Fabio69

1 minute ago, Jonathan said:

Lmao, used verteporfin to catch some extra views. What a mess this is slowly becoming. 

Agreed. I was actually looking forward to his videos. No other news from dr barghouthi. 

Update from the youtuber THEHAIRCHEMIST regarding his verteporfin FUT trial

https://youtube.com/@TheHairChemist

On 6/8/2023 at 1:31 AM, alopeciaphobia said:

Absolutely amazing, Melvin. Just amazing. So many of us without the network and the connections have been wondering that there must be a couple of courageous doctor's out there who are as intrigued by this as we are. But we couldn't do much about it, no matter how much we wanted.

But you did it! And I'm just so thankful for that, because quite frankly there aren't many others who could've!

Really really really hope this one goes through, so we can learn more about the ideal dosage. Once the ideal dosage has been established, I'd like to take the plunge and get the treatment myself. I'd fly back and forth across the world a few times for checkups if I have to.

Agree with the people above that getting a doctor with a large following, like Linkov, on board could be key to skyrocketing awareness of this. Haircafe and hairliciously etc can post about this all they want, but if someone with professional credibility would start talking about this, other doctors will be less likely to brush this off as yet another broscience miracle cure.

Agreed.

@Melvin- Moderator, do you think you could get Dr Gary Linkov involved. If you got him involved. He could do both hair transplant with vert and healing wounds from plastic surgery using vert. 2 birds one stone.This is his work email at City Facial Plastics

Email: info@cityfp.com

Website: https://cityfacialplastics.com/contact/

On 6/4/2023 at 11:04 PM, MrFox said:

@Melvin- Moderator Do you have any plans on trying to get non hair transplant surgeons on board? Perhaps broadening out to some plastic surgeons might be worthwhile. At the very least the drug significantly reduces scarring, I can't imagine there isn't a cosmetic plastic surgeon who wouldn't be interested. It might be beneficial to see the drug work on a part of the skin without the intention being hair replication, but rather skin regeneration. 

Should try and get Dr Gary Linkov involved, considering his big following

8 hours ago, HairEnthusiast101 said:

Oh only once into the scars? Have we seen what effect it has on fut scars? Would be massive?

It must be done straight after extraction but the first FUT verteporfin case is from a youtuber called THEHAIRCHEMIST. He will be documenting his results on youtube. Link to channel below.

On 6/2/2023 at 9:35 PM, HairEnthusiast101 said:

Are trials just injection into donor right after hair transplant surgery or is this injected every week for months?

A one time injection right after extracting follicles using FUE or FUT. Lets hope we get a good amount of regrowth

2 hours ago, Melvin- Moderator said:

Guys,

 

 I agree with Kevin on the blood flow theory. But this thread is about Verteporfin.

Hey melvin,

Is there any more updates on the upcoming verteporfin trials/new trials happening

In the 0.4 verteprofin FUE transplant, does anyone know what the percentage regrowth was. Was it 30%, 40%, etc.

4 minutes ago, -TheHairUpThere- said:

This is the most exciting thing that's happened in the hair industry in decades. Especially as somebody with a thinner donor area. Gonna wait for these trials before I schedule my next HT. Hoping for the best. Hell if this actually works I might even get me a full beard too😎.....the future is finally looking bright fellas. 

Hopefully, the end of hair loss is near

9 hours ago, Fox243 said:

@Hairgain if ur interested in following up, there's a derm I was talking to almost a year ago who was interested. Her name is Dr Anastasia Therianou. She liked the idea of verteporfin but wanted to see more proof, so maybe you can show her Dr. B's latest photos and express your interest to her.  

If someone could get her on board, i can create more posts on tressless, and the hair trasnplant forum on reddit and many people will be interested

9 hours ago, Jonathan said:

Is Dr Barghouthi still starting his trials early May? Anybody still in contact with him? 

Yes, he is still doing trials in MAY. One of them being the youtuber called "THEHAIRCHEMIST" who is i think undergoing his FUT next week. He will document it on youtube

17 hours ago, Melvin- Moderator said:

Anyone in the LA area, send me a PM. I will connect you with Dr. Mohebi. 

Hey melvin, great work.

I created some posts on reddit about surgeons who will want patients for verteporfin trials and hopefully more people are aware and are in contact 

19 minutes ago, Hairgain said:

I'm not familiar with all three treatments Amplifica is pursuing. Could you find me a link that tells about them please? I've been to their official web site, it doesn't relate much.

https://folliclethought.com/updates/

https://www.google.com/amp/s/medicalxpress.com/news/2022-10-san-diego-biotech-million-bald.amp

There is not much info on there other 2 main hair loss treatments compared to scube 3. But these 2 treatments are their main treatments not scube 3

5 minutes ago, Hairgain said:

Well it was the COVID-19 with Tsuji and due to this his investment went dry. Now he has some backing. Is it enough? I doubt it. He's reorganizing with a different team. He's had difficulty finding investors in the past and went to the public to raise money. Something doesn't seem right. Tsuji seems to not want to do live interviews.

Fukuda did come up with something sound to present lately. Too bad though it was with a mouse. Mice should really be disallowed from experimenting for a hair loss cure related to humans. They're too different. The mice regrow hair easily due to gamma delta t-cell locations and greater proliferation compared to humans, their skin is more flexible and they grow hair and shed all at once unlike humans typically do. They're too different. My guess is Fukuda Lab is working on cloning human hair now. The thing to keep in mind is there is a real possibility of cloned hairs taking in humans. It did in 2015 but grew in awkward directions. Word has it Amplifica recently got new hairs to grow for 9 months, also they grew not like the rest of the hairs and the newly generated ones failed to cycle. I think the major challenge in human hair cloning is going to be the cycling issue. There's some lack of signaling issue with these cloned hairs in humans that doesn't allow for them to regenerate (cycle) from what I read. I have no idea how they're going to figure out this complexity.

Worst among them is Stemson. It seems they never have anything solid to report regarding advancing their method of hair generation. No progress to report in years. Huge staff but nothing to show for it. The CEO seems to be avoidant as possible unless he has no choice. 

Of all these players I would place bets on Fukuda Lab having the best chance. 

I find what Dr. Bargouthi is doing to be fascinating and working but am concerned as to what the final result is going to show from an aesthetic standpoint. Sure we see new hair growth but also the areas where the FUE grafts were taken still show white scarred looking skin. The FUT results should be more telling I think. The Red Duroc Pig result using the FAK Inhibitor VS-6062 showed hair regeneration but then the area of scarring on the edge of the wound seems still present. It's the black outer background surrounding the regenerated hairs. So we have improvement with these methods but is it a perfect result? I doubt it but is greatly improved nonetheless. 

 

Amplifica have athree hair loss treatments and one should be going into trial at the end if this yr. But if verteporfin can just reduce scarring and regrow hair then most individuals would probs be happy with that. Lets hope.

9 hours ago, Hairgain said:

Verteporfin seems like it's becoming the new liquid gold for the follicularly challenged. The FAK inhibitors though deserve a shot. It's been tried on people for cancer. Wondering if Dr. Bargouthi might try? Best part is it can be applied to the surface to work, injection not necessary. 

I'm also anxious for Fukuda Lab at Yokohama University to surprise us with terminal quality human follicles that take and cycle. They got it figured out for the mice, now we need to get it to the wo/men. 

Then there's Organ Tech and Dr. Tsuji. He has a cure but seems to never get off the ground. 

Plus there's Stemson Therapeutics which basically likes to hire people to work for them and the rest of what they do is a secret they can't tell. 

In hair we care. 

Fukuda, tsuji, and stemson want do anything they just delay and waste time. I hope i am wrong. Fukuda planned on human trials this yr but probs will not happen. Tsuji said trials in 2020 but nothing happend.

4 hours ago, arthurSam said:

So minox is better

Well , overall, minox regrew on all mice, but the level of growth was near complete using GT20029 on the mice that regrew hair. They must be confident if they are already in phase 2 of human trials

On 2/13/2023 at 5:36 AM, Ghostbusters said:

Kintor Pharma Announces Positive Top-line U.S. Phase I Trial Results of GT20029, the World’s First Topical Use PROTAC Compound 

 

LLOQ, with the highest not exceeding 0.015 ng/mL.

 

In preclinical studies, by degrading androgen receptor (AR) protein, GT20029 could block the shrinkage and miniaturization of hair follicles which was caused by the activation of AR signaling pathway. As the result, it prevented the hair from thinning, softening and falling out. GT20029 could also effectively inhibit sebaceous gland development and sebum secretion. With limited skin penetration, GT20029 could avoid high systemic exposure and achieve a better safety profile. The repeated pharmacodynamics studies in dihydrotestosterone (DHT)-induced mouse model showed that GT20029 significantly promoted hair growth, with statistical difference. The study of testosterone propionate (TP)-induced skin hamster flank organ acne model showed that GT20029 significantly inhibited enlargement of flank organ, with statistical difference.

 

Dr. Youzhi Tong, founder, Chairman and Chief Executive Officer of Kintor Pharma, commented, “The positive U.S. Phase I top-line results of GT20029 in 123 subjects has shown a similar result with that of Phase I trial in China with 92 subjects enrolled. Both studies have demonsrtated the good safety and tolerability in MAD of GT20029. Alopecia affects about 1.6 billion people and acne affects about 0.72 billion people worldwide, there are huge unmet clinical needs. We will accelerate the initiation of Phase II clinical trial of GT20029, maintain our leading position in the development of topical PROTAC drug candidate globally. We believe that GT20029 would strengthen our market position in the dermatology area, together with our novel drug KX-826, to provide a diversified portfolio of therapies to patients with AGA or acne. ”

 

About GT20029

 

GT20029 is a topical AR degrader developed by Kintor Pharma’s PROTAC platform. The China National Medical Products Administration (NMPA) and the U.S. Food and Drug Administration (FDA) cleared GT20029's clinical trial applications for treating AGA and acne in April 2021 and July 2021, respectively. In August 2022, Kintor Pharma had completed the enrollment and dosing of subjects for its China Phase I clinical trial. In November 2022, Kintor Pharma announced the top-line results for its China phase I clinical trial. In October 2022, Kintor Pharma announced completion of subject enrollment and dosing in its U.S. Phase I clinical trial.

I found this on reddit about GT20029

On 5/3/2023 at 8:54 PM, Follicle1984 said:

Im with Melvin here. If it works and is without sides...the price seems very reasonable to me. I understand everyone is in a different financial place...but I would gladly fork this out to achieve maintenance alone! I would likely pair it with other things I can tolerate too. Roll on pyrilutamide and GT20029 for the ultimate stack 🤤

Just to understand the verteporfin trials going on, is it just the 3 FUT DR BArghouthi trials in MAY

2 hours ago, MrFox said:

Perhaps we could invite him and create a thread on here for him? It just might be helpful to ask him some direct questions. I'm really curious to see his point of view, coming from someone who has had both FUE and FUT procedures before. I wonder if there will be a noticeable difference in recovery from the patient's point of view in regard to tension and nerve sensations in the healed area. 

We need to make him aware of this forum

3 minutes ago, Melvin- Moderator said:

Oh well, it looks like a fitness influencer with a lot of followers reached out to Dr. Umar, let’s hope it goes well  🤞 

Nice one melvin, the movement has begun. Lets just pray all this works and we get unlimited donor area. Amen

They removed all 3 of that guys verteporfin posts

54 minutes ago, Melvin- Moderator said:

Unfortunately, it looks like the post was removed from Tressless. Can anyone figure out why? This isn't anything promotional. I can't understand why they would remove an effort to get more surgeons to try Verteporfin. 

7 hours ago, mr_peanutbutter said:

awesome; did someone already posted this on tressless?

Just looked, someone has posted it on tressless

28 minutes ago, Fox243 said:

Maybe also show him how popular this thread has gotten -- it might be the largest thread on HRN. This verteporfin video has over 100k views: 

.  I also have the doc that I made to help doctors into it -- it's a bit outdated but still useful: https://docs.google.com/document/d/1s3JkF9woMIebkXbpE_UxrjBfNy9i7AuBclDqn9HGrAo/edit

He needs to do a microneedling experiment, over thinning/slick bald areas.

3 hours ago, IberianChad said:

I would also add Jake Kent: https://www.youtube.com/@JakeKent/videos

His channel is not focused on hair loss treatments per se, but rather towards hair systems and related topics. Still, a prime audience for this type of thing. Specially since those who wear hair systems are usually too far gone for most standard treatments, they need a cure or extremely effective treatments. And since most probably gave up on the usual, there's likely not a big intersection with the channels you already mentioned. Worth a DM imo! @Melvin- Moderator

I couldn't find his email but his IG is @jacob_t_kent and i believe he's also one of the mods of the /r/HairSystem/ subreddit. So maybe someone can try contacting him through those.

Precisely. The first thing that came to mind when i first read about the verteporfin study was that guy! Maybe he had a weird mutation or a "glitch" happened in the healing process that made him heal without scarring, basically what we're expecting Verteporfin to do. A great reason to try it with micro-needling or some other, more aggressive, wounding. The hair that grows on the sides of my head is not as good quality as what i used to have on top so if possible i'd rather recover that, even if i have to repeat the procedure more times.

For those that don't know what we're talking about here, watch this:

On a similar note, this Rob English guy is probably also a good person to contact, he's a medical editor and seems interested in all sorts of obscure research and the science behind hair loss. He also has a closed community of hair loss sufferers and seems well connected, having appeared in the HUGE channel, "What I've Learned"(+2M subs).

Absolutely the more the merrier. Rob english talks about fibrosis and scarring which is why he uses the scalp massages. Verteporfin through the pig skin trial does exactly that, stops the scarring, hence healing the skin, hence regrowing hair follicles.

At least Dr Barghouthi is doing more trials, just need to make sure other surgeons are doing trials using different techniques and  dosages This has hope.