grafts in case I would like to reinforce a specific zone, in the future (that’s not my intention).

Result looks amazing! I like that he’s not scared to take graft higher, I think if I need another ht I’ll go with him!

what size punch is he using? 

Outstanding result with a very descent amount of graft! 
 

Why can’t all surgeons do a presentation like that? Is it that difficult seriously?

No wonder is booked till 2023 

6 minutes ago, giegnosiganoe said:

You've got beautiful looking hair! I'm sure with every day usage of DHT blockers, you will prevent almost all further loss. Personally, I would not bother with the laundry list of items in your regimen.

Better safe than sorry right 😁

On 7/9/2021 at 6:44 PM, giegnosiganoe said:

Do you have any before/after pics? Considering you started medication at only age 17, I'd imagine you prevented any loss from occurring?

Sorry didn’t see your post, it did and I probably wouldn’t have lost anything had I taken it every day when I started, not that I didn’t want to but it was a pain in the old world and also 13 years ago to get a prescription so I would take it every 3 days, I started taking it every day 3 years ago.

I started oral duta on Friday and will be taking it every 3 days, the other days just fina and once a week I’ll add topical duta(home brew till I can get a liable source) 

only once I stopped for few months and paid the price right away so had to get a hair transplant 3 month ago now. 
 

14 minutes ago, PelazoVenAMi said:

At the moment:

 Oral dutasteride 5 times a week.
 Oral minoxidil every day.

 Topical dutasteride 0.1% twice a week (I'm giving it on the days I don't take oral dutasteride).

 Mesotherapy Dutasteride 0.05%: I started giving it once a month, but the doctor saw the improvement and that it did not affect me, he increased it to once a week this month.  

 

Thank you very much for commenting and encouraging me!  A hug!

A ti! 
 

I started oral duta today after 13 years of fina.

Un abrazo