Swimmy
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It seems some of you are jumping the gun on this real early.
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High levels of DHT increase body hair.
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There's nothing wrong with the site. Its people voicing their experiences on Propecia on the forums. It also contains doctors blogs voicing their opinions and what they have seen from the use of Propecia with their patients.
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Found US distributor for this product. No more jumping through loops to get it.
$90 dollars at the site
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So once the hair sheds, does that mean its dead? (Dead follicles) and your saying that because the hair comb runns off double A batteries it isnt strong enough?
No..The laser diodes in it simply aren't that strong nor enough of them.
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I'm sorry OP but you got ripped off big time. You could have gotten that all done at the fraction of the price.
Someone I know can make POWERFUL effective laser helmets for far less. Just as good if not better than the clinic ones..And is a one time purchase. The laser comb is also a ripoff. Made of cheap plastic and isn't powerful enough to do anything. Lasers are effective but they have to be strong enough.
As for cleaning your follicles and hair there are also cheaper ways for that to.
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JJ said enough. So I don't need to say anything..
If you continue to take propecia later on it might be a good idea to take DIM with it. That will help deal with excess estrogen.
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A lot of what you're saying is either anecdotal, unproven, or purely an opinion. I'm not going to bother sorting out what is what other than to state the following.
A vegan diet properly planned (which I carefully stated) IS healthy. The key is properly planned. It tends to have more fiber, phytochemicals, and antioxidants. There's a strong correlation between those things and wellness.
A human being in 2010 does not "need" meat. A properly planned vegan diet can provide everything a person needs to be healthy (except for vitamin B12, which is readily provided in a lot of fortified foods and in multivitamins) without dietary supplements. This isn't even a point of contention between most nutritionists as long as measures are taken to ensure the vegan diet is balanced and planned to ensure for enough amino acids.
I'm not gonna get into all of it. But its asinine if you actually think vegan diets are 100% healthy.
But like I said for a vegan diet to work you need to supplement ALOT.
Low in omegas 3s, Iron, L-Taurine, Zinc, B12. It can also lead to a copper-zinc imbalance .
Its extremely unhealthy for pregnant women and developing Children. It has its benefit. But it cant completely replace meat let alone achieve the satiety that meat has on people.
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Excellent! That is very exciting news. Now, can a HT surgeon implant new hairs around these ones after they've grown into real hair, assuming I get decent growth but not quite the density I would like? Thanks so much for your help in this!
You should order some Juveline and terminals 1. I'm not on minox or propecia but that stuff alone is causing all kinds of growth in the front for me. They may help boost those vellus hairs into terminals.
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Hello fellow sufferers ;-).
I was using Propecia for 6 years (I'm 32 y/o)with great success : the hair loss halted almost totally. No gain was seemed but since I still had quite a lot of hair I didn't mind. No side effects eather.
About 4 month ago, I started to lose hair like crazy, much more than before starting Propecia treatment and now I have almost visible scalp (diffused thinning) , 5 month only after heaving almost full head of hair.
Do you think Propecia stopped working or rather I developed some kind of tolerance to it ? Maybe DHT levels are to high ?
Did anyone have similar experience.
I now had to add Rogaine (foam ) to my regiment and each day the condition is worsen.
I think I'll shave my head because my hair looks terrible.
What do you think, will it ever stop or not ?
Is it possible to grow back some of what's been lost ?
Propecia with prolong use loses its effectiveness or reduced as one gets older. But not in all cases. It varies.
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You don't agree with it? My taste buds don't agree with it, but a well-planned vegan diet with tons of fruits & vegetables, whole grains and legumes for good health is hard to argue with. Of course exercise has to be thrown into the equation, but diet is at least 50% of it.
A whole vegan diet isn't healthy...You need meat unless you are planning to supplement what you are not getting in that area. If you are suffering from MPB then you should absolutely be avoiding grains such as wheat and legumes.
Fruit is overrated. Unless your ancestry regularly ate it. In other words it depends on your metabolic type if you should be eating fruit..Regardless it should be eaten in moderation. Not a whole bunch. But if you eat fruit eat it with a fiber-rich raw vegetable to offset the rise in bloodugar.
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You should try TRX2 when it comes out in place of Oral Minox. It should have a similar effect. Except that the product is specifically designed for hair. Then maybe add Topical minox and track your results!
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Thought this would be informative as well
1. Minoxidil2. Finasteride
3. Ketaconazole
How do these medications work?
1. Minoxidil, This one works by saturating the scalp till it reaches the bloodstream. Originally treated for High Blood Pressure, many users of the product found that they would grow more hair, or re-grow hair. Once in the bloodstream, it dilates one of the potassium channels, and releases more blood and nutrients through the potassium channel which plays a major role in Hair growth.
(M.P.B. sufferers on average have 2% Blood flow in the scalp, as Non-M.P.B. Sufferers have 10%...)
Minoxidil, chemically is “potassium channel agonist.” Derived from the chemical structure of Nitric oxide (NO), a blood vessel dilator, is a nitric oxide agonist, Minoxidil may also act via release of Guanylate cyclase, an enzyme connected to vasodilation.
Minoxidil tricks the body into thinking it's preforming it's proper duty in ridding your blood system of LDL Cholesterol, Plague, Free-radicals etc..., since the body is receiving these compounds from an outside source, production lessons and becomes limited, hence, those who start rogaine then stop later, experience more shedding, and further hair loss. When the body is tricked this way, it cuts back on natural production and flushing of (NO).
2. Finasteride, This one targets the health of the prostate, changing it's hormonal activity, Originally tested for B.P.H., One of the side effects was hair retention and a lessened of shedding. Finasteride inhibits expression of the enzyme, 5-alpha reductase, which regulates production of dihydrotestosterone (DHT), through treating the enlarged prostate.
(Imbalanced hormone activity is most prevalent in the U.S., and is common among hair loss sufferers).
Finasteride halts production of this enzyme (expression), preventing it to be catalyzed by Testosterone. Though proven effective like rogaine, this should be considered only by older men 40+, Since younger men may develop semi-enlarged prostate during their 20-30's, and can recover naturally.
3. Ketaconazle, Ketoconazole inhibits synthesis of adrenal corticosteroids. Androgenic alopecia has a multi-factorial pathogenesis with an inflammatory reaction caused by a Malassezia fungal infection, Ketaconazole is therapeutic by reducing inflammation through its anti-inflammatory properties and by clearing the adjacent fungal infection.
Ketoconazole shampoo in the treatment of androgenetic alopecia is primarily a function of dihydrotestosterone (DHT) pathway disruption rather than an anti-inflammatory effect. The development of androgenetic alopecia in genetically susceptible individuals has been linked to an overproduction of 5 -reductase and an over expression of androgen receptor, and in rat studies, Ketoconazole has been seen to cause 5 -reductase inhibition.
Additionally, in humans Ketoconazole has also been shown to inhibit the binding of 5 -reductase to sex hormone globulins. All these clinical studies therefore suggest that Ketoconazole may inhibit the production of DHT just like Finasteride. In fact, the effect of Ketoconazole may be two fold, as it has been shown additionally to bind to human androgen receptor.
(Inflammation is a major problem among MPB sufferers, causing itchiness and heat, whilst choking the hair follicles, limiting their blood supply)
Ketaconazole, destroys any fungal activity at the same time releasing inflammation, it targets micro-flora in it's behavior, changing it's actions in relevance to hair.
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Now that we have an idea on what these medicines do, it's time we took a look the correlated diseases, which onset MPB, through 3 main functions;
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Atherosclerosis:
Atherosclerosis is a slow disease in which your arteries become clogged and hardened. Fat, cholesterol, calcium, and other substances form plaque, which builds up in arteries. Hard plaque narrows the passage that blood flows through. That causes arteries to become hard and inflexible (atherosclerosis is also known as hardening of the arteries). It leads to cardiovascular disease, which is the leading cause of death in people over 45. Soft plaque is more likely to break free from the artery wall and cause a blood clot, which can block blood flow to vital organs.
The effects of atherosclerosis differ depending upon which arteries in the body narrow and become clogged with plaque. If the arteries that bring oxygen-rich blood to your heart are affected, you may have coronary artery disease, chest pain, or a heart attack. If the arteries to your brain are affected, you may have a transient ischemic attack (TIA) or a stroke. If the arteries in your arms or legs are affected, you may develop peripheral artery disease. You may also develop a bulge in the artery wall (aneurysm).
This is what Minoxidil mainly assists with, Minoxidil's (NO) like behavior and vascilodating effect create a temporary relief from arterial plaque in the scalp.
Atherosclerosis occurs when Fat, cholesterol, calcium and other non-flushed substances don't get neutralized by anti-oxidents. In reality, it is LDL cholesterol and free-radicals which form plaque.
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Prostate Enlargement: Benign Prostatic Hyperplasia
The cause of BPH is not well understood. No definite information on risk factors exists. For centuries, it has been known that BPH occurs mainly in older men and that it doesn't develop in men whose testes were removed before puberty. For this reason, some researchers believe that factors related to aging and the testes may spur the development of BPH.
Throughout their lives, men produce both testosterone, an important male hormone, and small amounts of estrogen, a female hormone. As men age, the amount of active testosterone in the blood decreases, leaving a higher proportion of estrogen. Studies done on animals have suggested that BPH may occur because the higher amount of estrogen within the gland increases the activity of substances that promote cell growth.
Another theory focuses on dihydrotestosterone (DHT), a substance derived from testosterone in the prostate, which may help control its growth. Most animals lose their ability to produce DHT as they age. However, some research has indicated that even with a drop in the blood's testosterone level, older men continue to produce and accumulate high levels of DHT in the prostate. This accumulation of DHT may encourage the growth of cells. Scientists have also noted that men who do not produce DHT do not develop BPH.
Some researchers suggest that BPH may develop as a result of “instructions” given to cells early in life. According to this theory, BPH occurs because cells in one section of the gland follow these instructions and “reawaken” later in life. These “reawakened” cells then deliver signals to other cells in the gland, instructing them to grow or making them more sensitive to hormones that influence growth.
This is what Finasteride mainly assists with, Through halting the 5-alpha enzyme from being (expressed) properly , thus, there is no catalyst for tesosterone to become DHT. This is a very dangerous drug, petitioned to be removed, it is now banned in Canada, with a pending class action law suit, (which I'm sure propecia would love to settle our of court), and numerous warnings in the UK. I wouldn't be surprised if they banned it as well.
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Diabetes:
More and more research pinpoints inflammation as a root cause of type 2 diabetes. Type 2 diabetes generally results from the combination of impaired beta cell function and insulin resistance acting on susceptible genes. Originally scientists correlated inflammation to obesity to diabetes, but now, it seems that inflammation even without obesity is the likely culprit. Research by scientists at the University of California, San Diego, and Switzerland's University of Fribourg discovered that inflammation provoked by immune cells called macrophages leads to insulin resistance and then to type 2 diabetes. Their research also showed that obesity without inflammation doesn't result in insulin resistance.
Causes of Diabetes
Diabetes mellitus occurs when the pancreas doesn't make enough or any of the hormone insulin, or when the insulin produced doesn't work effectively. In diabetes, this causes the level of glucose in the blood to be too high.
In Type 1 diabetes the cells in the pancreas that make insulin are destroyed, causing a severe lack of insulin. This is thought to be the result of the body attacking and destroying its own cells in the pancreas - known as an autoimmune reaction.
It's not clear why this happens, but a number of explanations and possible triggers of this reaction have been proposed. These include:
infection with a specific virus or bacteria;
exposure to food-borne chemical toxins; and
exposure as a very young infant to cow's milk
Type 2 diabetes is believed to develop when:
the receptors on cells in the body that normally respond to the action of insulin fail to be stimulated by it - this is known as insulin resistance. In response to this more insulin may be produced, and this over-production exhausts the insulin-manufacturing cells in the pancreas;
there is simply insufficient insulin available; and
the insulin that is available may be abnormal and therefore doesn't work properly.
The following risk factors increase the chances of someone developing Type 2 diabetes:
Increasing age, obesity, and physical inactivity.
This is what Ketaconazole mainly assists with, through destroying inflammation, and the fungi in it's prone moist and warm enviorment, healing becomes easier. By 'cleaning' the micro-flora in the scalp, it lets the hair 'breathe' and recieve proper nourishment.
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At this point, we now understand how the medicines work, the correlated diseases (being the precursors for needing to use the medicine to help w/ MPB)
Now it gets more important, as we observe the side-effects of "The Big Three", and how they begin to obstruct and potentially worsen these conditions;
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1. Minoxidil eases symptoms of arterial plaque through entering the bloodstream, although, once in the blood stream it must flow through the heart, (the heart is what suffers in atherosclerosis) and creating abnormally low blood pressure, (another problem, further inhibiting blood flow), affects the blood and could lead to palpitations. The sensation is akin to extreme tiredness. This will only stress the heart more. Due to it's unnatural chemical compound, the heart tries desperately to rid it by working harder to push it to the next organ in order to flush it (The 'water' system) or Kidney and bladder. this results in a heart over-worked with no real excersize, abnormally low blood pressure, and possibly further strain to the Lungs (due to increased oxygen intake to help the heart with it's duties in moving the blood toxin out).
This may further the onset of atherosclerosis, blood toxicity, heart failure, heart attack and stroke.
2. Finasteride eases the prostate enlargement, which is found in most men, and even in young men (although young men do not need finasteride at their age). After being processed by the liver, Finasteride makes it's way to the 'water' system, where it moves into the prostate and prevents an important natural enzyme from being (expressed) properly, through the unnatural down regulation of the 5-alpha reductase. This in turn effects the reproductive organs through not getting it's proper compounds to create healthy semen, thus, impotence, erectile dysfunction, decreased libido (sex drive), abnormal ejaculation, including decreased ejaculate amount. The real problem here is it's estrogen like factor, promoting poorer quality semen, which would naturally go to the prostate to regulate it, and in turn the prostate re-regulating the sexual center back. This then stresses the Kidneys, and hurts the adrenal glands. Besides it limiting your extremely important testosterone producer, and your organisms natural elixir, the liver can become strained from dealing with this chemical compund.
This may further the hormonal imbalance already seen in BPH sufferers, resulting in Infertility, Low T levels, High E levels, Liver toxicity and numerous problems in the reproductive organs. Long term may prove problems for the brain as well.
3. Ketaconazole relieves inflammation and wipes out all natural moisture (being a chemical anti-fungal compound) It deals with the micro-floras activities when applied to the scalp, and dries everything out (so no fungi can survive) through attacking white blood cells causing the inflammation. Since it dries out the skin so bad, the air system (lungs) can be affected, but really what ketaconazole effects most is the stomach through attacking the micro-flora, (the micro-flora are connection points to the flora in your stomach) Hence the stomach may revolt when it detects the medication, seeing it as an outside intruder, harming the micro-flora, in return, pushing more white blood cells, creating more inflammation.
This can hurt natural cooling and lubricant structures in the scalp, and can damage mucous membranes by killing off more than just fungi, this can hurt the breathing system through killing vital micro-components in the skin. Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness and trouble breathing.
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Now we know the potential deadly short-long term effects of "the big three"
Finally, we look towards Natural Medicine, It's "Big three", and how these natural cures are just as effective (if not more), designed to reverse the 3 diseases, and re-gain hair, w/out worrying about life time use or side effects.
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1. Polyphenols - Main sources are pomegranete, dark chocolate 70%+ pure, apples, grapes, green tea and red wine. POM and red wine are highest content.
many evaluations have been done in Japan regarding polyphenols
Apple Polyphenols, a Potent Antioxidant- Health and Medical Information
it was found to be as much as 300% more effective than minoxidil.
Polyphenols act as a vascilodator and an anti-inflammatory, they encourage the release of (NO), in turn naturally dilating blood vessels, cleansing free-radicals (inhibiting the formation of plaque), and lower LDL-cholesterol, through these mechanisms, they body can stop inflammation.
2.Saw palmetto and Lycopene - Main sources of Lycopene are Watermelon, Grapefruit, and Tomatoes.
Harvard study (3) of 47,000 men in 2003 found that men who ate 10 servings per week of tomatos cut their risk of developing aggressive prostate cancer by 50%. Researchers believe this decrease in cancer risk is due to the lycopene in the tomatoes - the pigment that gives tomatoes their red color. We now know that lycopene is the most powerful carotene discovered yet, with 10 times more antioxidant power than beta carotene.
First, Saw palmetto should be taken if you are an older man, Lycopene rich foods for both young and old.
Lycopene when absorbed from the stomach, lycopene is transported in the blood by various lipoproteins and accumulates in the liver, adrenal glands, and testes. Lycopene enters the prostate and with it's anti-oxidizing properties, removes free-radicals, and unneeded hormones, thus, promoting better function.
Saw palmettos main source is beta-sisoterol, which acts similar to Finasteride, although, all the natural catalysts are still connected since it's in it's original form, this is safer, less side effects, and highly effective for the prostate, although should be considered more if mid-life+,
3. Aloe vera - Single source, power plant.
referenced in biblical texts, and torah. The Aloe vera plant was also depicted in 'the garden of eden', lined against the walk ways.
Aloe vera is an extremely powerful anti-inflammatory agent, and can be very nourishing for the stomach, and whole body. Aloe vera works by expelling excess heat and moistening dryness, though what is amazing about Aloe vera is it 'balances' Hot/cold & damp/dry, it acts as a dual effect if your too far one side of the spectrum. Earlier in regards to diabetes, researchers found a major precursor to be inflammation, since the insulin problems are caused by the spleen/pancreas, the stomach sufferers dearly, since the stomach/spleen/pancreas work together as a triad. Aloe vera heals the flora in your stomach, making it able to properly digest, and further assisting the spleen/pancreas in it's actions of producing good insulin. Aloe vera applied to the scalp works similarly in the micro-flora as to relieve the heat, but keeping the needed moisture in, making this extremely beneficial for inflammation and it's hair loss counterpart.
Finally the most important miracle elixer there is, your sperm.
By learning to retain said essence, the body will utilize it and it's properties designed specifically to help you.
First, the retained sperm flows through the prostate signaling no DHT needs to be had, or Estrogen be made, so the prostate goes on, non-enlarged, producing proper healthy enzymes without mutating Testosterone into a quick replacement part for it's sub-normal levels in the body.
Second, The essence enters the stomach region, as the stomach will soon distribute it through out the whole body as an energy source, healing flora, micro-flora, and removing inflammation.
Third, the essence enters the blood for full use, it's healthy T levels re balance the blood, and helps the heart pump strong, all along moving LDL, free-radicals and arterial plaque out!
Finally, the essence is sent to every part of the body to make it stronger, then when it has been used, circles into the kidney, where it can be re used again, with the same effectiveness!
Retention and Circulating this energy is Key.
The Big Three; (Use green tea as base to increase benefits, improve absorption, and attain better results,)
1. Polyphenols - Pomegranette w/Green Tea, Red Wine (French), Apples, Grapes, and Pears
2. Lycopene and/or Saw Palmetto, - Watermelon, Tomato (Juice too)
3. Aloe vera -- Gel topically, Drink unsweetend (2 weeks on, 1 week off)
References:
1. Diabetes, Hair loss, and Aloe Vera - HairlossTalk Support Forums
2. (B.P.H)-Prostate, Hair Loss, Lycopene and Saw Palmetto - HairlossTalk Support Forums
3. Diabetes, Hair loss, and Aloe Vera - HairlossTalk Support Forums
All links provide various articles submitted into PubMed, and are Credible from such source.
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The "Big Three" diseases associated with MPB are: heart disease, prostate cancer and diabetes [1] [2] [3].
Now, when I think of the human heart, I try and choose a hormone associated with a healthy, strong, "athletic" type heart...I instantly think of testosterone; the hormone that keeps you athletically inclined and physically active. Studies have shown that when LDL cholesterol is high, SHBG and testosterone are low [4] [5] [6]. Studies have also shown that vertex balding is a biological marker for atherosclerosis.
When I think of prostate enlargement, I think of estradiol, which is shown to play a huge role in the development of prostate enlargement (along with IGF-1). Estrogen also depresses testosterone and Human Growth Hormone, which can kill your physical endurance, personal confidence and sexual performance! Studies show that a high-fat/ meat-based diet increases estrogen (and possibly DHT) levels [7] [8 [9], contributes to body-fat which decreases insulin sensitivity [10] [11] [12] [13] [14] [15] and also decreases SHBG and IGFBP’s (insulin-like-growth-factor-binding-proteins) [16] [17] [18] [19] which increases free-testosterone and free-IGF-1.
When I think of insulin resistance I think obviously of insulin and insulin-like growth factor 1. When levels of insulin and free-IGF-1 are high, SHBG and IGFBP’s are low and when that's low your hormones become unbalanced. "Free"IGF-1 has been shown to correlate with vertex balding [20] and studies show that dietary-protein particularly animal-protein stimulates free-IGF-1 [19] [21] [22].
Q. "Well, how do I "control" these hormones?"
A. "By avoiding the risks and causes of the three diseases, which are atherosclerosis, insulin resistance, and prostate enlargement.”
Dr. Neal Barnard, Dr. Caldwell Esselstyn and Dr. Dean Ornish have reversed both heart disease and diabetes using a low-fat/high-fiber carbohydrate based vegan diet. And Dr. Neal Barnard has shown that dairy consumption increases prostate enlargement.
[1] Association of benign prostatic hyperplasia with male pattern baldness.
[2] Male pattern baldness and coronary heart disease: the Physicians' Health Study.
[3] Androgenetic alopecia and insulin resistance in young men.
[4] Relationship between Serum Levels of Sex Hormones and Progression of Subclinical Atherosclerosis in Postmenopausal Women.
[5] Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS.
[6] Interrelations between sex hormone-binding globulin (SHBG), plasma lipoproteins and cardiovascular risk.
[7] Effect of a low-fat diet on hormone levels in women with cystic breast disease.
[8] Effect of low-fat diet on female sex hormone levels.
[9] Effect of diet on the plasma levels, metabolism and excretion of estrogens.
[10] Diet and obesity.
[11] High-fat diet, muscular lipotoxicity and insulin resistance.
[12] Low-saturated fat dietary counseling starting in infancy improves insulin sensitivity in 9-year-old healthy children.
[13] Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women.
[14] Dietary fat, insulin sensitivity and the metabolic syndrome.
[15] Vegetarian and vegan diets in type 2 diabetes management.
[16] Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations.
[17] Determinants of circulating insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations in a cohort of Singapore men and women.
[18] The influence of dietary intake on the insulin–like growth factor (IGF) system across three ethnic groups: a population–based study.
[19] The associations of diet with serum insulin–like growth factor I and its main binding proteins in 292 women meat–eaters, vegetarians, and vegans.
[20] Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3.
[21] Relationship of Dietary Protein and Soy Isoflavones to Serum IGF-1 and IGF Binding Proteins in the Prostate Cancer Lifestyle Trial.
[22] Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.
Informative. But I don't agree with a vegan diet.
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I've been getting a ton of zits all over my the parts of my scalp I've been using renokin on. Hopefully they're ingrown hairs or something. I still believe that hair is filling in in the front, not positive though.
looks like they updated the renokin site a little (probably with the money they charged me for 2 bottles) and it says that "consecutive treatment is necessary to achieve efficacy up to the expectation" so I assume that means use it until you have a bunch of hair than you dont need to use it anymore.
zits are a good sign
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Apparently in conjunction with minox there is increased effectiveness
SCIENCE BEHIND TRX2™ MOLECULAR HAIR GROWTH SUPPLEMENTThe recent discovery that potassium ion channels exist within the dermal papilla cells of human hair follicles provided a novel therapeutic target for researchers. Potassium ion channels have been implicated in a vast array of diseases ranging from Hepatitis C to Diabetes. These small pore-forming protein structures control the transport of potassium ions across the hair follicle’s cell membranes and are essential for maintaining the follicle’s full biological activity and function. TRX2 scientists have demonstrated that as people experience hair loss the function of potassium channels within hair follicles diminishes. The effect is impaired membrane potential and interrupted ion transportation across the hair follicle’s cellular membranes – resulting in shrinking follicles and thinning hair.
Based on this research, TRX2 devised an elegant solution for stimulating hair growth on a molecular level: The stimulation of Potassium ion channels within hair follicles.
TRX2™ Molecular Hair Growth Supplement consists of natural substances that our body normally manufactures at sufficient levels in healthy hair, but at insufficient quantities as we experience hair loss. TRX2™ Molecular Hair Growth Supplement is a patent pending composition of normal metabolites that has been shown in laboratory experiments to reduce hair loss and reactivate the growth of hair follicles by:
1. Maintaining the membrane potential of hair follicles
2. Stimulating the de novo synthesis of potassium channels
3. Restoring potassium channel activity & functionality
4. Hyperpolarizing hair follicles
- TRX2™ promotes the hair follicles health and growth on a molecular level.
Boosting Energy Levels in Hair Follicles
In 2007
Foitzik et al. demonstrated that L-carnitine-L-tartrate promotes human hair growth; suggesting that L-carnitine stimulates scalp hair growth by up regulation of proliferation and down-regulation of apoptosis in follicular cells. TRX2™ products are the first to use Potassium and L-carnitine as part of their active ingredients for treating hair loss.Research shows that L-carnitine stimulates hair growth by increasing the energy supply to the massively proliferating and insatiable anagen hair matrix – energy that is also required for the full biological activity of potassium channels in hair follicles.
Maintaining The Cell Membrane Potential of Hair Follicles
The membrane potential is the result of differing voltage between the inner and outer surfaces of a cell’s membrane. This process requires energy-driven potassium channels to move charge against a gradient. The
dermal papilla cells of a healthy hair follicle (one containing sufficient potassium channels) have maximum membrane potential, sustaining the highest level of biological activity. However, as we experience hair loss, the membrane potential of these dermal papilla cells is diminished – a result of the impaired functionality of potassium channels within the hair follicle.TRX2™ contains a compound that stimulates the synthesis of cardiolipin, a key component of the plasma membrane of dermal papilla cells in hair follicles. Cardiolipin plays a crucial role in maintaining the potential and integrity of hair follicle cell membranes. In short, TRX2™ provides the ideal lipid environment for potassium channels to flourish and function at peak efficiency.
Stimulating de novo Synthesis of Potassium Channels in Hair Follicles
The specific potassium channel found in human hair follicles has three major amino acid components: L-Leucine, Isoleucine and Valine (often referred to as
BCAA).By incorporating these components into our proprietary complex, our team has successfully found a way to replenish the membrane potential of hair cells and stimulate the synthesis of new potassium channels within hair follicles.
Stimulating Potassium Channel Activity & Functionality
Physiologically, the potassium channels of hair follicles are regulated by intracellular levels of nucleotides (e.g. ATP and ADP). Therefore, the electrical activity of a cell’s membrane is linked to its metabolism; a relationship that controls many diverse cellular functions.
The TRX2™ composition contains several sources of ATP. TRX2™ activates the transport of high-energy, food-derived products into the body’s mitochondria, where they are ultimately converted into ATP. This captured energy revitalizes potassium channels and is necessary for the regulation of ion transport across the cellular membranes.
Promotion of Hair Growth by Hyperpolarizing Hair Follicles
The TRX2™ complex, similar to the FDA approved treatment minoxidil
(Rogaine™, Regaine™ or RIUP™), has several properties of known potassium channel openers. By hyperpolarizing the hair follicle’s plasma membranes, TRX2™ increases the size of shrunken follicles – resulting in longer, thicker and significantly more hair over the course of treatment.The proprietary composition contains a natural compound,
nicotinic acid, which is structurally related to minoxidil. In combination with the other TRX2™ compounds, nicotinic acid helps keep potassium channels open over time and supports the growth of healthy follicles.TRX2™when used in combination with minoxidil
Topically applied minoxidil is one of the most widely used treatment options against male and female pattern hair loss. However, the clinical outcome of minoxidil based treatment regimen is often disappointing. In many cases the response rates are limited and efficacy decreases or disappears over time after continued use.
Originally minoxidil was developed as an oral antihypertensive drug, but a frequent side-effect was hair growth. The detailed mechanism of action of minoxidil on hair follicles is unclear. However, known as a potent potassium channel opener, it can be assumed that the drug targets the same tiny protein structures (potassium channels) TRX2™ does. Recent studies reveal that the ability of minoxidil to bind to potassium channels and function as an effective channel opener within human hair follicles varies among patients. This may be because every patient has different genetic susceptibilities.
TRX2™’s potassium channel activating nutrients work well in combination with existing minoxidil based treatment regimens such as Rogaine™ (Regaine™ or RIUP™). Our proprietary TRX2™ Hair Growth Complex has been shown in studies performed to date to boost overall efficacy of minoxidil treatmentandto significantly improve the results even in those patients who have not previously experienced positive responses.
Uncovering the right formula of natural ingredients was a massive undertaking. Our dedicated team of scientists needed to design a variety of new research methods specifically for the purpose of targeting potassium ion channels for hair growth. After trying hundreds of different formulations of micro-nutrients, we centered upon the TRX2™ formula that includes a plethora of unique and powerful ingredients. This approach has allowed our company to succeed where others have failed. Our product works with your body to protect hair cells from damage and degradation. There are no side-effects, no complications and no hassle – just honest, noticeable results.
Listed below are some of the specific beneficial effects observed at the cellular level:
Cellular level
- Increased membrane potential of dermal papilla cells in hair follicles
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De novo synthesis of potassium channels
- Enhanced potassium channel activity & functionality
- Hyperpolarized hair follicles
This product is specifically designed for patients suffering from the early stages of hair loss (Norwood 1-4). Some of the benefits reported by those who regularly take two TRX2™ Molecular Hair Growth tablets per day include:
Visual level
- The cessation of hair loss
- The re-growth of hair follicles – including re-growth in the frontal region and temple area
- Visibly stronger & thicker hair shafts
- TRX2™ promotes the hair follicles health and growth on a molecular level.
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Right when it spoke of potassium channels I knew it would have a similar effect that minox does.
TRX2™ Molecular Hair Growth Complex was developed based on laboratory experiments that turned closed, dysfunctional potassium channels into open, fully activated potassium channels.
The proprietary potassium channel-stimulating complex within TRX2™ contains a patent pending combination of micro-nutrients. Potassium, L-carnitine, BCAA and nicotinic acid work with your body to postpone-hair loss and stimulate the growth of hair follicles on a molecular level
How TRX2™ Molecular Hair Growth Supplement Works
TRX2™ Molecular Hair Growth Supplement acts on potassium channels, small pore-forming protein structures that control the transport of potassium ions across the hair follicle’s cell membrane. Healthy potassium channels are essential for maintaining the hair follicle’s full biological activity. TRX2 scientists have demonstrated that as people experience hair loss the function of potassium channels within hair follicles diminishes. The effect is impaired membrane potential and interrupted ion transportation across the hair follicle’s cellular membranes – resulting in shrinking follicles and thinning hair. Based on this research, TRX2 devised an elegant solution for stimulating hair growth on a molecular level: The stimulation of potassium ion channels within hair follicles. TRX2™ Molecular Hair Growth Supplement facilitates the entry of fuel (amino acids, lipids and regulatory compounds) into the hair follicle and stimulates the production of new potassium channels – postponing hair loss and growing new, healthy hair. For more information on this process, click on Science.
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Not really. The only real cure for Androgenetic Alopecia would be gene therapy. You can grow regrow all the hair you want but you'll still have alopecia
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Home site..But right now it looks like its updating..Trx2 - Science of hair growth
Blog is still up-http://www.trx2.com/blog/
It of course will be a year in January and that's when the product should be out
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This article is from 9 months ago. But relevant
Thomas Whitfield: The Oxford student who plans to make baldness a thing of the pastAn Oxford PhD is developing a new technology that he believes will offer effective hair loss prevention to the masses.
There comes a moment in most men's lives when they have to admit that they are losing their hair. The realisation is painful enough; doing something about it is even worse. The slippery descent into lotions and pills, toup?s and skin grafts fills most with horror. But where there's vanity there's money to be made. Hair loss can also, for some, equal a loss of career prospects and of confidence. Suddenly a solution turns from vanity product into an essential and valuable treatment.
So keep an eye on Thomas Whitfield. The 27-year-old Oxford biochemistry PhD is working on a venture called TRX2 (derived from the Greek word for hair, Trichos. "The two for second – your second generation of hair," he tells me). It promises to make "hair loss a thing of the past". Still in stealth mode as the intellectual property is in the process of being protected, Whitfield plans to have his "product and service" on the market within 12 months. His only guidance is that it is not based on "gene therapy" – an area being explored by several other British start-ups.
The Kilcady-born entrepreneur, who grew up in Germany – his mother is German – said: "Current treatments don't work properly or they are inconvenient or they are simply very, very expensive. We have come up with a solution that's quite easy and much cheaper."
To add to his credibility, he has already founded a successful internet venture called Miomi.com , which plots user-generated personal histories.
Yesterday he flew to the US, where he will spend time at the cutting edge InCube Labs, a medical devices incubator in Silicon Valley. Finally, he still has a full head of light brown hair – it helps him to remain "objective".
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That doesn't look like it needed 5000 grafts worth of work?
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1. oooh woooow , thank you very much swimmy , i understood clearly , but i don't know whether i am having sensitive skin or not ? so i will buy this DMSO 99% ,after using it if i get any irritation then i will switch on to 50 to 70 % ..
thank you swimmy . i will use these things putting all my trust in god , because beyond everything my head will be fine only by god 's grace ,so hope i wil be saved from this itching and balding by god 's grace ... 2. I am being a poor guy i can buy only EMU oil for my thin hair for regrowth swimmy ,
a. but will EMU oil really works in regrowth and thickening hair in front and in crown ?
b. and how long it will take to give a good result of EMU oil swimmy ? ..
thank you waiting for your reply swimmyNot sure on the EMU. Mixed results. Some people respond well. Some don't. Its hit or miss
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Whatever works for you. The DMSO+ lithium orotate will be added to your shampoo and will replace nizoral. You can try and see what works and what doesn't..
thank you very much for your useful information swimmy .
I am going to buy DMSO in gel form , and lithium orotate in powder form . thank you very much dude . take care MAY GOD BLESS YOU MORE AND MORE .
Hey, i'm not sure on the DMSO gel. You'll probably just be better off with the liquid form..never tried the gel. So don't know how that's gonna work. Sometimes the solution can be too high for people with sensitive skin
Per 8 oz bottle
1 tsp of DMSO liquid (99%). If you have sensitive skin use a 50 to 70% solution.
1 & 1/2 teaspoons to 2 teaspoons of crushed Lithium pills (or powder)
Add to your choice of sls free shampoo
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1. now my dear friend Swimmy . i am not much exposed to online buying products , i am so much afraid of the fake sites and hacker , so please help me in giving me the site or url for " Jarrows Curcumin 95 , country life or Now foods resvertral , sls free shampoo ,DMSO liquid and lithium orotate" which you are regularly buying online . so that i will have confident that i am buying the exact product which you have prescribed . I am sorry Swimmy if i am distrubing you much .
Iherb.com. Is a good site. It contains lots of brands. However, you live in India so I'm not sure how international shipping is.
This is where I get the DMSO
Cocoon Nutrition - Scientific Breakthroughs for Radiant Health
Lithium
Beyond A Century, Inc.: Minerals
But again not sure on international shipping
2. my final request swimmy , Actually i am not completely bald before ,but was having less density hair in front and in crown due to genetic like my father . To stop the hair loss i am using finasteride for one and half month ,i can feel that my hair loss is some what stoped and i checked this by shaving my head , now i got hair in all the area without gap , but i can feel that all the hair that are growing in front and in crown area are so thin compare to the hairs in sides and back , so is there any way to make these thin hair in front and crown to grow thicker ? .....
It could take about a year on fin to see regrowth. You could try 5% minoxidil.Other than that there are experimental drugs and topicals out there that MAY give regrowth, who knows, and if you have the extra income. You could also try cheaper solutions like Emu oil.
3. yesterday due to much itching on my scalp, i bought Lobate cream (temovate(dermovate) generic chobetasol propionate) in the medical shop near my house ,i applied that in the morning and i washed my head with nizoral shampoo in evening, now to be honest , there is no itching on my scalp and i slept well yesterday with out any itching , so now shall i continue to apply this lobate cream(temovate(dermovate) generic chobetasol propionate) which i bought ? or shall i switch on to SLS free with DMSO liquid and lithium orotate ? .... thanks in advance swimmy . waiting for your reply
Whatever works for you. The DMSO+ lithium orotate will be added to your shampoo and will replace nizoral. You can try and see what works and what doesn't..
thank you waiting for your reply swimmy
Hair Loss - A Disease of Civilization?
in Open Hair Loss Topics
Posted
There's a forum called immortalhair that touches thoroughly on this topic and has the research to back up these claims..Yes diet plays a big part in MPB if people want to believe it or not on this forum. The perfect diet can eliminate MPB. But that's easier said than done. Our diet can have a major impact on our genetic predisposition to MPB. Foods can increase inflammation, oxidative stress, free radicals, insulin levels, increase dht or estrogen in the body. The right foods can also do the opposite.
I mentioned this before but Japan is the healthiest nation in the world and also experiences the lowest MPB rate.. What is funny is that MPB increased in their country though after WW2 when the western diet was introduced to them.
The western diet is definitely one of the worst things for those vulnerable to MPB..Even cleaning up your diet a little would help.