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4 hours ago, Alex11 said:

The official paper for the pig trial is in peer review -stage, and has not been published yet. This is most likely the reason for the confidentiality of some details.

But what is the harm done when the public knows these details?

4 hours ago, Alex11 said:

As far as I know, the dosages used in the Verteporfin studies at Stanford have not been published anywhere. Even in the detailed dissertation by Talbott (https://stacks.stanford.edu/file/druid:rp239gf7751/Talbott HE Dissertation-augmented.pdf), only discussions concerning concentrations (e.g. 2 mg/mL) are being made, with no mentioning of volumes injected (i.e. the dosages).

You wrote: "This means we are very close to the optimal dosage. 0.4mg per cm2 is close to 2mg used for 5cm.". Could you please clarify the source for this claim.

 

 

Maybe I am missing something here, but what is the point of research if the outcomes are being hidden?

2 hours ago, alopeciaphobia said:

True, although in the case of FUT the entire wound is sutured, so we can't assess regrowth potential.

Of course reduced scarring is also a very interesting outcome, but it's not nearly as much of a potential breakthrough as donor regeneration.

According to theory, they should go hand in hand. 

Whether that is the case remains to be seen, but I do think that if we get scarless healing, donor regeneration is a very real possibility.

14 hours ago, alopeciaphobia said:

It's beyond fantastic that we have two full FUE case studies coming up, and that these are with even higher dosages, and an improved injection technique.

 

These should really be able to give us a much better idea of whether HT+verteporfin is or isn't the world's first procedure that can effectively multiply hair follicles.

 

By summertime next year, we may finally have a decent indication of whether this may be the major breakthrough that many of us hoped it would be ever since the first animal study. It's really really cool to be following this. Thank you @DrTBarghouthi.

The Bloxham-trial started over 3 months ago. He estimated that he could probably draw some preliminary conclusions after 3-4 months. He is, like dr. Barghouthi, probably a super busy guy, so it might take him awhile, but I guess he will be reporting about it soon. 

It is unlikely that the whole skin of the patient healed without scars, there is probably some optimization we have to do regarding dosages / application methods etc, but if there is a semblance of scarless skin that would be a very good sign that verteporfin works in humans as well.

Easily the most promising development in hairloss ever. 

2 hours ago, Melvin- Admin said:

This thread is going off the rails. This is a novel approach by a doctor who has nothing to gain but help the community. I’ve been very tolerant, but I won’t be moving forward. If you guys don’t believe in this or the doctor. Don’t post. No one is forcing you to follow. 

The comments have not been respectful. I expect we all show some gratitude and respect to Dr. Barghouthi whose doing his best. After all, he’s a hair transplant surgeon, not a clinical researcher. His priority is and should be his clinic.

Also, stop touting someone else’s donation as a way to demand something.  Dr. Barghouthi doesn’t owe you, me or anyone anything. Each day of surgery he’s missed on this trial, on top of the cost of paying his employees and the Verteporfin. I guarantee, it’s well over what anyone has donated. 

The amount donated was just for the verteporfin right? That means that dr. Barghouthi is still doing everything for free and in his own time. He even leaves money on the table, because all the time he is devoting to this project he can't spend on commercially more attractive options.

It is great that the money has been raised, it should be handled with transparency and great care, but it is not that the doc took it for himself and ghosted the community. 

16 minutes ago, sansi said:

@Melvin- Admin why do you ignore this request ?

If you don't have photos or can't share them for some reasons, please just tell.

You can pause the video on any moment you like and capture the screen.

5 hours ago, sansi said:

So what's the conclusion for the first trial success/failure or something between ?

Last update I could find was in April, was there update after that ?

Thanks

My takeaway from that trial is that it looked like there was substantial regrowth in the Test sites as compared to the Control sites. Especially for the higher dosages.  Following up with that patient would, I think, provide a lot of useful info on its efficacy for hair regeneration. For some reason unknown to me it is just not happening. Maybe the patient is no longer available or so. 

3 hours ago, DrTBarghouthi said:

Hi guys,

I hope you’re all keeping well. I do appreciate the excitement and I equally share that. The trial is going ahead. I know we postponed it because we simply thought we might have some extra input that could help. Nonetheless, I don’t feel there is much need to wait. I will have a ser date to share by this coming week. I just want to clarify that when one date is missed it usually takes longer than desired to come up with a new date to fit in our schedule- as most patients will be usually booked ahead of time. It also has to take into account the availability of the volunteer on that new date etc. I just needed to clarify the reason why we get gaps between each set date. 
This has been a great collaborative effort and we should focus on keeping it as such - both in efforts and in spirit. We’ll get there! 

Again, many thanks for your pioneering!

Regarding extra input for the trial, are you in contact with dr. Bloxham about his experiences? Maybe they come in handy when conducting this one.

Dr. Barghouthi is ready when he is ready. Whether that would be today or in a year, or even later.

We don't have to despair though, the Bloxham-experiment is around the 2 month mark. He said himself that he expects to draw preliminary conclusions after the 3-4 month mark, so that really isn't far off. 

10 hours ago, TV_on_LazerDisk said:

This is exciting. I'm curious how fue megasession recovery is with this

Also wondering how different dosages maybe effect the amount of hair regeneration 

Judging from the video from dr. Bloxham, the application method is also not as straightforward as one might think. Maybe there is some learning curve there as well.

And of course, great news about dr. Pittella also joining the list of doctors experimenting with verteporfin. Credits to Melvin again.

2 hours ago, Melvin- Moderator said:

UPDATE: 

Dr. Longaker canceled the meeting. He was in the clinic assisting a doctor that called out. I asked his secretary for another date, but I haven’t received a response. I will update you guys if and when she responds. 

I think we may have to push forward without his input. But lets hope he reaches out. 

Too bad, but thanks for trying though. 

Could the call maybe be a little bit too much of a commitment? Maybe you can mail him your questions so that he could mail back whenever convenient for him?

On 8/26/2023 at 10:28 PM, blackpink said:

His initial YouTube video was put out on July 21st and he did the procedures around July 11th. So as of now it's only been about a month-ish. One site mentioned that he'd share a lot more data around months 3-4, so I'd expect updates around October-November. I'm also keeping an eye on this for both use cases (scar reduction/healing and hair follicle neogenesis)

If there is a way to contact him it might be useful to ask him about the healing of the skin in his patients. The effect of verteporfin should be that this it is slower, but without scars. After 1,5 month, the skin healing should be about complete under normal circumstances, so if his patients report a slower recovery that could be a sign of the drug working. 

Nothing to get overly excited or pessimistic about, a faster or slower healing process can have other causes too, but i could be an indication.

On 8/23/2023 at 4:56 PM, TV_on_LazerDisk said:

Also has anyone considered hgh or hgh releasing peptides (I know they use this with burn victims to regenerate tissue), or peptides that help with wound regeneration bpc 157, tb500

Let´s first focus on the effect of verteporfin alone and focus on different dosages, application methods etc. According to theory, that should already be enough. 

When enough research is in and this effect is well understood, we can look at other ways to improve efficacy if needed.

3 minutes ago, TV_on_LazerDisk said:

Maybe it depends on suturing, how they close the wound in the video Bloxham says he's more focused on scar reduction. 

He is more focused on evaluating that effect of verteporfin, but according to the theory he laid out himself, they go hand in hand. So either they both happen or they do not.

27 minutes ago, Magic City said:

Does anyone know when we can expect updates from Dr. Bloxham?

I expect them rather soon, scarless recovery takes longer than a normal recovery. So if verteporfin is working, this should be observed quite quickly.

4 hours ago, TV_on_LazerDisk said:

I did, he's focused more on scar reduction. 

I think bargouthi is focusing more on hair regeneration. So I'm really excited about his upcoming fut trials. 

Having two doctors investigating it will def help. 

In theory, you can´t have one without the other though. The theory is that, by deactivating the fibroblasts, the skin recovers normally, so without the scar tissue but with the sweat glands, hair follicles etc. 

Really excited to see his results, as well as for the dr. Barghouthi´s second trial of course.

It is unfortunate that the second trial takes longer than expected to start, of course I would like to see it happening as soon as possible too, but that is just life. Things get in the way, people get sick etc. Let's not dwell on that for too long.

I also think it is reasonable to wait a couple of weeks on the input of dr. Longaker. If he has pointers on the dosage, delivery method or anything else that could influence the results, that would be well worth the waiting time. It would be a shame to start now and find out that the trial could have been better by waiting a bit longer on the information of the doc. 

I would like to mention again that an evaluation of the current status of the original patient seems very valuable to me. Is there any possibility to do a follow-up with him?

17 hours ago, alopeciaphobia said:

I was just pixel-peeping the results so far and I'm getting the impression that some of the conditions may have been mixed up? It looks like two different areas have both marked as 0.4mg T.

In this image here it's the leftmost square (since no excisions are visible to the left) marked as 0.4mg T.

Whereas in the image here it's not the leftmost square (as there is another square of excisions very close to it on the left side) that's marked as 0.4mg T.

A couple of other surrounding features of the scalp also seem not to match up.

 

I believe that the first photo I quoted (with the red marker) is the first square on the photo below, and the second photo I quoted (with the blue vertical line drawn in it) is the third square on the photo below:

If I had to guess, based on having just reviewed all of the photos, the conditions are from left to right: 0.32T, 0.32C, 0.4T, 0.4C, 0.24T, 0.24C, and the first photo I quoted (with the red marker) is the incorrectly marked one and is actually 0.32T.

Is this correct, or am I tripping?

I am not able to tell.

Would, if true, this finding impact the preliminary conclusion about the effectiveness of the doses? 

13 hours ago, tatasabaya said:

Dr. Bloxham just dropped this video:

 

I've been wondering, if Verteporfin is proven to work successfully in humans and the demand grows exponentially, how long would it take for the suppliers to catch up? Is it hard to scale things up?

Great, this guy is actually passionate about the experiment instead of "ok, ok, I'll try it". Also very positive that he is in contact with dr. Barghouthi. 

Is there a date known that he will make his first evaluation? Missed that from the video 

8 hours ago, Dieter987 said:

That is not like hairloss cure #4578. 

It is well known that fetuses do not form scars from injuries. The stanford papers shows a significant scar improvement in pigs and a hair regeneration of 50% with FAK inhibitors. 

If the first tests do not show any relevant results, it means nothing. 

I really hope that verteporfin can improve scars and/or hair regeneration, but it will probably be too weak.

And again, it could not only be used against scarring and hair loss, but possibly also against heart muscle scarring, fibrosis of the lungs, etc.

Please read the full sentence, it says "to an outsider". Most people don't care to get that deep into a hairloss-cure. To them, it is the next flashy thing with supposedly incredible science behind it, just never to be heard of again. 

I personally do have faith in verteporfin, I think the results of the initial trial deserve a follow-up. Happy to see that coming, let's wait and see what they will bring.  

Let´s be honest. At this point, the community still has difficulty in convincing its' own insiders (Mohebi, Rassman, Bisanga etc.) of verteporfin. To an outsider, this is most likely just hair loss "cure" #4578 where the previous 4577 attemps failed. 

Besides that, I don't think the backing of a Musk or Rogan would be necessary or even positive.  There are already trials taking place that will in a rather short term show whether there is potential for further research. In that case, more (reputed) surgeons like those mentioned will be open to trials. If a beneficial effect of verteporfin exists, it will be found thanks to the advocacy of this community (especially Melvin).

Let's say it works to a degree and Rogan promotes it. Many people will want it and with the small supply of verteporfin, prices will skyrocket and actually getting the stuff will be harder.

On 7/14/2023 at 7:34 PM, Melvin- Moderator said:

I’ll message his coordinator. At least if we have a multi-center study, we can know for sure whether it’s something worth pursuing or not. Lack of data doesn’t mean it doesn’t work. 

I know I have mentioned it already several times, but is there a possibility to check the original patient on his current state? If the test sites visually still look much better than the control sites, that would be a nice indication that the treatment works and passes the test of time. It's not scientific in the way people like dr. Mohebi would like to see, but still valuable I guess.  

What do you think about it?

On 7/4/2023 at 9:36 PM, Fego said:

Any update about the photo of patient from Dr talab. We almost close to year? 

That is what I would like to know as well!

This thread is close to celebriting its' anniversary. I am super curious whether the (visual) gains that the original patient seemed to have made are still there. Are there follow-ups planned with him?

On 6/11/2023 at 12:05 AM, Jonathan said:

4 hours ago, TheGreatPretender said:

I have spoken with Dr De Freitas during my intervention and explained him the current trials and reesearch, also mentioned that loads of the big names within the hair transplant field took a keen interest on it.

He said he was gonna have a look and told him to get in touch with Melvin to get further information so hopefully he can also start doing some trials. 

The more names we can get to try this out the better. At least I have played my part. 

Yes all of it! Especially dosages, wether it’s FUE or FUT, and yes results as well.

Great work!

A while ago, a backer donated around 15.000 to fund a trial. Has that trial already begun?