Follicle1984

On 11/10/2022 at 10:43 PM, Geza said:

So I went with the Regenera Activa. The doctor I saw actually spent the time to explain all the workings of not only the surgical options but all the non surgical. All the doctors I saw before her, where rude at best, spent max 5 minutes and all wanted to do hair transplant with varying numbers from 2200 to 3500! The two men doctors I saw are supposed to be the best with the most experience in the field of hair transplant in my area, and one woman doctor that just did not give me any confidence in her abilities.

One of the major off putting part was their rudeness, lack of interest in me and my hair loss.........I felt like I was car that they were deciding on what type of breaks I need.

Maybe this is because all 3 of them were old and do not care about customer service anymore.....anyway the doc I saw was younger, friendly, she did not hurry, you could tell she lives hair loss and hair transplant, answered all my questions....even gave me her cellphone number to reach out if I have more questions (that never happened to me before)....after my consult, she told me to go home think about what we talked about, think about her recommendations and also shop around to make sure I was getting what I wanted. Loved her take: "Trust your gut, you will know when you find the right doctor for your needs!".....I think she won me right there and there! Went home did a little more research, called her with a couple of questions and she answered via text, and did the procedure 1 week later.

I am excited to see how the Regenera Activa works on me! 

Hi

Can you update us about your results with regenera activa? I am considering it as I have few options.

Anyone else had this and able to comment?

Thanks

19 hours ago, Melvin- Moderator said:

I wanted to let the community know that CosmeRNA reached out to me. I have asked for a phone call to discuss some of these issues. My hope is that someone can join a podcast to talk about some of these concerns. 

Hi Melvin,

I don't think I'd be free to join the call but I'd be happy to list afew questions you could consider asking. Happy to private message them to you if you like.

On 8/16/2023 at 10:30 AM, arthurSam said:

New problem with CosmeRNA :

 

 

Can I ask you Arthursam...how long before you noticed a reduced shed on cosmerna?

10 hours ago, FUEtile said:

I mean is that a big problem? It’s 0.4 difference. I guarantee most companies do this. Even protein powders come half empty. This company is attacked a lot. 

Well on a positive note that poster on reddit says he was actually happy with the product and it seems to have halted his hairloss. Obviously being underdosed is not good...but other than that. It does seem I'm reading some good things in various places about cosmerna and that it is stopping shedding in some people. Which is perhaps all we could ask for in these early months.

I've now started to use it. Second application in. Nothing to note yet. Shedding appears the same. I'm using afew other things though too. But this is the new player, so I think any changes will largely be attributable to this.

2 minutes ago, Joseph James said:

You may be into something with that. I'm glad we have intelligent people like yourself in this forum.

Why thank you 😊  I try my best.

Well I've come across one or two people who are more intelligent than myself with regards to metabolic chemistry...and there are some interesting hypotheses withbregards to how there may be alot of other things at play and interlinking with the androgen paradox. 

When I stopped to think about it all, I realised perhaps my finasteride side effects may relate to my overall health more than i cared at first to beleive. I think the issue is aswell with insulin resistance is that it can be hard to diagnose. Needing fasting insulin levels and not simply fasting sugars. And if this is out of whack it could cause a whole host of issues. 

I'm on a mission to clean up my metabolic chemistry at the moment.

15 minutes ago, Joseph James said:

That is possible, or it may have had an interaction with the blood pressure medication I take. A hair transplant surgeon seemed to think that might explain my negative experience with finasteride.

That interesting. I've begun to wonder if finasteride and 5AR sexual side effects may possibly be related to insulin resistance, metabolic syndrome and endothelial dysfunction. 

Some evidence that dutasteride mesotherapy is less effective in insulin resistance also.

5 hours ago, Joseph James said:

I stopped taking it after the second dose. I used the full recommend dose the first time I took it, and the next day I had irritability/ anxiety similar to when I took finasteride, but not as bad. Tried it again 2 weeks later with a much lower dose, but still had the same thing, though not as severe so I stopped.

Thanks for sharing.

Not discrediting your experience...but do you think there is a chance this may have been nocebo? After all, the mechanism this works by, causing reduction of the AR, should take a little time to come into play and equally take some time to rectify and rebuild levels of AR. If the symptoms came quickly and left quickly, it does make wonder if this MAY have been unrelated. 

The mind is a powerful thing after all.

Anyone with any updates on cosmerna?

7 minutes ago, arthurSam said:

Yes I think too. I cannot take topical minox 2x/day anymore because I cannot apply any based water product with fluridil. So now I take only topical 1x/day at morning and fluridil at night. When I take cosmerna I take  nothing else for 24h.

I tried to take 0.5mg of oral minox added to the topical but I cannot tolerate oral minox even at a such low dose.

It's a tricky one isn't it.

I recently had some ED with alfatradiol too. I was reading into it. Turns out although 17alpha E2 is a weak estrogen in many tissues it can apparently act as a stronger estrogen in some other tissues...one being the brain. Which actually makes sense with me.

Just have to find out what works for each of us i guess.

7 minutes ago, arthurSam said:

No but even with fina I was not concerned by that.

Ah OK. Thanks for clarification.

Good you are working with a urologist I guess then. I'm glad cosme seems not to be giving you sides.

The study from dermatest supposedly showed better results with twice weekly anyway so maybe no better than weekly. I think pairing it with an androgen receptor antagonist seems a good idea.

1 hour ago, arthurSam said:

Hi,

I apply it every 2 week but if i was rich enough i would do it every week like in the research paper...

You could try cosmeRNA for sure I hope it will stop your hair loss...

Concerning sides, I still have small discomforts and prostate-type pain but since I stopped finasteride it's much lighter. I don't think the fact that I take CosmeRNA + Fluridil maintains these pains but I'm not sure either... It's hard to know... I am followed by urologists but things are progressing very very slowly...

But no Erectile dysfunction on cosme?

On 7/18/2023 at 12:15 AM, arthurSam said:

Hello,

I am 47yo

I got a HT last year and got a shock loss but my hair regrowed later. After that I was a lttle hair loss on shower every day (10-15 hairs).

So for stabilization, I tried topical finasteride 3x/week 0.025% 1ml with alcool. My hair loss stopped but I got sides 4-5 months later. So I needed to stop it.

Then, I tried with trichosol but same thing.

Then, I tried with liposomal + sicicone (Xyon gel bought at parati pharmacia) with 2% but same thing.

Then I tried Xyon Dutasteride at 1% but same things.

I tried also oral minox 1mg/day but got sides (heart and renal problems - saw after a blood test of renal filtration rate wich has diminished). So I stopped oral minox and no problems anymore then (my renal filtration rate is now normal).

Now I am on fluridil + cosmerna since 2,5 months (with topical minox 5% at morning too from a while now) and it works great (no hair loss anymore on shower). I got just little side (no morning wood) for few day (1 or 2) after the day of application of CosmeRNA.

I take vitamins too + zinc.

It seems I am very responsive to sides from topical medication, perhaps because I got a atopic skin.

Hi Arthur Sam.

Can I ask do you apply cosmerna every week or every 2 weeks?

Also...thanks for sharing your encouraging story. I too had awful sides from fin (both oral and topical) which has made me very nervous to even try topical dut. I figure I may give cosme a go...afew people stating its stopped their shedding. I'm shedding badly at the moment. So would be nice to have something to at least stabilise my loss.

I presume still no side effects with cosme?

Thanks

On 5/13/2023 at 11:28 PM, Joseph James said:

I just did.

How you getting on with cosmerna?

20 hours ago, JasonElva1990 said:

arent those photos more as a marketing picture to show how the effects can look in the end result? Some HT clinics were doing this kind of thing years back before they actually achieve results and real photos from their patients.

Im still giving Cosmerna a chance because many marketing stuff goes that way.

It's to early probably for them to post or even get pictures from patients if they were lanunched 3 month's ago.

 

 

For example,years back my friend had a Hp surgery in my country in a local plastic surgery clinic.

There was literally only one real photo of a female and male with before and after result.

Nothing more from patient results.

 

Their main photo of the clinic was a male model with photoshop.

 

My friend when asked if he can send him results after a year said yes etc but in the end he didn't do it although his end result was pretty decent,not impressive but not bad anyway compared to todays Fue.

 

Just sayin. 

 

If Cosmerna is a Scam,we will find out after some time. One year and we will definietely know  

 

 

I think I agree with you.

As much as I agree with Melvin that any company faking before and after photos is not on (if that's what's happened here). That being said, It could be a disconnect... poor marketing decisions vs the science.

Hopefully, the product at least may halt hairloss and prove an alternative to fin and dut. If it does this without sides, I'm taking that as a positive. 

As you say...we will know soon. Arthur Sam's testimonial is encouraging. 

Anyone any further updates with their Cosmerna usage/results/sides?

On 7/12/2023 at 11:01 PM, Melvin- Moderator said:

Yea, but photoshopping is so dumb. I could understand posting a before and after in favorable lighting, maybe at a different angle. But doctoring the results makes the brand look horrible. I’m gonna see if I can gather more information on it.

I would appreciate any information you can get hold of.

I agree. I never had any postive results from taking oral saw palmetto.

I'm actually had some old bottles of hairmetto that I hadn't really used much of. So I've decided to restart use and really monitor my shedding and see what happens.

I have to credit Derek at MPMD with his video advising a hair catcher in the bath/shower. Given hairloss is a real long term game, where you may not see actual visible results for 6 to 24 months, having a tangible metric like how many hairs you shed, can be an invaluable took to guide you on if something may actually be working and you just need to stick with it.

Who knows how many treatments I may have started in my past but never carried on beyond afew months because I didn't see any instant effect. To be honest, I now view just halting progression as a major victory. So maybe I gave up on topical saw palmetto way too prematurely last time. The good thing is when I used it for afew months I never had any noticible side effects. Certainly nothing like what finasteride did to me.

Apparently many saw palmetto brands use inferior extraction methods. So I'm guessing not all products are equal. I'm still not sure what does the heavy lifting, ie beta- sitosterol vs certain fatty acids. Maybe a combo. But I guess it's those things which you want a lot of in any topical.

I'm going to use the oil at night, then a non greasy saw palmetto in the mornings.

Let's hope we can see some decent results.

If it blocks even a bit of 5AR, it will mean that topical androgen receptor blocks have less work to do. Throw in a AR reducing drug/product like cosme or GT, and I think there may be a potential of a very potent stack. 

On 7/3/2023 at 4:14 PM, mustang said:

Quick update: Shedding has gone up a little. I normally lose 5 hairs daily when washing it (on average, sometimes none, sometimes 3, most times 5). I shed very little hair as most is transplanted and those tend to shed even less.

The last 2 weeks it's gone up to 15 per wash and they all come from the area where I am applying the product.

Hopefully that's a good sign.

 

Good to hear mustang.

Keep us posted.

Im considering cosmerna to be honest. Along with an androgen receptor blocker. 

I was reading that even gamma linoleic acid that blocks 5AR does so irreservably at least somewhat, which does make me a little concerned for finasteride-like side effects which may linger on afew weeks after disconinuation if they occur.

Presume you've not noticed any side effects?

Update...

You've inspired me to hop back on topical saw palmetto mustang. I had such bad experiences with fin, that I just couldn't get over the fear and try topical dutasteride. I figure topical saw palmetto and pyrilutmide might work well instead.

I have heard oral saw palmetto only has about 18% of it arrive at the skin and scalp. So maybe it is a whole different beast when used topically, especially with some microneedling once a week. Will keep you posted. 

On 7/2/2023 at 7:20 PM, DaveWheeler said:

Hi everyone. I just did my second application of Cosmerna. No sides. Penis function is normal to this point. No brain fog, tiredness or sleepiness. I do micro needle as well. Cosmerna is the only drug I am using at the moment. No issues with shipping, I am in Canada. Obviously, nothing to report in terms of re-growth. I did not experience shedding. I did not notice a change in hairs on my hands while shampooing. It's the same as it was before. Hair also looks and feels the same. For the record, In the past, I did take low dose topical FIN and experienced all the penile side effects, weak erections, weak ejaculations and some numbness in the groin region within days of use. I didn't know if this was placebo or not but frankly I didn't care. I stopped use and regained normal function of my penis. So, in my opinion, this is positive news for my Cosmerna treatment and I hope I can remain side free and begin to get thicker hair in the coming weeks to months. P.S the once ever 2 week application is a game changer..... it's a dream over the once or twice daily application. 

Cheers Dave. Great to be getting good quality feedback like this. Very thorough and helpful. And really good (to me at least) that this feedback is coming from someone who got fin side effects (I also did!). So hopefully if someone like you can tolerate cosme without issue, it gives a lot of us hope. Thanks for the updates and please do keep them coming.

I agree the once every two week application sounds like a dream. At one point I was trying to apply topicals 3 to 4 times a day to maximise results. Twice daily is hard enough. 

19 hours ago, mustang said:

CB only competes with Testosterone for me, not with DHT. 

A combination of Topical Fin or Dutasteride with CB0301 is a good combo. 

I tried Hairmetto but it's a mess to apply. 

So the saw palmetto topical you are using is trichometto? Do you know if they ship to the UK?

Is it standardised to a percentage or concentration of fatty acids?

The hairmetto states 85 to 95% fatty acids. CO2 extraction which is apparently best method.

8 hours ago, mustang said:

Alfatradiol is quite weak for men but in combination with progesterone it's very good on women. It's also good for men on TRT with Finasteride included.

I guess having fatty acids blocking 5AR half of the day is better than nothing.

My 20% means there is 200MG per ml so I am getting 400mg to 600mg every time I apply it (I do 20 puffs to 30 puffs, 1ml equals 10 pulses)

CB0301 is being sold and has been around for a while with the proper vehicle from several vendors, you don't need to wait for 2025 to try it. It's the same compound. Some people get fatigue (HPA issues), others don't have sides but the ones that did recovered within days of stopping.

I think at 1% to 2.5% it's safe to issue but you might need to supplement with DHEA or Pregnenolone (if causing adrenal issues).

It's tricky but safer than RU for sure and also weaker.

For now I see no changes with my protocol which is good, I am not losing much hair (2-3 strands a day).

I guess an overload of fatty acids from both Saw Palmetto and Pumpkin Seed oil plus the dermarolling and the growth factors of Trichoxidil is as good as it gets naturally. You can add a laser cap on top of that.

Time will tell

But CB0301 was tested at 7.5% BD...and I beleive showed good safety? I doubt a weaker strength would be effective for AA as its not a very strong anti androgen mg for mg (I beleive...relative to DHT at least). Probably need at least 150mg per day topically to stand a chance of fighting the good fight. 

Well...let us know how you get on with saw palmetto. I suppose if the concentration is high enough and from a decent quality product, you may be luckier than many who have failed with it. I'm sure microneedling can only help with absorption. I may even be tempted to give my hairmetto non oily another go 🙂

I'm hoping cosme will be a hit...that would be great news for us all 🙂🙂

So just after I mentioned I'd not heard about CB 03 01 for ages, follicle thought article announcing it'd FINALLY entered its phase 3 study. I thought it had been dumped...but I think it's way more to do with the company merging or something maybe. So...2025 it may be out.

Also mustang...I realised I also had an old bottle of the hair metto non oily which also has saw palmetto..it contains 200mg per 5ml of CO2 extracted saw palmetto standardised to 85-95% fatty acids. What percentage would this make it? What specific ingrediant is your 20% standardised to?

So your thoughts are saw palmetto is only really effective topically?

I suppose if you could get a very high dose to the follicles and may even applied multiple times a day...it could maintain a higher level of the fatty acids needed to block 5AR. I believe it blocks both type 1 and 2?

I guess the good thing with fatty acids being your 5 AR blocker is their half life is very short...both a pain as you need to apply very frequently (I bet 4 times a day would be better than 2 if possible...but totally unfeasible unless you never leave the house haha). But this same fact means even if it worked its way around the body and you got sides, I bet the side effects would not last long. 

Also regarding sides...I wonder if these fatty acids bind in a suicidal manner to 5AR? I beleive finasteride and dutasteride bind and never let go? So if you get sides you need to wait ~90 days to rebuild all your lost 5 AR (i think this accounts for a lot of longer lasting sides*). Whereas if the fatty acids dissociate after afew hours, if you got sides, waif afew hours and your back to normal. Hmm...need to try and do some research on this!

*of of the docs on the hairloss show states he always felt the halflife for fin IN THE TISSUES was actually much longer than afew hours...more like weeks. Whether that lasting in the tissues is actually because it never let's go of the 5AR once bound (suicidal binding) and as the enzyme may last weeks, it is technically in the system for longer?!

Finally...have you ever used alfatradiol? That ca  supposedly act as a topical 5AR inhibitor.

3 hours ago, mustang said:

The fact that is has been approved as a cosmetical when it degrades receptors is shady to say the least. 

Also the price putts me off. 

Pyrilutamide has a bad side effect profile. It's quite strong. CB0301 never took off but I know of people using it with success but most didn't adhere, true.

I am hoping the natural route will do it for me.

I thought pyrilutamide was pretty safe when I read the studies?? No reports of much other than scalp irritation?? Where did you read it had bad sides?

I think with cosme, it all depends how systemic it goes...like with topical dut. My personal opinion is almost all topicals must go systemic to some degree, its probably just a case of how much and what their half life is until they degrade into something else, and if that that something else has any inherent effects of its own. If there were bigger studies on cosme showing safety and blood serum levels of the compound after use (like they did with pyrilutamide) I'd feel a bit more comfortable.

Overall I just wish they had more efficacious drugs which worked on non androgen pathways where there was just no risk if anti androgen side effects. I wish they had done more with topical ciclosporin. It showed quite a lot of promise in the small studies done.

OK...so you may think this is whacky but have you ever read about botox use for androgenic alopecia? I've been experimenting with scalp massage recently, and weirdly I think I've seen a reduction in shedding. Seriously considering botox as when you read the small scale studies done, they had comparable results to finasteride!

2 hours ago, mustang said:

Cause of pregnencancy attemps.

Yes, I have seen that video and the results are good indeed but that serum is a nightmare to apply. The one I use is hydrosoluble and dries within minutes. It also has trichoxidil which works great and your right, you have to be consistent and can expect miracles but if I can have maintenance and slight thickening then it's a win for me.

I have no opinion on CosmeRNA , it's too early to tell, seems promising but also quite strange and pricey. I have my reservations.

RU works but it's a dangerous chemical with potential heart issues, I would never touch it. CB0301 is much safer.

I wish you the very best of luck 👍 🙂 let us know how you get on with it. Trichometto looks interesting. 

I agree CB 0301 seems safer. However it's seems to have stalled. Not heard anything about it for years. Pyrilutamide will be released first I think. Will be awesome when that's commercially available. GT20029 I think may be the best.

I agree about cosme. I think I have resigned to wait for at least afew more months before trying it. The idea of something preventing ARs developing elsewhere in my body if it goes systemic, which I have seen no data to say why it theoretically can't, is off putting (for me at least).

Hi Mustang.

Can I ask why you no longer take topical dutasteride? Apolgoes if you've already mentioned this somewhere already.

I tried hairmetto...a topical saw palmetto. Granted I probably didn't give it long enough to work, but I didn't really see anything obvious for the couple of months I used it. Not sure I put enough on really either. Very greasy so it required twice daily hair washing which became difficult to maintain. Good video on YouTube documenting a guy who microneedled with hairmetto for several years and supposedly got fairly good results (as long as he was genunine and honest and not using fin and not telling us...I think he seemed genuine).

What are you thoughts on cosmerna? And RU?