Can Dutasteride work just topically for hair loss without going systemic to lower DHT?

[12345]

I'm late to this topical dutasteride game, so forgive me if these questions are too newbie.

But can dut really work topically to inhibit the 5 alpha-reductase inhibitors on the scalp and not have to go systemic to lower DHT?

 

 

[TorontoMan]

That's what we're all tryna figure out brother, have a look at this thread here: 

 

[TorontoMan]

or this: 

 

[Melvin- Admin]

In theory, yes. But there’s no solid evidence. Anecdotally, I’ve been on it a few months. No side effects, hair feels better, but hard to say for sure. At worst, I think it’s maintaining my hair, at best, seems to thicken some thinning areas. 
 

I feel a noticeable difference between the fin and dut. I do believe side effects can occur more with finasteride because it absorbs more easily. Dut absorbs slower and it doesn’t penetrate as deep due to the dalton size (theoretically). I think dut is the best topical on the market, though, CosmeRNA just came out, so that may be a contender.