trx2

[Swimmy]

This article is from 9 months ago. But relevant

 

 

Thomas Whitfield: The Oxford student who plans to make baldness a thing of the past

 

An Oxford PhD is developing a new technology that he believes will offer effective hair loss prevention to the masses.

 

 

There comes a moment in most men's lives when they have to admit that they are losing their hair. The realisation is painful enough; doing something about it is even worse. The slippery descent into lotions and pills, toup?s and skin grafts fills most with horror. But where there's vanity there's money to be made. Hair loss can also, for some, equal a loss of career prospects and of confidence. Suddenly a solution turns from vanity product into an essential and valuable treatment.

 

So keep an eye on Thomas Whitfield. The 27-year-old Oxford biochemistry PhD is working on a venture called TRX2 (derived from the Greek word for hair, Trichos. "The two for second – your second generation of hair," he tells me). It promises to make "hair loss a thing of the past". Still in stealth mode as the intellectual property is in the process of being protected, Whitfield plans to have his "product and service" on the market within 12 months. His only guidance is that it is not based on "gene therapy" – an area being explored by several other British start-ups.

The Kilcady-born entrepreneur, who grew up in Germany – his mother is German – said: "Current treatments don't work properly or they are inconvenient or they are simply very, very expensive. We have come up with a solution that's quite easy and much cheaper."

To add to his credibility, he has already founded a successful internet venture called Miomi.com , which plots user-generated personal histories.

Yesterday he flew to the US, where he will spend time at the cutting edge InCube Labs, a medical devices incubator in Silicon Valley. Finally, he still has a full head of light brown hair – it helps him to remain "objective".

 

 

[Swimmy]

Home site..But right now it looks like its updating..Trx2 - Science of hair growth

 

 

Blog is still up-http://www.trx2.com/blog/

 

 

It of course will be a year in January and that's when the product should be out

[slowjo]

Not too promising when right on their blog they say "There is still no “cure” for Androgenetic Alopecia. Although there are many promising treatments currently in development, it is unlikely that any of these therapies will be able to reach the market before a considerable amount of safety trials have been conducted in a controlled and clinical setting." Translated...we have nothing and are stalling for time.

[Swimmy]

Not really. The only real cure for Androgenetic Alopecia would be gene therapy. You can grow regrow all the hair you want but you'll still have alopecia

[Swimmy]

Right when it spoke of potassium channels I knew it would have a similar effect that minox does.

 

 

TRX2™ Molecular Hair Growth Complex was developed based on laboratory experiments that turned closed, dysfunctional potassium channels into open, fully activated potassium channels.

The proprietary potassium channel-stimulating complex within TRX2™ contains a patent pending combination of micro-nutrients. Potassium, L-carnitine, BCAA and nicotinic acid work with your body to postpone-hair loss and stimulate the growth of hair follicles on a molecular level

 

How TRX2™ Molecular Hair Growth Supplement Works

 

 

TRX2™ Molecular Hair Growth Supplement acts on potassium channels, small pore-forming protein structures that control the transport of potassium ions across the hair follicle’s cell membrane. Healthy potassium channels are essential for maintaining the hair follicle’s full biological activity. TRX2 scientists have demonstrated that as people experience hair loss the function of potassium channels within hair follicles diminishes. The effect is impaired membrane potential and interrupted ion transportation across the hair follicle’s cellular membranes – resulting in shrinking follicles and thinning hair. Based on this research, TRX2 devised an elegant solution for stimulating hair growth on a molecular level: The stimulation of potassium ion channels within hair follicles. TRX2™ Molecular Hair Growth Supplement facilitates the entry of fuel (amino acids, lipids and regulatory compounds) into the hair follicle and stimulates the production of new potassium channels – postponing hair loss and growing new, healthy hair. For more information on this process, click on Science.

Edited October 12, 2010 by Future_HT_Doc
removed outside link

[Swimmy]

Apparently in conjunction with minox there is increased effectiveness

 

 

SCIENCE BEHIND TRX2™ MOLECULAR HAIR GROWTH SUPPLEMENT

 

 

The recent discovery that potassium ion channels exist within the dermal papilla cells of human hair follicles provided a novel therapeutic target for researchers. Potassium ion channels have been implicated in a vast array of diseases ranging from Hepatitis C to Diabetes. These small pore-forming protein structures control the transport of potassium ions across the hair follicle’s cell membranes and are essential for maintaining the follicle’s full biological activity and function. TRX2 scientists have demonstrated that as people experience hair loss the function of potassium channels within hair follicles diminishes. The effect is impaired membrane potential and interrupted ion transportation across the hair follicle’s cellular membranes – resulting in shrinking follicles and thinning hair.

Based on this research, TRX2 devised an elegant solution for stimulating hair growth on a molecular level: The stimulation of Potassium ion channels within hair follicles.

TRX2™ Molecular Hair Growth Supplement consists of natural substances that our body normally manufactures at sufficient levels in healthy hair, but at insufficient quantities as we experience hair loss. TRX2™ Molecular Hair Growth Supplement is a patent pending composition of normal metabolites that has been shown in laboratory experiments to reduce hair loss and reactivate the growth of hair follicles by:

1. Maintaining the membrane potential of hair follicles

2. Stimulating the de novo synthesis of potassium channels

3. Restoring potassium channel activity & functionality

4. Hyperpolarizing hair follicles

 

 

• TRX2™ promotes the hair follicles health and growth on a molecular level.
  

 

 

 

 

 

 

 

 

 

Boosting Energy Levels in Hair Follicles

 

 

In 2007

Foitzik et al. demonstrated that L-carnitine-L-tartrate promotes human hair growth; suggesting that L-carnitine stimulates scalp hair growth by up regulation of proliferation and down-regulation of apoptosis in follicular cells. TRX2™ products are the first to use Potassium and L-carnitine as part of their active ingredients for treating hair loss.

 

 

 

Research shows that L-carnitine stimulates hair growth by increasing the energy supply to the massively proliferating and insatiable anagen hair matrix – energy that is also required for the full biological activity of potassium channels in hair follicles.

 

 

 

 

 

 

Maintaining The Cell Membrane Potential of Hair Follicles

 

 

The membrane potential is the result of differing voltage between the inner and outer surfaces of a cell’s membrane. This process requires energy-driven potassium channels to move charge against a gradient. The

dermal papilla cells of a healthy hair follicle (one containing sufficient potassium channels) have maximum membrane potential, sustaining the highest level of biological activity. However, as we experience hair loss, the membrane potential of these dermal papilla cells is diminished – a result of the impaired functionality of potassium channels within the hair follicle.

 

 

 

TRX2™ contains a compound that stimulates the synthesis of cardiolipin, a key component of the plasma membrane of dermal papilla cells in hair follicles. Cardiolipin plays a crucial role in maintaining the potential and integrity of hair follicle cell membranes. In short, TRX2™ provides the ideal lipid environment for potassium channels to flourish and function at peak efficiency.

 

 

 

 

 

 

Stimulating de novo Synthesis of Potassium Channels in Hair Follicles

 

 

The specific potassium channel found in human hair follicles has three major amino acid components: L-Leucine, Isoleucine and Valine (often referred to as

BCAA).

 

 

 

By incorporating these components into our proprietary complex, our team has successfully found a way to replenish the membrane potential of hair cells and stimulate the synthesis of new potassium channels within hair follicles.

 

 

 

 

 

 

Stimulating Potassium Channel Activity & Functionality

 

 

Physiologically, the potassium channels of hair follicles are regulated by intracellular levels of nucleotides (e.g. ATP and ADP). Therefore, the electrical activity of a cell’s membrane is linked to its metabolism; a relationship that controls many diverse cellular functions.

 

 

 

The TRX2™ composition contains several sources of ATP. TRX2™ activates the transport of high-energy, food-derived products into the body’s mitochondria, where they are ultimately converted into ATP. This captured energy revitalizes potassium channels and is necessary for the regulation of ion transport across the cellular membranes.

 

 

 

 

 

 

 

Promotion of Hair Growth by Hyperpolarizing Hair Follicles

 

 

The TRX2™ complex, similar to the FDA approved treatment minoxidil

(Rogaine™, Regaine™ or RIUP™), has several properties of known potassium channel openers. By hyperpolarizing the hair follicle’s plasma membranes, TRX2™ increases the size of shrunken follicles – resulting in longer, thicker and significantly more hair over the course of treatment.

 

 

 

The proprietary composition contains a natural compound,

nicotinic acid, which is structurally related to minoxidil. In combination with the other TRX2™ compounds, nicotinic acid helps keep potassium channels open over time and supports the growth of healthy follicles.

 

 

 

 

 

 

 

 

 

 

 

TRX2™when used in combination with minoxidil

 

 

 

 

Topically applied minoxidil is one of the most widely used treatment options against male and female pattern hair loss. However, the clinical outcome of minoxidil based treatment regimen is often disappointing. In many cases the response rates are limited and efficacy decreases or disappears over time after continued use.

 

 

 

 

 

 

Originally minoxidil was developed as an oral antihypertensive drug, but a frequent side-effect was hair growth. The detailed mechanism of action of minoxidil on hair follicles is unclear. However, known as a potent potassium channel opener, it can be assumed that the drug targets the same tiny protein structures (potassium channels) TRX2™ does. Recent studies reveal that the ability of minoxidil to bind to potassium channels and function as an effective channel opener within human hair follicles varies among patients. This may be because every patient has different genetic susceptibilities.

 

 

TRX2™’s potassium channel activating nutrients work well in combination with existing minoxidil based treatment regimens such as Rogaine™ (Regaine™ or RIUP™). Our proprietary TRX2™ Hair Growth Complex has been shown in studies performed to date to boost overall efficacy of minoxidil treatmentandto significantly improve the results even in those patients who have not previously experienced positive responses.

 

Uncovering the right formula of natural ingredients was a massive undertaking. Our dedicated team of scientists needed to design a variety of new research methods specifically for the purpose of targeting potassium ion channels for hair growth. After trying hundreds of different formulations of micro-nutrients, we centered upon the TRX2™ formula that includes a plethora of unique and powerful ingredients. This approach has allowed our company to succeed where others have failed. Our product works with your body to protect hair cells from damage and degradation. There are no side-effects, no complications and no hassle – just honest, noticeable results.

Listed below are some of the specific beneficial effects observed at the cellular level:

 

 

Cellular level

 

 

 

1. Increased membrane potential of dermal papilla cells in hair follicles
   
2. De novo synthesis of potassium channels
   
3. Enhanced potassium channel activity & functionality
   
4. Hyperpolarized hair follicles
   

 

 

This product is specifically designed for patients suffering from the early stages of hair loss (Norwood 1-4). Some of the benefits reported by those who regularly take two TRX2™ Molecular Hair Growth tablets per day include:

 

 

Visual level

 

 

 

• The cessation of hair loss
  
• The re-growth of hair follicles – including re-growth in the frontal region and temple area
  
• Visibly stronger & thicker hair shafts