jondoeuk

ProStrakan, the company that eventually acquired the rights to PSK-3841 (aka RU-58841), ran two clinical trials in humans in the early to mid 2000s. The first was a PhI (n=30) and the second was a randomised and placebo controlled PhII (n=120), but results were never published, nor did a pivotal trial start to bring it to market. Now we have (non-)steroidal antiandrogens with published clinical data, which are fluridil, clascoterone (CB-03-01) and pyrilutamide.

Tretinoin upregulates follicular sulfotransferase enzymes, which metabolise minoxidil to its active metabolite, minoxidil sulfate Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes - Sharma - 2019 - Dermatologic Therapy - Wiley Online Library

It (5 mg) was first approved by the FDA for treatment of benign prostatic hyperplasia (prostate enlargement) back in 1992. This is an interesting study on the nocebo effect https://academic.oup.com/jsm/article-abstract/4/6/1708/6890112

The current version is 2%, but I know actifolic are selling 5%, 8% or 10%, which could improve efficacy.

From eucapil-shop?

Has anyone used dutagen by hemiacosmetics or duderma by minoxidilmax?

I'll leave this

No, the grey market. Also, it is generally well-tolerated, with the most common adverse events being localised, such as contact dermatitis.

Thanks. Do you know about some of the others, such as dutagen and lrak tech?

From this: ''Sexual functions, libido, hematology, and blood chemistry values were normal throughout, except that at 3 months, in the spring, serum testosterone increased within the normal range equally in placebo and fluridil groups. No fluridil or its decomposition product, BP-34, was detectable in the serum at 0, 3, or 90 days.'' Fluridil, a Rationally Designed Topical Agent for Androgenet... : Dermatologic Surgery (lww.com) I'm not aware of the company behind CosmeRNA doing the same.

Anyone using duderma?

Anyone used it? If so, results and any sides?