sansi

Evidence so far shows that it is very likely verteporfin will work on a fresh wound no matter if there was a scar before or not. But of course its better to have with HT, as a scar revision will be another surgery, another recovery period, extra money and risks.

I think this case didn't get proper attention. This guy healed scarless after burn injury with verteporfin. https://www.realself.com/review/scarless-after-verteporfin-injected-scar-revision#media-entry-1374536-video-76612

So is it correct to calculate per wound cm2 not per total area ? I guess that's tricky with FUE, in case of linear scar you have an area that is all wound.

Is it 80 mg (200x0.4) ? How to calculate ? Dr. Bloxham's 15mg vial was enough for 3 patients.

@Fox243 can you explain calculation ? How is 10mg enough for 200 cm2 ?

Another win for verteporfin https://www.realself.com/review/scarless-after-verteporfin-injected-scar-revision

Can you explain the math with cm2 and mg ?

Did they agree to send a visudyne ?

There is a guy with a lot of scars, actually he was the first to use verteporfin for scar revision in 2021. He sourced verteporfin and found a doctor to excise some of his scars and inject verteporfin. This was not a proper medical trial as doctor just cared about money and followed instructions by this guy. Recently he updated his cheek burn results and it is scarless . The skin is flat, color is the same as the surrounding area and hair is growing from the burn area. This one is an older comment from this thread

Definitely needs more time for regeneration. The guy who had a burn on his cheek showed his 2 year results and it is scarless. We are getting more and more evidence lately that verteporfin is effective. We just need more doctors and trials.

Hope Dr. Bloxham's updates will confirm this and there will be FUE revision trials. It should be much easier than full FUE, just divide donor area into few parts, try different wounding techniques and inject verteporfin. Even a small trial can be very useful .

https://radiohealthjournal.org/advances-eliminate-scarring/ - This person lives a long time. Some people have many scars. So this would not only be an injection of Verteporfin when the surgeon is closing the incision at the end of the operation, but now you can say, oh, what about all those other scars that have existed for a long time? So one could imagine lidocaine cream being put on the scar, or injection of lidocaine, come back in about 20 minutes and the surgeon excises the scar under local anesthesia in the office, and then injects Verteporfin and the closure, and then it's closed. So there's many, many, many millions of existing scars that could be revised. https://doctrc.org/wp-content/uploads/2023/05/Cleft-Lip-Revision-Drug-Longaker.pdf -Once we have secured FDA approval for Verteporfin in CL/P scar revision, we intend to pursue the use of Verteporfin in adult and pediatric scarring (research already supports this application.) https://www.nytimes.com/2021/04/22/health/surgery-scar.html- His imagination soared. He might be able to prevent scars with a few quick injections of verteporfin. And there was no reason to think he couldn’t go even farther. A patient who had a disabling and disfiguring scar could go to a surgeon who could dab the scar with lidocaine to numb the skin, cut open the scar, inject verteporfin around the edges, and close the wound. Would it reheal without the scar? “That could change their lives,” Dr. Longaker said.

Doctor Barghouthi mentioned once that scars usually get smaller. So if you made 0.9mm wound the scar will be 0.7-0.8mm. Scars also are not as deep as wounds, so maybe not going deep will produce better healing. On the other hand if you don't go deep enough and some scar tissue remains, it may block hair regrowth. Stanford doctors were confident that if you revise old scars, the mechanism of healing would be the same, so if verteporfin can completely heal skin when being injected on fresh wound, it can heal also previously scarred skin. But there are variables that need to be tested, that's why we also need FUE scars revision trials.

This is very good idea. Will definitely spread the word.

It's doable of course but not as straightforward as linear scar revision. When they take out hair follicles they do it under certain angle that matches hair growth direction. So the scar beneath the skin will form with the same angle. Also you don't want to remove extra healthy tissue with bigger punch and with smaller punch you risk to leave there some scarred tissue. You don't know the depth of the scar etc. With this said I believe these are variables that good surgeon will be able to work on.

There are many like you. I think it will be even more demanded. In Bloxham's trials old scars revision seemed to show even better response that virgin skin, 3 month update will give us better info. If doctors find good way of re-punching FUE scars, it will theoretically start healing as virgin tissue.

For new surgeries definitely vert should be used immediately, no reason to go another scar excision procedure. But there are thousands scarred heads from older surgeries.

Would do awesome to have a patient who would share his results. Thank You !

Do you do it with verteporfin ?

Wow Thank you ! Do you think it is as safe and effective as visidyne ?

This is Talbott's. https://stacks.stanford.edu/file/druid:rp239gf7751/Talbott HE Dissertation-augmented.pdf

Thank you. Maybe you should add and emphasize also Maschrak and Talbott papers. They provide very good details about Red Duroc Pig and human Xenograft skin trials. Also does vert cost $200 ? Isn't it like $1800 ?

Many doctors work in comfort and earn bunch of money so the last thing they will want is experimenting with unknown drug.They will join only if it becomes widespread and competitive. We need to find innovative doctors like Doctor Bs or some novice/not famous Doctors who are yet to enter market and don't have much clients. Maybe organizing all the evidence in one space like photos, videos, articles would be helpful to share it with doctors.

That's why I think it's worth to contact him, he makes great video updates, but that requires time. We're close to month 4 but have update only for month 1. I would totally understand if he wants to keep the format and not publish anything before his video updates, but if we had photos/videos from month 4, combine it with Dr. Barghouthis photos, Mascharak and Talbott papers, we would have pretty solid evidence to persuade doctors.

@Fox243 do you have contact with Dr. Bloxham ? By the end of this week it will be 4 months since the trial, linear scar healing can potentially engage much broader audience of plastic surgeons.