It’s generally just trial and error. I tried 1mg/day and got minor sides, stopped for a few weeks and tried 0.5mg/day still the same, then 0.5mg/eod with sides again. I again stopped for a few weeks then tried 0.25mg/eod about 3 months ago with No sides, I have just increased it to 0.25mg 5 days a week and as long as I stay free from sides I will remain on this dose. Everybody’s different and it’s sometimes just finding the right dose for you, but some is better than none.