Senior Member Mountinvan Posted October 31, 2022 Senior Member Share Posted October 31, 2022 Should we all be eating black chokeberries? A study shows that mitochondrial dysfunction of the dermal papilla cell --> cellular senescence via p16 --> inhibition of normal paracrine signaling pathways is the culprit. From another post: "Cellular senescence is really key to why treating the androgen side of the equation typically leads only to maintenance after the first 6 months of treatment and not significant regrowth (especially of the original, juvenile hairline). Senescent cells aren't easily repaired and/or cleaned up by the immune system (especially with age) and regenerated. They're also known to infect neighboring cells via SASP. Simply limiting serum/tissue androgen levels or even using an AR antagonist might really not be enough to bring senescent DPC cells back into the cell cycle." Link to study: https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-022-00800-7 Other studies on DPC senescence: https://pubmed.ncbi.nlm.nih.gov/17989730/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828374/ I ordered some berries---they are a great antioxidant. Link to comment Share on other sites More sharing options...
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