Regular Member jim1973 Posted July 30, 2023 Regular Member Share Posted July 30, 2023 It seems that unless Minoxidil converts to Minoxidil Sulfate, that it won't work. That said, it seems that there used to be products in early and mid-2000s, that sold as Minoxidil Sulfate products but I don't see those advertised anymore. If Minoxidil only works for those who have the needed enzyme to convert to Minoxidil Sulvate, why not just purchase and apply Minoxidil Sulfate directly to avoid the need for a specific enzyme that only 50% of people have? Are there no existing products selling Minoxidil Sulfate? Link to comment Share on other sites More sharing options...
Valued Contributor A_4_Archan Posted July 30, 2023 Valued Contributor Share Posted July 30, 2023 (edited) @jim1973minoxidil sulphate has a way higher molecular weight and that's why there will be an absorption issue...so due to low absorption potential a higher concentration of minoxidil sulphate need to be used which can lead to other issues.... Edited July 30, 2023 by A_4_Archan 1 Check Out My Hair Transplant Journey --> My Thread 3611 FUE Grafts With Dr Kongkiat Laorwong | Norwood 5 | 2nd May 2023 Link to comment Share on other sites More sharing options...
Regular Member jondoeuk Posted July 30, 2023 Regular Member Share Posted July 30, 2023 Tretinoin upregulates follicular sulfotransferase enzymes, which metabolise minoxidil to its active metabolite, minoxidil sulfate Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes - Sharma - 2019 - Dermatologic Therapy - Wiley Online Library Link to comment Share on other sites More sharing options...
Senior Member GoliGoliGoli Posted July 30, 2023 Senior Member Share Posted July 30, 2023 2 hours ago, jondoeuk said: Tretinoin upregulates follicular sulfotransferase enzymes, which metabolise minoxidil to its active metabolite, minoxidil sulfate Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes - Sharma - 2019 - Dermatologic Therapy - Wiley Online Library Is anyone selling a good minox/tret foam or liquid? Link to comment Share on other sites More sharing options...
Valued Contributor Gatsby Posted July 31, 2023 Valued Contributor Share Posted July 31, 2023 Unless you can't tolerate oral minoxidil then oral minoxidil converts to minoxidil sulphate because it passes through the liver. That's why more people respond well to oral minoxidil than topical minoxidil. GATSBY 'UNPLUGGED!' 15,671 (3 surgeries) Grafts FUE+BHT Dr. Sethi Eugenix Link to comment Share on other sites More sharing options...
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