Senior Member KO Posted December 6, 2014 Senior Member Share Posted December 6, 2014 "May contribute", however I've posted two studies where they've actually looked at insulin resistance and both found none. Now as hairweare says, this is a small sample size and no control....but still they found no difference. 3382 FUE Lupanzula http://www.hairrestorationnetwork.com/eve/185463-3382-grafts-lupanzula.html Link to comment Share on other sites More sharing options...
Senior Member hairweare Posted December 6, 2014 Senior Member Share Posted December 6, 2014 In my field of specialization very large multi- center RCTs were performed over many years but even so much of the data has later come into question when yet another similar trial demonstrated disparate results. I have not been satisfied with what I have seen in regard to the scientific data pertaining to adverse effects from 5aR inhibition. Any biologic process which involves hormones, active metabolites, enzymes, multiple and diverse tissue receptor sites will have confounding variables, dose and idiosyncratic variabilities due to differences in genomes that cannot be reasonably expected to be resolved by such small uncontrolled non randomized studies. Personally, I remain concerned but more so frustrated by the lack of dependable medical evidence that address the long term safety issues of DHT inhibitors. That being the case in no way would I regard the advice of a supplement salesman with no scientific background as being either useful or legitimate. Link to comment Share on other sites More sharing options...
Senior Member mikeey Posted December 11, 2014 Senior Member Share Posted December 11, 2014 For Me Propecia is a Killer , I Never Touch it , Hair is important , but not at the expense of fucking your Body ..... No Sir , I am already a Norwood 2 , But still I am on saw palmetto dunno if it does anything , But I am just trying to Maintain My Hair from future Damage. Link to comment Share on other sites More sharing options...
Senior Member hairweare Posted December 11, 2014 Senior Member Share Posted December 11, 2014 For saw palmetto to be efficacious it would block 5ar1 to the same extent as finasteride does. Inhibition of an enzyme is not a "natural" process so whether the agent was derived from tree bark, animal dung or made in a test tube makes little difference. Both efficacy and incidence/severity of side effects would be similar. If on the other hand it has no significant effect on decreasing circulating DHT then you are wasting your time and money taking it. Link to comment Share on other sites More sharing options...
Senior Member Swooping Posted December 15, 2014 Senior Member Share Posted December 15, 2014 (edited) If you have troubles with side effects on propecia and don't see a other way around I would strongly suggest anyone to look intro RU-58841. Although it is an "experimental" the compound is way more exciting than propecia. Anecdotally, it seems to do a better job both in terms of effectiveness & side effects. Edited December 15, 2014 by Swooping Proud to be a representative of world elite hair transplant surgeon Dr. Bisanga - BHR Clinic. Hairtransplantelite.com YouTube Online consultations: damian@bhrclinic.com Link to comment Share on other sites More sharing options...
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