Senior Member deeznuts Posted February 10, 2021 Senior Member Share Posted February 10, 2021 Does non-liposomal topical finasteride make a difference compared to liposomal finasteride? I think I got a prescription for non-liposomal topical finasteride... I was wondering if that would affect how much of it my body absorbs. Link to comment Share on other sites More sharing options...
Senior Member Future Hair Doc Posted February 10, 2021 Senior Member Share Posted February 10, 2021 Liposomal finasteride is better absorbed and thus more effective than non-liposomal finasteride. My advice does not constitute a patient-physician relationship nor as medical advice and all medical questions/concerns should be addressed to your medical provider. Link to comment Share on other sites More sharing options...
Senior Member deeznuts Posted February 10, 2021 Author Senior Member Share Posted February 10, 2021 4 hours ago, Dr. Suhail Khokhar said: Liposomal finasteride is better absorbed and thus more effective than non-liposomal finasteride. Do you know if it affects the amount of side effects that the user experiences? Link to comment Share on other sites More sharing options...
Senior Member Future Hair Doc Posted February 10, 2021 Senior Member Share Posted February 10, 2021 Topical finasteride won't have systemic side effects since it's not systemically absorbed, it's locally absorbed. The only side effects I've seen from topical finasteride is irritation around the scalp and that is likely due to scalp sensitivity to a component mixed in with the topical finasteride, such as as alcohol. My advice does not constitute a patient-physician relationship nor as medical advice and all medical questions/concerns should be addressed to your medical provider. Link to comment Share on other sites More sharing options...
Senior Member Style22 Posted February 11, 2021 Senior Member Share Posted February 11, 2021 Dr. Khokhar, I see you post this as if it were fact all the time on this site... Every single Topical fin study I have seen shows Systemic reduction of dht. Similar to if not greater than oral fin. Am I missing something? Is there a topical fin compound that has any sort of data to back these claims? Not doubting your clinical experience but the data would suggest otherwise stating that there is no systemic absorption of topical fin. I myself struggle with Fin sides so I am certainly looking into these topical options heavily right now. Link to comment Share on other sites More sharing options...
Regular Member Gokul Krishnan Posted February 23, 2021 Regular Member Share Posted February 23, 2021 On 2/11/2021 at 5:52 AM, Style22 said: Dr. Khokhar, I see you post this as if it were fact all the time on this site... Every single Topical fin study I have seen shows Systemic reduction of dht. Similar to if not greater than oral fin. Am I missing something? Is there a topical fin compound that has any sort of data to back these claims? Not doubting your clinical experience but the data would suggest otherwise stating that there is no systemic absorption of topical fin. I myself struggle with Fin sides so I am certainly looking into these topical options heavily right now. yes. I am really skeptical when someone says topical finasteride has NO side effects. Need more data to be conclusive. Link to comment Share on other sites More sharing options...
Senior Member Future Hair Doc Posted February 25, 2021 Senior Member Share Posted February 25, 2021 On 2/10/2021 at 7:22 PM, Style22 said: Dr. Khokhar, I see you post this as if it were fact all the time on this site... Every single Topical fin study I have seen shows Systemic reduction of dht. Similar to if not greater than oral fin. Am I missing something? Is there a topical fin compound that has any sort of data to back these claims? Not doubting your clinical experience but the data would suggest otherwise stating that there is no systemic absorption of topical fin. I myself struggle with Fin sides so I am certainly looking into these topical options heavily right now. Please post those studies so I can take a look. How would a local medicine reduce DHT more than a systemic medicine? That premise doesn't make any sense. It's like saying topical neosporin will kill more bacteria in your body than an IV antibiotic. My advice does not constitute a patient-physician relationship nor as medical advice and all medical questions/concerns should be addressed to your medical provider. Link to comment Share on other sites More sharing options...
Senior Member Future Hair Doc Posted February 25, 2021 Senior Member Share Posted February 25, 2021 On 2/23/2021 at 2:57 AM, Gokul Krishnan said: yes. I am really skeptical when someone says topical finasteride has NO side effects. Need more data to be conclusive. I said systemic side effects, I didn't say NO side effects. That's a big difference. The only side effect I've seen is irritation/itching due to contact dermatitis. My advice does not constitute a patient-physician relationship nor as medical advice and all medical questions/concerns should be addressed to your medical provider. Link to comment Share on other sites More sharing options...
Regular Member Gokul Krishnan Posted February 25, 2021 Regular Member Share Posted February 25, 2021 1 minute ago, Dr. Suhail Khokhar said: I said systemic side effects, I didn't say NO side effects. That's a big difference. The only side effect I've seen is irritation/itching due to contact dermatitis. Yes. I got your point. I am skeptical that it has no systemic side effect. Not an expert, but my thoughts are when used for long periods some amount of finasteride will get accumulated in system and it will take months or years for systemic side effects to show. Link to comment Share on other sites More sharing options...
Senior Member Future Hair Doc Posted February 25, 2021 Senior Member Share Posted February 25, 2021 (edited) 1 hour ago, Gokul Krishnan said: Yes. I got your point. I am skeptical that it has no systemic side effect. Not an expert, but my thoughts are when used for long periods some amount of finasteride will get accumulated in system and it will take months or years for systemic side effects to show. Drugs have half-lives because they're cleared by the body (whether it's by the liver through the cytochrome p450 pathway, kidneys, etc). Topical finasteride will not accumulate in our body to enough a significant degree to cause systemic side effects. Please share a study in a reputable journal that shows topical finasteride has systemic side effects. I'm sure there are RARE cases of hypersensitivity reactions, but thankfuly, I haven't come across any such cases in my patients. Every doctor with decades of more experience than me that I've talked to hasn't had a patient with systemic side effects. I'm a big proponent of science. If there's science behind your assertion, please share it. Edited February 25, 2021 by Dr. Suhail Khokhar My advice does not constitute a patient-physician relationship nor as medical advice and all medical questions/concerns should be addressed to your medical provider. Link to comment Share on other sites More sharing options...
Senior Member Style22 Posted February 25, 2021 Senior Member Share Posted February 25, 2021 7 hours ago, Dr. Suhail Khokhar said: Please post those studies so I can take a look. How would a local medicine reduce DHT more than a systemic medicine? That premise doesn't make any sense. It's like saying topical neosporin will kill more bacteria in your body than an IV antibiotic. I’ll post some and have you take a look. See what you think. Medicines used locally do go systemic. Why else would we rub testosterone cream on our shoulders and balls? Sure the injections and orals have a far greater effect systemically. i have zero doubts that some off these topical formulations do a much better job than others of staying local. Link to comment Share on other sites More sharing options...
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