DrTBarghouthi

No both locations. As for s volunteer, I didn’t find one yet. There are few interested but I still have to see the suitability, logistics etc

Hi guys, Hope you’re all having a lovely weekend. Just few updates regarding the last trial and some other issues. 1. The patient came back for his monthly follow up. He is doing well in general. The hair was quite long so the photos weren't showing the areas clearly but I did take photos and it shows typical FUE healing although I did feel them to be slower than surrounding ones (similar to how they behaved in the first trial). They still looked red and demarcated, while in other areas -where No Verteporfin was injected- they started to look like typical scarred tissue. I have asked him to come back so we can clip the donor again sometime this week or next week. He just has some event he needs to attend prior to shaving it again. I will take more photos when he gets back so I can share them. I think clipped hair will show the areas better. 2. I am invited to present about Verteporfin in the upcoming WFI workshop in May. Hopefully this will spark more interest in further studies with colleagues. 3. I am considering another trial mostly regarding old FUE scar extraction. 4. I’m also glad to share that I will be doing consultations and performing surgeries on a regular part- basis at the Westminister Medical Group in Harley street-London. Thank you again for all the feedback

Yes I believe this is worth looking at.

Yes. The one month is due next week. We will do 1-2 month follow ups most likely.

I will update following the one month follow up which is sometime next week. 🙏🏻

No complaints or side effects with all the patients who had it injected.

Hi guys, Just to clarify a couple of things to some respected members of this group: 1. The Full FUE patient’s wish was to remain anonymous. He shares videos and photos with me and we both are pleased with how his donor looks. Nonetheless, these are photos and videos shared by him and have no scientific basis that I can use as validation or proof. At this stage, we want to provide as much objective evidence as possible. Sharing videos and photos of the full FUE (even if patient allows) based on patient photos isn’t scientific and could be seen as feeding the hype for monetary reasons and to encourage more patients to do it. He could simply be having great donor healing with or without Verteporfin. 2. Furthermore, as we are trying to gain more momentum and doctor involvement, I thought that a more detailed trial using better photography and site marking would give us a more scientific approach than the first trial. It also allowed me to increase the doses used without having to cover large areas. 3. My current intention is to get scientific trials to go ahead and advance. This takes time and takes on a scientific approach rather than just feeding the hype. If the intention behind this was to raise money only, then the way I’m approaching this would be completely different. In our industry, we make money by attracting patients. I’m currently trying to attract Doctors.

Hi guys. Many thanks for the positive feedback and messages. I will publish some photos of the follow up . The patient came today for his 10 days followup. Thankfully everything was good in terms of no adverse effects or allergic reactions reported. I’ll publish some photos soon. I will also like to reassure you that I will hopefully proceed with further trials as seen necessary and looking forward to collaboration with other Doctors mentioned.

Yes. I aimed to make the area as small as possible in order to be able to go back to it. I extracted 7-8 follicles in each spot. I will provide the other details of density etc that I have. I technically aimed to keep the spot very small and heavily extracted in order to be able to see any changes with better clarity.

Areas marked 35: 0.4 mg Verteporfin Areas marked 36: 0.6 mg Verteporfin Areas marked 37: 0.8 mg Verteporfin Areas marked 38: 1 mg Verteporfin Hi guys, Just wanted to share some photos of the latest trial. We have marked the areas injected both using a spot measure and also Scalp Micropigmentation. 7-8 follicles were removed from each marked area within the actual boundaries of the SMP. The removed grafts were all inspected and there were no transections seen. 0.4 mg Verteporfin (Before and after injection immediately) 0.6 mg Verteporfin (Before and after injection immediately) 0.8 mg Verteporfin (Before and after injection immediately) 1 mg Verteporfin (Before and after injection immediately)

The entire area is a control (apart from these 4 tested spots).

I think we will follow up closely to see how the process is evolving in the donor. It could be 3 or 4 months for preliminary effects to show.

What we essentially did is try to get a very close look at the a small spot of extracted grafts and be able to confidently go back to the same exact spot. Once we defined the exact spots we wanted, I extracted a set number of grafts from it. The before and after photos were taken, even measuring the diameter of the extraction sites. All extracted grafts were checked and photographed under the microscope to check for transection- luckily none were transected. We then injected Verteporfin in several doses and took immediate after photos. I will do a serial follow up of all these areas. In order to go back to the extracted zones, we have both a marked spot using tricholab’s spot market and also SMP around the entire area of extraction to border them out from the rest of the extractions.

Sorry for the confusion. I meant the mid part of the donor area scalp.

Hi guys, Apologies for the silence. We just finished an FUE case and injected 4 different doses of Verteporfin in specific areas of the mid scalp in order to be able to go back to the exact spots. We used SMP around the areas extracted but also measured precisely the location of each of the spots. The dosages used were: 0.4 mg, 0.6, 0.8 and 1 mg. Photos were taken using the Tricholab system. Will update and share shortly. Happy to hear about all the updates from the community and @Melvin- Admin

Hi guys, I do understand the frustration of the ongoing delays and I just want to reassure you that such delays were beyond anyone’s control. We did have multiple issues with suitable volunteers in terms of their availability and follow up potential, as well as the ongoing issue of making sure that we have a reliable and constant supply of the medication. In addition to that, it did take us some time to arrange and purchase any missing equipment that we need for a more objective study. It is important at this stage to carry out decent trials - for purposes of being objective and as scientific as possible. Having said that, there has been steady progress taking place in the background. We do have two volunteers. One Volunteer will have a full FUE with Verteforfin, while the other one will have Verteporfin injected in the bald areas of his scalp to see if there could be any potential improvement or growth. We have also managed to engage with a suitable supplier that can provide us with Verteporfin. I am placing a test order with them in these coming days to make sure their process is smooth. We have also received the photography device we need for research. I have booked two dates for these two trials- but I will refrain from mentioning the exact dates so as not to cause any further disappointment for now. Finally, I have seen some nice recovery photos from our FUE patient who had his donor fully injected with Verteporfin after 2-3 months ago, and his donor is looking good. I will check with him if he wishes for his photos to be shared.

Hi guys. I totally understand and I will update you with details by the end of this week- We are going ahead and nothing changed in terms of that.

Hi guys, Hope you’re all well and I very much appreciate your enthusiasm and persistence- including @Melvin- Adminand all the others here who supported this in one way or another. We did a full FUE on one of our booked patients and injected verteporfin in the entire donor area as per his request and desire. As mentioned previously, this does not fall under the full FUE trial that is planned. The procedure went well and to be honest I’m not sure if the patient is active here or is willing to share his updates publicly or not- I will leave that up to his personal choice. Nonetheless, from our side it was uneventful with nothing unusual to report after few days of having it done. As for the next trial, the patient is ready. The delay was mainly to make sure he has no major travel plans so that follow up can be scheduled easily. Moreover, I am waiting on a research grade trichoscopy analysis system for the donor which we are waiting for approvals here to get. This will help in getting accurate analysis of the extracted sites and better photos etc. I’m hoping we will have the system in the coming week or two and then we can slot in the patient for the trial. I’m just keen that we get the best out of this one and to be able to provide objective measures publicly. Will keep you updated regarding that ofcourse.

Hi guys, Hope you’re keeping well. Apologies for keeping you waiting again. It was a busier than usual period in the last few weeks and I just landed in India for the annual hair conference. As mentioned in a previous post, I continue to see the consistent difference between injected and control sites. I think the 0.4 area has been showing the best overall progress- but I also think that we do notice changes in the other doses too. The zoomed out 0.4 area looks to me untouched- but that’s only my subjective judgement. I was also happy to see the 0.24 mg area catching up to show better visual recovery and that might be due to the fact that this area had tumescent fluids injected in it, leading to vasoconstriction. This might be leading to a more localised effect of Verteporfin in the region. I have uploaded the photos here. As for future trials, I had one planned for the 24 th October, but I pushed him back because of the conference. I thought it would be important to follow him closely in the first few weeks and I didn’t want to be away in his initial recovery. We agreed to do it in November as he also has no travel commitments or difficulties with regular follow ups. We also have another patient who will be potentially having Verteporfin in November along with his procedure. I think the optimal dosing is not too far off. I am still keen on increasing the dose slightly- or at least in some areas.

Hi guys, Apologies for the delay. I like to process the photos myself and I couldn’t get to that yet in clinic. Nonetheless, I know most of you are waiting for some sort of update. I had a look at the areas and the patient and I must say I’m quite happy with how the 0.4 mg and to some extent the 0.32 mg areas have developed. The 0.4 mg I found to be nicely healed . I will share the photos ofcourse but thought at least to give some update of what I saw thus far.

Hi guys. I did follow up with the first patient and took some photos. I must say a quick view of the patient showed a nice 0.4 mg site. I’ll arrange the photos and share them once I download them- just wanted to update.

Both patients have virgin donors.

I think we need to optimize the “new scar” trials and see what Dr. Bloxham’s revision trial yields and then yes that can be a possibility.

And I apologize for the recent silence- even across the forum. I’m actually busy with the induction of 2 new doctors who joined my practice and whom I think will be of value in helping with research and clinical work going forward.

Hi guys, I have few updates: 1. I have a scheduled follow up with the first trial for this coming Wednesday. The patient had several work trips and so our schedules weren’t working well. Hopefully we will have an update on him this Wednesday. 2. In view of Dr. Bloxham’s recent trial and him trying higher doses of Verteporfin, I think there is a potential to trial even higher doses to see if the effects can be optimized with higher doses or we should be maintaining a narrow range of testing. I have booked the trial for the 24th of October but my Volunteer patient is having constant difficulties with time off work. He is an ideal candidate- so I don’t want to give up on him yet. Hopefully we will have that done with him on that date. 3. I have also scheduled another trial for November 21 with another patient who is also having a full FUE. As mentioned earlier, I have the Verteporfin ready for both of these trials.