Baldness Study--DHT-induced senescence was proven earlier this year to be cause?---we may be getting closer to answer!

[Mountinvan]

Should we all be eating black chokeberries? A study shows that mitochondrial dysfunction of the dermal papilla cell --> cellular senescence via p16 --> inhibition of normal paracrine signaling pathways is the culprit.

 

From another post:

 

"Cellular senescence is really key to why treating the androgen side of the equation typically leads only to maintenance after the first 6 months of treatment and not significant regrowth (especially of the original, juvenile hairline). Senescent cells aren't easily repaired and/or cleaned up by the immune system (especially with age) and regenerated. They're also known to infect neighboring cells via SASP. Simply limiting serum/tissue androgen levels or even using an AR antagonist might really not be enough to bring senescent DPC cells back into the cell cycle."

 

Link to study: https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-022-00800-7

 

Other studies on DPC senescence:

https://pubmed.ncbi.nlm.nih.gov/17989730/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828374/

 

I ordered some berries---they are a great antioxidant.