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Posts posted by GuitarPlayer
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All of the doctors mentioned in this thread do excellent work and have great reputations. Since it sounds as though you live in close proximity to all four of them, I would consult with all of them.
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CAMBRIDGE, Mass.--(BUSINESS WIRE)----Curis, Inc. (NASDAQ: CRIS), a therapeutic drug development company, today announced that the Company has entered into an exclusive worldwide research and development agreement with Procter & Gamble Pharmaceuticals, a division of The Procter & Gamble Company (NYSE: PG), to evaluate and develop potential treatments for hair growth regulation utilizing Curis' Hedgehog agonist technology. Future efforts may be expanded to address other skin disorders. To date, Curis scientists have demonstrated that small molecule Hedgehog agonists can induce hair growth in pre-clinical models.
Under the terms of the agreement, the Company has granted P&G an exclusive, worldwide royalty-bearing license for the non-systemic, dermatological use of Curis' Hedgehog agonist technology, via topical administration. Curis will have an option to co-develop a development candidate through Phase II clinical trials. Curis will retain rights to veterinary applications of the technology. P&G has a first option to negotiate a collaboration for veterinary indications in the field of dermatology. Curis continues to retain rights to certain non-systemic applications of the Hedgehog agonist technology, specifically for local cardiovascular and ex vivo use.
"Procter & Gamble's expertise in pharmaceutical development, combined with their solid track record in creating market-leading hair and skin care products, makes them an excellent choice as a partner for our hair program," said Daniel R. Passeri, President and Chief Executive Officer of Curis, Inc. "This is the second collaboration agreement structured to provide Curis possible co-development opportunities. Collaborating with major pharmaceutical companies to execute clinical programs is one way to build Curis' internal development capabilities to re-apply to our in-house programs."
P&G has agreed to pay Curis a $0.5 million initial payment and up to $2.8 million in preclinical milestones, contingent upon achievement of certain preclinical goals. P&G has agreed to make cash payments to Curis assuming successful completion of certain clinical development and drug approval milestones. If a development candidate derived from the collaboration is successfully commercialized, P&G has agreed to pay a royalty on net product sales. At the time of filing an Investigational New Drug Application (IND) with the U.S. Food and Drug Administration, Curis will have the option to co-develop a product candidate through Phases 1 and 2 of clinical development. If Curis exercises its co-development option it will be entitled to a higher royalty percentage on net product sales of any successfully co-developed products although Curis would forgo two early clinical milestone payments from P&G. Assuming that the collaboration continues for its full term, with at least one product commercialized by P&G worldwide in two indications and developed directly by P&G on a global basis, Curis could receive more than $100 million in milestone payments. Such milestones would be payable whether Curis elected to co-develop a candidate or not.
Curis' Hedgehog agonist program was exclusively licensed to Wyeth Pharmaceuticals in January of 2004. Under the terms of the license agreement, Curis retained the right to develop Hedgehog agonists for topical treatment to stimulate hair growth. The license agreement was subsequently amended to broaden Curis' development rights to include topical applications to treat or prevent skin diseases or disorders and Wyeth has approved a group of Hedgehog agonist compounds for use in Curis' retained programs.
Curis scientists have demonstrated that small molecule Hedgehog agonists can induce hair growth in pre-clinical models. These results were presented in February of 2005 at the annual meeting of the American Academy of Dermatology. In this study, a small molecule Hedgehog agonist, when topically formulated and applied to the skin, triggers the transition of hair follicles from the resting to the growth phase of the hair cycle. The authors of the study conclude that the topical application of a Hedgehog agonist may be effective in treating hair disorders, such as male pattern baldness and female pattern hair loss. In the United States alone, approximately 80 million men and women suffer from hair loss.
"We believe that this collaboration with P&G provides additional validation of Curis' proprietary expertise in the field of signaling pathways," said Passeri.
About Curis, Inc.
Curis, Inc. is a therapeutic drug development company. The Company's technology focus is on regulatory pathways that control repair and regeneration. Curis' product development involves the use of proteins or small molecules to modulate these pathways. Curis has successfully used this technology and product development approach to produce several promising drug product candidates in the fields of cancer (under collaboration with Genentech, which also includes a co-development arrangement for a basal cell carcinoma product candidate), kidney disease (licensed to Ortho Biotech Products and under development at Centocor, both subsidiaries of Johnson & Johnson), neurological disorders (under collaboration with Wyeth), hair growth (under collaboration with P&G), and cardiovascular disease. For more information, please visit the Curis web site at [promotional link removed by forum moderator - Robert]
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CAMBRIDGE, Mass.--(BUSINESS WIRE)----Curis, Inc. (NASDAQ: CRIS), a therapeutic drug development company, today announced that the Company has entered into an exclusive worldwide research and development agreement with Procter & Gamble Pharmaceuticals, a division of The Procter & Gamble Company (NYSE: PG), to evaluate and develop potential treatments for hair growth regulation utilizing Curis' Hedgehog agonist technology. Future efforts may be expanded to address other skin disorders. To date, Curis scientists have demonstrated that small molecule Hedgehog agonists can induce hair growth in pre-clinical models.
Under the terms of the agreement, the Company has granted P&G an exclusive, worldwide royalty-bearing license for the non-systemic, dermatological use of Curis' Hedgehog agonist technology, via topical administration. Curis will have an option to co-develop a development candidate through Phase II clinical trials. Curis will retain rights to veterinary applications of the technology. P&G has a first option to negotiate a collaboration for veterinary indications in the field of dermatology. Curis continues to retain rights to certain non-systemic applications of the Hedgehog agonist technology, specifically for local cardiovascular and ex vivo use.
"Procter & Gamble's expertise in pharmaceutical development, combined with their solid track record in creating market-leading hair and skin care products, makes them an excellent choice as a partner for our hair program," said Daniel R. Passeri, President and Chief Executive Officer of Curis, Inc. "This is the second collaboration agreement structured to provide Curis possible co-development opportunities. Collaborating with major pharmaceutical companies to execute clinical programs is one way to build Curis' internal development capabilities to re-apply to our in-house programs."
P&G has agreed to pay Curis a $0.5 million initial payment and up to $2.8 million in preclinical milestones, contingent upon achievement of certain preclinical goals. P&G has agreed to make cash payments to Curis assuming successful completion of certain clinical development and drug approval milestones. If a development candidate derived from the collaboration is successfully commercialized, P&G has agreed to pay a royalty on net product sales. At the time of filing an Investigational New Drug Application (IND) with the U.S. Food and Drug Administration, Curis will have the option to co-develop a product candidate through Phases 1 and 2 of clinical development. If Curis exercises its co-development option it will be entitled to a higher royalty percentage on net product sales of any successfully co-developed products although Curis would forgo two early clinical milestone payments from P&G. Assuming that the collaboration continues for its full term, with at least one product commercialized by P&G worldwide in two indications and developed directly by P&G on a global basis, Curis could receive more than $100 million in milestone payments. Such milestones would be payable whether Curis elected to co-develop a candidate or not.
Curis' Hedgehog agonist program was exclusively licensed to Wyeth Pharmaceuticals in January of 2004. Under the terms of the license agreement, Curis retained the right to develop Hedgehog agonists for topical treatment to stimulate hair growth. The license agreement was subsequently amended to broaden Curis' development rights to include topical applications to treat or prevent skin diseases or disorders and Wyeth has approved a group of Hedgehog agonist compounds for use in Curis' retained programs.
Curis scientists have demonstrated that small molecule Hedgehog agonists can induce hair growth in pre-clinical models. These results were presented in February of 2005 at the annual meeting of the American Academy of Dermatology. In this study, a small molecule Hedgehog agonist, when topically formulated and applied to the skin, triggers the transition of hair follicles from the resting to the growth phase of the hair cycle. The authors of the study conclude that the topical application of a Hedgehog agonist may be effective in treating hair disorders, such as male pattern baldness and female pattern hair loss. In the United States alone, approximately 80 million men and women suffer from hair loss.
"We believe that this collaboration with P&G provides additional validation of Curis' proprietary expertise in the field of signaling pathways," said Passeri.
About Curis, Inc.
Curis, Inc. is a therapeutic drug development company. The Company's technology focus is on regulatory pathways that control repair and regeneration. Curis' product development involves the use of proteins or small molecules to modulate these pathways. Curis has successfully used this technology and product development approach to produce several promising drug product candidates in the fields of cancer (under collaboration with Genentech, which also includes a co-development arrangement for a basal cell carcinoma product candidate), kidney disease (licensed to Ortho Biotech Products and under development at Centocor, both subsidiaries of Johnson & Johnson), neurological disorders (under collaboration with Wyeth), hair growth (under collaboration with P&G), and cardiovascular disease. For more information, please visit the Curis web site at [promotional link removed by forum moderator - Robert]
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Two things. Firstly, hopefully hair multiplication will be a reality by the end of the decade. Secondly, Robert you had an awesome hair transplant. You must be thrilled with your results.
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I have heard of getting 200-300 grafts through FUE, but I seriously doubt MHR are offering FUE.
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Maverick,
The most effective meds to take (and the only ones that are FDA-approved) are finasteride (Propecia/Proscar) and minoxidil (Rogaine/Regaine). This is your best bet to hang on to the hair you have.
I have read mixed reviews regarding Revivogen. As far as ScalpMed is concerned, I'll just say continue doing your research. I don't want to get sued.
GuitarPlayer
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I agree with Specs. You don't want to go for strip with a session that small.
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It's too bad that Dr. Woods won't share his techniques with other doctors as he seems to do great work and has a very good reputation amongst his patients.
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SpotlightKid,
Instead of buying Propecia you can buy Proscar and cut it into fours. This is what a lot of guys do and it can save you a lot of money.
GuitarPlayer
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Stillhere,
Good luck with your results and keep us updated with your progress.
GuitarPlayer
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Anyone know how Dr. Cooley is coming along with his cloning/hair multiplication research?
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Don't let location deter you from finding an excellent surgeon. How far are you from Minneapolis? You'll find one of the best hair transplant surgeons there, Dr. Ron Shapiro.
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I use Kirkland brand from Costco. It's $20 for a four pack of 5%. Walmart's brand, Equate, is also pretty cheap. They all contain the same active ingredient, which is minoxidil.
You could probably start with the 5%, but I definitely would not recommend starting with the 15% that you can buy from some websites off the internet.
A lot of guys on here, including myself, only use rogaine once a day. The application would typically be at night. Hope this information helps.
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Doesn't anybody know someone who went to the convention?
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Nizoral is the only shampoo I know of that can affect DHT levels. I have never heard of the shampoo you mentioned and I have never heard of caffeine being an effective ingredient against hair loss. I aggree with the other member who said to get on Propecia ASAP.
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Gorpy, how many grafts are you getting and what norwood level are you?
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I was experiencing a burning sensation in the back of my throat (along with heartburn) and my doctor told me it was acid reflux.
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From pictures I have seen I think Dr. True does some of the best hairline work.
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I thought I had read somewhere that Dr. Charles was doing a study with the lasercomb. Anyone else know about this?
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When was this award first created and what other doctors have won it? Congratulations again to Dr. Ron Shapiro.
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Anyone know what was discussed at the Convention in Sydney? Any updates on cloning?
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Anyone know what was discussed at the Convention in Sydney? Any updates on cloning?
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Well deserved. So is it all of the ISHRS physicians in attendance who vote on this?
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Anyone who went to the conference going to give an overall review of what was discussed this year?
Need Opinions On NY Docs!!
in Hair Transplant Reviews
Posted
I would consult with True, Bernstein, Epstein, and Feller and make my decision from there. All four are excellent doctors and have great reputations.