found an interesting article online on msn

[Naruto]

i hope its not too illegal to cut and paste

i am not taking credit only want people to read and give input......

 

WASHINGTON - Mice with deep skin wounds can grow new hair, scientists said on Wednesday in a finding that offers hope for a baldness remedy for humans.

 

The mice regenerated hair at the site of the wound via molecular processes similar to those used in embryonic development, according to the research, published in the journal Nature.

 

The findings show mammals possess greater regenerative abilities than commonly believed. While some amphibians can regenerate limbs and some reptiles can regenerate tails, regeneration in mammals is far more limited.

 

Dr. George Cotsarelis, a dermatology professor at the University of Pennsylvania School of Medicine in Philadelphia who led the study, said the findings dispel the dogma that hair loss is permanent in people and other mammals, and that once they are lost new hair follicles cannot grow.

 

Cotsarelis said the findings could pave the way for remedies for male-pattern baldness and other types of hair-loss. He said the idea would be to apply compounds to get epidermal cells to turn into hair follicles.

 

The regenerated follicles functioned normally, cycling through the various stages of hair growth, and the hair was indistinguishable from neighboring hair with a key exception -- it lacked pigmentation and was white.

 

The otherwise brown-haired mice had patches of white hair marking the site of the wound.

 

Cotsarelis said the white-hair issue may not materialize in any baldness remedy in people because the human pigmentation system differs from that in mice.

 

New hairs formed

The researchers made relatively large wounds on the backs of adult mice, and found that if a wound reached a certain size new hairs formed at its center, with the skin undergoing changes mimicking stages of embryonic hair-follicle development.

 

Dormant embryonic molecular pathways were activated, sending stem cells "??? master cells able to transform into other cell types "??? to the damaged skin.

 

The stem cells that gave rise to the regenerated follicles were not stem cells usually associated with hair-follicle development.

 

"They're actually coming from epidermal cells that don't normally make hair follicles. So they're somehow reprogrammed and told to make a follicle," Cotsarelis said.

 

The researchers also found a way to amplify the natural regeneration process, causing mice to grow twice as many new hairs by giving the skin a specific molecular signal.

 

Cotsarelis is involved with Follica Inc., a privately held start-up company that has licensed the patent on the process from the University of Pennsylvania. He said it probably would be more than five years before a treatment was possible.

 

Cotsarelis also envisioned treating wounds in a way that would leave skin with hair follicles, sweat glands and other normal attributes that would be functionally and cosmetically much better than a scar.

 

Dr. Cheng-Ming Chuong, a professor of pathology at the University of Southern California who was not involved in the study, said it proved the principle that hair can regenerate from adult skin, but cautioned that human skin differs from mouse skin.

 

"Repair and regeneration appear to be in competition," Chuong said by e-mail.

 

"Since fast-closing wounds help the survival of wild animals, repair often dominates regeneration. In the practice of medicine, physicians are trained to close wounds as soon as possible, thus leaving not enough time for regeneration to occur."

 

Copyright 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content is expressly prohibited without the prior written consent of Reuters.

 

http://www.msnbc.msn.com/id/18703259/

[Willit]

This came out in our local paper in Hawaii, but referenced the Philadelphia Inquirer. I pulled this from the philly site:

 

This is the actual link

http://www.philly.com/philly/news/breaking/20070516_A_n...for_hair_growth.html

 

A new possibility for hair growth

By Tom Avril

INQUIRER STAFF WRITER

RELATED STORIES

 

* More about the report

* Follica Inc.

 

Though they can regrow part of the liver, humans and other mammals are generally thought to be incapable of true regeneration - growing a new organ or limb when it has been lost entirely.

 

But today, University of Pennsylvania dermatologists report they have indeed performed this feat of biological renewal, regrowing a "mini-organ" that is a sore subject for millions of older men: hair.

 

The researchers, whose findings appear in tomorrow's issue of the journal Nature, said they cut out small pieces of skin in mice, thereby triggering a genetic pathway that normally goes dormant after embryonic development. New hairs grew on bare patches where follicles had been completely removed, and the process worked especially well when researchers artificially boosted levels of a special signaling protein.

 

So far, the research has not been done in people, but already the wheels of commerce are churning: a startup company has licensed a patent related to the research, and one of the authors has a stake in the venture. The findings are of interest beyond the multibillion-dollar hair-loss industry, shedding light on how doctors might do a better job of healing people with burns and other wounds.

 

Bruce Morgan, an associate professor of dermatology at Harvard Medical School who was not involved with the research, called the research by Penn's George Cotsarelis "striking."

 

"He reprogrammed the cells to regenerate those organs from scratch," Morgan said of the hair regrowth.

 

Cotsarelis, who holds a stake in the startup company, urged people not to try wounding themselves in a misguided attempt to regrow hair. That alone would not have much success.

 

"I'm kind of afraid of people misinterpreting this and incising the scalp," he said. "Don't try this at home."

 

He said any clinical treatment would also require the application of a product, ideally a topical cream, that would boost the special protein pathway.

 

The results appear to confirm a finding reported by a another Penn dermatologist more than 50 years ago. Albert Kligman, a professor emeritus who is better known for inventing the wrinkle cream Retin-A, reported that tiny new hairs grew in wounded skin. But his research was not well received, he recalled this week.

 

"People made fun of that paper, because they said . . . the epidermis of an adult is incapable of producing new follicles," Kligman said. "Sometimes happily you do something, and it sinks out of sight, and then it's rediscovered 50 years later."