Fox243

Because it’s his trial, I would rather wait till he feels comfortable sharing whatever he wants publicly. I have been getting lots of DMs about vert and it’s been a bit overwhelming so I am going to be off the site for a few weeks. I will return after the holidays.

Bro you don’t need to pay money to read these articles. All students get these articles for free. Better for you to donate this money to trials.

kinda... I have it for pigs, which may not apply for humans. Here it is: All animal work was conducted in accordance with APLAC protocol 33742. Full-thickness excisional wounds (2cm x 5cm) were produced on the dorsal skin of 12-week-old red Duroc pigs. Wounds were excised in an elongated hexagon shape such that tension was comparable across their length. PBS (control; 4-6 wounds/pig) and verteporfin (2-8 mg/mL in PBS; 4-6 wounds/pig) were then injected into wounds. Nine injections (100 μL each) were performed per wound: three into the exposed dermis of the left side of the wound; three into the right side of the wound; and three into the base of the wound. Control and treatment wound sites were randomly assigned along the medial/lateral and cranial/caudal aspects to avoid confounding anatomic factors. Given the observed effect size in our first experimental pig and a power analysis, nine wounds per treatment group was deemed sufficient to adequately assess statistical significance. Wounds were primarily repaired with 3-0 Vicryl deep dermal sutures, 3-0 Monocryl running subcuticular sutures, and surgical tape (Steri-Strips). Adhesive wound dressings (Primapore) were applied and changed every 2-3 days for two weeks, then weekly until wounds were fully healed. Wounds were photographed weekly for later scoring on scar visual analog scale (VAS). Cutometer measurements were taken to measure stiffness of normal skin and scars at 8, 10, 12, 14, and 16-weeks post-wounding. Animals were euthanized at 16 weeks post-wounding, and wound tissue divided for analyses as described below. I also have dr. barghouthi's and dr. bloxham's protocols, but I'm not sure if they would like it shared on the web, so if anybody has a surgeon who has actually shown interest, I can DM it to them. Just let me know.

I had but forgot to add it to the literature in the vert doc. Just added now.

Yes, I think there will be enough evidence for standard FUE with plain verteporfin, which is why I want to test combining it with other compounds.

The 15k is being used for the trial. Trials and transplants are expensive. You don’t need a cost breakdown because 15k is so reasonable – at a high level imagine a graft is $5, Verteporfin itself costs $1k, and paying for a patients and doctors time for several follow up visits can easily reach 15k. The point to fund an additional trial is so we see if Verteporfin works alone in the first one and concurrently test out other safe drugs. Cancer drugs makes it sound worse than it is when these drugs are completely benign if you do research, as I have spending hours studying these. Why stifle the scientific progress being made if now is a time for innovation?

Just thinking out loud here: I want to fund one more HT trial with dr barghouthi in which we test two extremely promising FDA compounds that should work in conjunction with veteporfin: imiquimod and vemurafenib, both of which have been fda approved for decades as well. I was thinking either we do a normal fundraiser for around $10k, or if 5 people are willing to each donate $2k, I can talk to Dr. Barghouthi and we can guarantee a priority HT with verteporfin whenever you want at the normal HT rate. If you truly believe in verteporfin, I think this could be a good deal as doctors who have practice with verteporfin will have years long wait lists and the price will significantly increase. Thoughts? Would anybody be willing to deposit 2k to Dr. Barghouthi for what I proposed -- if so, comment below.

Couple reasons: 1) hairdao is a business and hairdao unfortunately cannot make much money for Verteporfin. Because I am a core member, I was able to persuade the others it would be good for PR 2) some people don’t want to get a transplant done and hence topical thyroid could be better

Yes but hoping to market it in 6 months or so if the trials are successful.

We don’t know about anything for Dr Bloxham future plans but he could hopefully use it for his past 3 patients.

It’s a growth stimulant – topical thyroid.

HairDAO is an organization that has raised around 3 million dollars and our goal is to cure hair loss. We’ve done a bunch so far such as create a new treatment (that we are putting through trials in the next 6 months), fund various hair related projects, etc. I’m one of the core members of HairDAO. Happy to answer any questions.

nothing

No 16th isn’t the trial date – it’ll hopefully be sometime in December but really depends on how long for the trichoscope to ship

december 16th

Good luck and feel free to ask me/us any questions.

Here's the doc: https://docs.google.com/document/d/1s3JkF9woMIebkXbpE_UxrjBfNy9i7AuBclDqn9HGrAo/edit

I only allow others to comment and only I have the ability to actually implement their comments

It shouldn’t be locked, is it?

Unfortunately, I reached out again and it seems like he is no longer interested because he thinks running a trial in this fashion is too risky.

If you could find reliable providers to source to him, that would be the greatest help.

It’s quite hard to source Verteporfin in brazil so been having trouble there.

🐐

You should reach out to them. I’m happy to onboard them.

Hey, I wouldn't say that. Melvin has been so helpful to our efforts and I'm gracious for all the work he's done so far.