Gwazi

Okay so if it “didn’t regenerate 100%, not even close” in Barghouthi’s trial, how much did it regenerate? I have never seen another person ever say “oh yeah that looks like only 25% regeneration at most” when looking at this picture lol. I’m not sure why you’re choosing to die on such a weird hill, when it’s pretty obvious that looks like more than 25% regeneration. Probably not 100%, but it looks untouched, unless you want to claim Barghouthi is wrong and it’s not untouched, it’s actually 75% thinner than the surrounding hair. You realize that you are the one that brought up a number in the first place right? Someone was talking about theoretical full donor area regeneration and then you say “well actually it will only regenerate 25% of your hair at most” which is an extremely weird and unfounded claim. Lastly, you aren’t following my logic that if it can regenerate 25% of your hair, then theoretically it can regenerate all of it? Okay then. Let me try to explain. If verteporfin can regenerate one hair follicle, why wouldn’t it be able to generate the hair follicle right next to it which is pretty much the same? Can you give me a reason in which one hair follicle can regenerate but one can’t that’s right next to it? To me the only reason I can think of is not a strong enough dosage or the procedure needs to be altered in someway. So let’s say we got the dosage and procedure perfect, then theoretically every hair should be able to regenerate. Like is there a big difference between hair follicles in your donor area where half can regenerate and half can’t? I sincerely do not understand why 75% just are unable to regenerate as you claim. It doesn’t make sense to me Sorry if Im coming off as rude, Im not trying to be

okay but this is just straight up ignoring Barghouthi’s first case study then which he showed an update at around a year and a half and you are just cherry picking the Bloxham trial which (correct me if I’m wrong) was an FUT transplant and the last update we got was around 5 months after the surgery lol. 5 months is nothing and Barghouthi’s patient wasn’t all that impressive at around 5 months either, certainly not as impressive as the 1.5 year update. It certainly doesn’t look like only “at best 25%” of grafts regenerated in the Barghouthi trial. And regardless of that, it was the very first hair transplant verteporfin trial. The process could be fine tuned and improved to improve the result over time. If verteporfin can regenerate 25% of grafts, then it theoretically can regenerate 100% of grafts. Since all your grafts in the donor area are essentially the same, why would it only work on a quarter of the grafts? That doesn’t make much sense. That would just mean we need to tweak the dosage to increase the hair regeneration rate.

Holy crap man massive respect to you! I’m very excited to see what it looks like in 6 months or a year. Here’s to hoping verteporfin can regenerate some hair follicles!

Hey, have you done it yet?

You’ve tried microneedling and injecting verteporfin already or you tried just microneeeling deeply?

Good job finding that. When was the 2nd FUE trial started? Looks like he will probably try that after this current FUE trial. So I got my answer to my original question

Bro accuses me of using a strawman then in the same message acts like I said that Verteporfin will definitely 100% bring the original hairline and density back. Dr. Barghouthi has stated that he wants to test injecting it into completely bald areas. If verteporfins mechanism of action made that impossible, then barghouthi wouldn’t waste time and money trying it

Ah yes, we are the ones who have no idea what we are talking about. Totally not the guy who can’t even simply google “can microneedling deeper than 1.5 mm damage hair follicles?” (The answer is yes). How in the world am I ignorant to verteporfins mechanisms and the basics of hairloss? As stated previously, Dr Barghouthi said he was interested in testing this out. He’s literally the one pioneering verteporfin for hair transplants right now but you are gonna claim he doesn’t know how the mechanism works? As you said, if you can damage the hair follicle enough, then potentially verteporfin can regrow it. Well there you go. Glad you were able to figure out what the whole point of the experiment would be. If you are such a verteporfin expert please enlighten us on why it wouldn’t be able to regenerate dormant hair follicles if you were able to damage them enough. Also, verteporfin blocks scarring allowing your skin and tissue to regenerate. Yet if we try microneedling and injecting it, apparently we will be left with permanent scarring? At this point you are just pretty much arguing that Verteporfin doesn’t work for wound healing either, which we know to be false. You can go look at the few cases studies on RealSelf to see it working Anyways, you aren’t a scientist or a doctor, so not sure why the heck you are in here trying to discourage Dr Barghouthi from doing that experiment that he already said he is interested in

The mechanism of this drug literally just regenerates skin and tissue and follicles instead of letting it scar. Saying "the mechanism of this drug would make injection after microneedling not work" is just blatantly false. According to the mechanism of this drug, it should work. Not to mention people on RealSelf have reported using this drug to "cure" their scars, and it works perfectly. Even on older scars. There isn't even a trace of scar left. So if we destroyed the dormant hair follicles, and used Verteporfin, it would regenerate a hair follicle. You said it would probably just regenerate a miniaturized hair follicle. But why? That doesn't make sense. If it is completely regenerating a hair follicle, why would the new hair follicle come back already killed by DHT? No, it would more likely come back as a new hair follicle that is DHT sensitive and can in the future miniaturize again assuming you aren't on meds. But it would probably come back as a new hair follicle. What don't you get? I am way more hopeful for this than verteporfin after a hair transplant because I would prefer to get my original hairline and density back instead of a hair transplant which will look worse! This would be so much easier and cheaper than a hair transplant, and assuming it works, much better too

@DrTBarghouthi Hey doctor! Are you still going to look into injecting verteporfin after microneedling or damaging dormant hair follicles in some other way? I’m extremely interested in the potential for Verteporfin to be able to regenerate hair without a hair transplant. Sorry if this was previously asked in this thread. Also, do you think it will work or not? Thanks!