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New hairloss solution? JAK inhibitors for topical application?

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For people with hair loss, a promising option | Zee News

 

n experiments with mouse and human hair follicles, Angela M. Christiano and colleagues found that drugs that inhibit the Janus kinase (JAK) family of enzymes promote rapid and robust hair growth when directly applied to the skin. The study raises the possibility that drugs known as JAK inhibitors could be used to restore hair growth in multiple forms of hair loss such as that induced by male pattern baldness, and additional types that occur when hair follicles are trapped in a resting state. Two JAK inhibitors have been approved by the U.S. Food and Drug Administration.

One is approved for treatment of blood diseases (ruxolitinib) and the other for rheumatoid arthritis (tofacitinib). Both are being tested in clinical trials for the treatment of plaque psoriasis and alopecia areata, an autoimmune disease that causes hair loss.

"What we've found is promising, though we haven't yet shown it is effective for male pattern baldness," said Dr. Christiano. "More work needs to be done to test formulations of JAK inhibitors specially made for the scalp to determine whether they can induce hair growth in humans."

The research is published in the online edition of Science Advances.

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For people with hair loss, a promising option | Zee News

Two JAK inhibitors have been approved by the U.S. Food and Drug Administration.

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If these inhibitors have been cleared by the FDA I assume it's either already on the market or it's on its way there with no ETA of arrival. Any possibility for use as an off-the-shelf medication with the intention of using it on the scalp for the sake of experimentation for hair regrowth? At this point I can be a guinea pig and report back any findings I may observe in the name of hair science.

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Alopecia areata is an auto-immune disease that responded well to this arthritic medication. There was a ton of press on this. MPB is genetic and completely different mechanism. The two are not related. Would be very surprising to see the same impact on MPB.

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Hair loss is a critical situation where person's emotions and mental strength disrupted. However, the hair loss during breast feeding is due to many reasons.This might be due to hormonal imbalance, weakness and loss of concentration. If are concerned about nioxin then it has no effects or it may have some effects. It varies from person to person.

for me i use coal tar shampoo For Hair fall

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@yassine,

 If your intention here is to promote and link to products that you are selling, then you’re gonna have to pack it up and go somewhere else. This forum community is not a venue to promote treatments or products of any kind. You may discuss it and share your experience which is what the purpose of this form is for. But hotlinking certain terms to wear a product can be purchased is an obvious SEO tactic that  is in violation of our terms   

Best regards,

bill


I am the managing publisher of the Hair Transplant Network, the Hair Loss Learning Center, the Hair Loss Q&A Blog and this Hair Loss Forum. I am also a 4 time hair transplant patient. View my patient hair loss website to view my entire hair restoration journey with photos.

Remember, true beauty radiates from within, not from the skin.

I am not a medical professional and my words should not be taken as medical advice. All opinions and views shared are my own.

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