Hair Tomorrow

I notice Verteporfin's wikipedia page has now edited out any mention of scar-healing - previously, there was mention of the clinical trial of Verteporfin on cleft pallet. https://en.wikipedia.org/wiki/Verteporfin I suspect there is a concerted effort by the authorities to downplay Verteporfin's potential for scar-healing - and I am guessing it is to stop people buying up all the Visudyne whilst there is a shortage. I've done searches for Verteporfin and military, with zero articles coming up, which is very strange - surely the military would be testing it? Something weird is going on with this stuff.

Verteporfin is very relevant to HTs so I would leave it here.

Yes, but not repeatedly on the same patch of skin, right?

I emailed all the co-authors of this study, finding that IN MICE, after wounding, YAP is activated on Day 2 and Day 7, asking if it is known what days after wounding in humans YAP is activated... https://www.sciencedirect.com/science/article/pii/S0022202X15366033 One of the study authors, Han Sung, replying, having done no such test on humans, but expecting YAP expression to take place within the first 2-3 days after wounding. Has anyone heard any discussions about what days after wounding YAP is expressed in humans, and whether keeping Verteporfin around at the cite of the wounds for longer, by for instance, the use of slow release nanoparticles, or a slow release hydrogel dressing, would be beneficial or not for improved regeneration in FUE extraction sites, as has been seen in animal studies? If you were designing a slow release delivery system for Verteporfin, how many days would you keep it around the wound for?

Verteporfin has been pumped around the whole blood system of many humans, but has not been deposited in one small concentrated area repeatedly. it would be good to know what happens to mice wounds that repeatedly get regenerated with Verteporfin at the same spot.

So they tested Verteporfin on mice, rats, rabbits, and pigs, but did all these trials then kill the trial animals, or have there been any animal trials where Verteporfin-treated animals' life spans have been measured too?

Does anyone know if Verteporfin will regenerate the Erector Pili muscles that go with each hair follicle?

Is it medical grade VS-6062 and 3, or just research grade? There appears to be another FAK inhibitor already in pill form, Dasatinib - has anyone tried applying that to wounds?

And here is another 2023 study I just paid $15 to read, for another kind of nanoparticle suspension slowly releasing Verteporfin at the site of the wound for over at least 7 days, improving Verteporfin's effect at regrowing skin and hair (although not by much over Verteporfin alone - the previous different nanoparticle studies I linked earlier in this thread had more impressive results). I am wondering if research teams focusing on slow release nanoparticles are going to be biassed, insisting Verteporfin alone isn't sufficient, or is more toxic, when it really might be fine as is - perhaps these research teams are globing on to Verteporfin's success, attempting to keep their nanoparticles relevant and part of the mix.

And here is another 2023 study I just found (this one free to read): Hyaluronic acid-modified and verteporfin-loaded polylactic acid nanogels promote scarless wound healing by accelerating wound re-epithelialization and controlling scar formation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369727/

I just paid $12 to read the study you linked that just dropped, "Verteporfin-Loaded Bioadhesive Nanoparticles for the Prevention of Hypertrophic Scar", and it looks like there may be a good reason to add slow release 10,000th of a milimetre nanoparticles to the Verteporfin mix, as it keeps the Verteporfin where we want it for longer, at the site of the wound, blocking the YAP pathway - I just found another study, entitled Yap and Taz Regulate Skin Wounding" where it says on the opening page "... Interestingly, YAP is expressed on the nucleua of the dermis at 2 and 7 days after wounding... " https://www.sciencedirect.com/science/article/pii/S0022202X15366033 Using bioadhesive nanoparticles with Verteporfin reduces risk of liver toxicity as well as extending the presence of Verteporfin locally, at the site of the wound.

I tried DMing @FutureDensity as I would like to present Dr Bargouthi's protocol to an HT surgeon I have found in London prepared to experiment with Verteporfin, who I am meeting next week - but this website says I am not allowed to DM, so please can you post Dr Bargouthi's protocol here?

I messaged the UK's health ministry yesterday asking why there is a shortage of Verteporfin, and given the emerging demand for scarless wound healing, for Britain to start producing its own supply.

I have found a surgeon interested in performing a Verteporfin test on me here in London. Dr Bargouthi has stated that he is interested in experimenting on local patients, due to the need for monitoring post surgery, so in my opinion, we should be putting pressure on local HT surgeons to perform small Verteporfin tests on us individually - if they can source MEDICAL grade verteporfin for special off label use - anyone know where I can order some medical grade Verteporfin for use here in London, with a link I can direct my willing doctor to?

Does anyone know precisely how many FUEs were extracted from the 0.4 Verteporfin region and control region? Does anyone have photos of both boxes having been freshly operated on, so we can count the scars, versus total number of hairs in the boxes, and compare them to total number of hairs after the experiment? If the Verteporfin regenerated hairs in the donor region are fractionally less robust for transplantation in the future, but grow if left alone, then it will become necessary for the surgeon to identify which hairs are Verteporfin generated hairs, to avoid extracting those, and instead extract the original hairs - do surgeons have the technology to guide them to the old hairs for extraction? How would it work?

Micro-needling alone might stimulate some hair growth, so it might be an idea to do one heavy micro-needling session on two small areas of the frontal forelock, treating one region with Verteporfin, the other without Verteporfin as a control, following the same low light exposure during and post op for several days.

If through repetitive micro-needling you get Verteporfin into your bloodstream then are exposed to bright light, that might cause problems.

Injecting filler into certain areas of the forehead carries risks of hitting the wrong vein and causing instant blindness, but microneedling verteporfin more superficially sounds like someone should give it a go (although if it isn't deep enough to wound the hair bulb, then I'm guessing it won't regenerate a new hair bulb).

Please post a link to the Verteporfin info document shown in this vid so I can send it to HT surgeons in London and the rest of UK.

Any ideas about which surgeons in the UK might be the best option for us to approach and ask if they will do a Verteporfin FUE test?