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Peter88

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  1. Hope2win, I started to take original Propecia 10 years ago. 5 years ago I started to buy online. I know it is not the safest way but it is cheaper. My personnal experience with both online pharmacies has been good so far. If you live in a country that you don't need prescription to buy finasteride so the best you can do is to buy generic Proscar in a local pharnmacy and cut the pills in 4. If it is not the case you can try to carefuly buy online. Good luck!
  2. SRK735 Usually buy propecia (generic) online from 4rx (also have generic porscar) but I have also bought generic Proscar from Quality-rx with no problems too. Both are Canadian online pharmacies I think... http://www.4rx.com/online-phar...cia.html?affId=79599">Propecia http://www.quality-rx.com/pres...ns/proscar/?fid=5144
  3. VeniVidiVici I have 2 childrens. No problem to conceive
  4. 9 years on finasteride Just a small reduction of volume ejaculated in the beginning. No side effects now.
  5. Bill I take finasteride for 10 years. Now I have 2 childrens (One girl with 3 years and a boy with 2 months). 4 years ago I had the same concern about Propecia. I sent an email to Dr. Lee and he answered me the next. I discontinued to use of Propecia 1 month before conceiveing. This could be "important" if you have a small volume reduction on sperm ejaculated like I used to have (not now). I returned to finasteride after conceiveing and fortunately with no problems for the kids. Good luck! FINASTERIDE AND BIRTH DEFECTS There are very few more anxiety provoking times in anyone's life than possibly causing a birth defect in one's own unborn child. So, it's quite understandable that the mention of a possible birth defect with the use of finasteride (Propecia 1mg and Proscar 5mg, Merck) would cause considerable anxiety and concern. The package insert for Proscar states under the section on Contraindications: 'Because of the ability of Type II 5alpha reductase inhibitors to inhibit the conversion of testosterone to DHT, finasteride may cause abnormalities of the external genitalia of a male fetus of a pregnant woman who receives finasteride'. So, is the risk real? Theoretically, yes. Practically, no. The specific birth defect that can be caused by the absence or inhibition of the Type II 5-alpha reductase enzyme in the male embryo is hypospadias. Hypospadias is a birth defect in which the urinary tract opening is on the ventral surface (under side) of the penis rather than at the tip of the penis. There have never been congenital abnormalities observed in female fetuses at any dosage of finasteride. During the research and development phase of finasteride, studies were done on experimental animals. Rats, rabbits, and rhesus monkeys were given finasteride to determine its relationship to birth defects, i.e. hypospadias. Hypospadias did occur in the male offspring, when pregnant rats were administered finasteride equivalent to 5-5000 times the amount of recommended for men in treating MPB (1mg/daily). The critical period during which these effects can be induced in male rats was determined to be during the 16th ??“17th days of gestation. In rabbit fetuses exposed to finasteride in utero from days 6-18 of gestation at doses equivalent to 5000 times the recommended human dosage, no evidence of malformations was observed. This result would be expected, since there was no exposure during the critical period of genital system development in rabbits. When pregnant rhesus monkeys were given intravenous finasteride at a level equivalent to at least 750 times the highest estimated exposure of pregnant women to finasteride from semen of men taking 1mg/day, there were no genital abnormalities observed. In the human embryo, the sensitive period of external genitalia development is during the 7th - 9th weeks of gestation. Although the chromosomal and genetic sex of an embryo is determined at fertilization by the kind of sperm, either Y-bearing or X-bearing, that fertilizes the ovum, male and female morphological characteristics do not begin to develop until the seventh week. Prior to this time, the genital systems of the two sexes are similar, and the initial period of genital development is referred to as the 'indifferent state of sexual development'. About six weeks after conception, if a Y chromosome is present in the embryo's cells (as it is in normal males), a gene on the chromosome directs the undifferentiated gonads to become testes. If the Y chromosome is not present (as in normal females), the undifferentiated gonads will become ovaries. If the gonads become testes, they begin to produce androgens, primarily testosterone, by about eight weeks after conception. These androgens stimulate development of the one set of the genital ducts into the epididymes, vas deferens, and ejaculatory duct. The presence of androgens also stimulates development of the penis and the scrotum. Hypospadias can result if there is inadequate production of androgens by the fetal testes. Since the sensitive period of development of the external genitalia in the human embryo is the 7th to 9th weeks of gestation, there can be no danger to the child if the father is taking finasteride at the time of conception. Originally, Merck decided to err on the side of caution and warned against the possible problem of finasteride transfer in semen. This warning has since been removed from the package insert. Considering the medical/legal implications of a theoretically possible link of finasteride treatment to birth defects, it is reasonable to assume that Merck & Co. must be very confident in knowing that impregnating a woman while taking finasteride absolutely does not cause birth defects. Nor is there any evidence of birth defects when the father taking finasteride has intercourse with the pregnant mother during the critical periods of sexual development. The in utero effects of finasteride exposure during the period of embryonic and fetal development (gestation days 20-100) were evaluated in the rhesus monkey, a species fairly predictive of human development. Intravenous administration of finasteride to pregnant monkeys at doses as high as 800ng/day (at least 60 to 120 times the highest estimated exposure of pregnant women to finasteride from semen of men taking 5mg/day) caused no abnormalities in male fetuses. Still, Merck retains this admonition: 'Women should not handle crushed or broken Propecia tablets when they are pregnant or may be potentially pregnant because of the possibility of absorption of finasteride and the subsequent potential risk to a male fetus. Propecia tablets are coated and will prevent contact with the active ingredient during normal handling, provided that the tablets have not been broken or crushed.' Considering that intravenous administration of finasteride to pregnant experimental animals during the critical periods of sexual development didn't cause birth defects, there is no reason to believe that transdermal absorption of finasteride from handling broken tablets could cause birth defects in the male child. But, since Propecia has not been approved by the FDA for use by women, Merck has nothing to lose by retaining this warning. In fact, it has good p.r. value. So, can finasteride cause birth defects? Yes, there is a theoretical possibility that it can, but the probability is close to nil, when finasteride is taken in the recommended dosages. Since Propecia was approved by the FDA on 22 December 1997 and Proscar on 28 August 1996, millions of doses of finasteride have been taken and there has not been a single case report of a birth defect. Now that's reassuring information. Richard Lee, M.D. Andersson, S.; Berman, D. M.; Jenkins, E. P.; Russell, D. W.: Deletion of steroid 5-alpha-reductase 2 gene in male pseudohermaphroditism. Nature 354: 159-161, 1991 Greene, S. A.; Symes, E.; Brook, C. G. D.: 5-Alpha-reductase deficiency causing male pseudohermaphroditism. Arch. Dis. Child. 53: 751-753, 1978 Imperato-McGinley, J.; Gautier, T.: Inherited 5-alpha-reductase deficiency in man. Trends Genet. 2: 130-133, 1986 Moore, KL and Persaud, TVN: Before We Are Born-Essentials of Embryology and Birth Defects; 6th Edition, Saunders 2003 New England J of Med: 1994, Jan 13; 330 (2) 120-5 Physicians Desk Reference, 58th Edition, 2004, pp. 2172-2178 Thigpen, A. E.; Davis, D. L.; Milatovich, A.; Mendonca, B. B.; Imperato-McGinley, J.; Griffin, J. E.; Francke, U.; Wilson, J. D.; Russell, D. W.: The molecular genetics of steroid 5-alpha-reductase 2 deficiency. J. Clin. Invest. 90: 799-809, 1992 http://encarta.msn.com/encyclo...exuality.html#endads http://science.howstuffworks.c...an-reproduction5.htm Sex-organ development is determined by the third month of development. http://www.people.virginia.edu/~rjh9u/sexdev.html http://www.lindasy.com/cgi-loc...dec01.html?E+scstore
  6. I also bought Saw palmetto in the past but without significant results. Big 3 are the best conbination to combat hairloss. Finasteride (also buy from 4rx), minoxidil and Nizoral Shampoo. I think the rest is a waste of money
  7. I think miguel72 did not used the right words... We can never say the pills are 100% legit. From 4RX or from any other online pharmacy. My experience with 4RX has been very good for the last years. In the past I used to buy original Propecia. Results have been the same with generic finasteride from 4rx with lower cost... If I have more money I would buy original Propecia from a local pharmacy and pay 80 USD for just 28 pills...
  8. Marvin I have also bought from QualityRx in the past and never had any problem. Now I buy from 4rx. No problems too
  9. I also buy from 4rx for some years. Good results. Also use minox and nizoral
  10. Peter88

    ..

    Yomommyz You should use Minoxidil 5% or with hogher minoxidil concentrations. The combination with Propecia is very good. There is nothing better against hairloss. BIG 3: Propecia Minoxidil (5% up to 15%) Nizoral (1% or 2%)
  11. I have bought from quality-rx for some time and never had problems. www.quality-rx.com/prescriptions/proscar/?fid=5144
  12. Peter88

    ..

    Original Propecia 6 years. Generic 3 years. Good results (thicker hair, no hairloss) but also use minoxidil 5% and nizoral shampoo. No side effects
  13. I buy from 4rx for a long time. Sometimes finasteride comes from Genpharma and sometimes from Cipla. Same results. In the past I used to take original Propecia and the results were not better. So I switch to generic finasteride and the results have been the same with very low cost
  14. If you want normal minoxidil you should buy in a pharmacy. If you want minoxidil solutions with azelaic acid, retinoic acid, or others, you should see www.minoxidil.com
  15. My minoxidil solution, made on local pharmacy, has both ingredients: Propylene Glycol and Glycerin
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