jondoeuk
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Posts posted by jondoeuk
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Tretinoin upregulates follicular sulfotransferase enzymes, which metabolise minoxidil to its active metabolite, minoxidil sulfate Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes - Sharma - 2019 - Dermatologic Therapy - Wiley Online Library
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3 hours ago, Scree said:
I firmly believe all the controversy around Finasteride is that it is FDA approved for a purely cosmetic condition. Dutasteride does not get nearly as bad of a reputation and it's arguably a much stronger drug.
It (5 mg) was first approved by the FDA for treatment of benign prostatic hyperplasia (prostate enlargement) back in 1992.
This is an interesting study on the nocebo effect https://academic.oup.com/jsm/article-abstract/4/6/1708/6890112
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On 7/2/2023 at 8:32 PM, TorontoMan said:
Not many positive anecdotes for efficacy in my experience. Two of my friends were on it for a period of time without side effects however, but it might be too mild of an anti androgen to maintain hair.
The current version is 2%, but I know actifolic are selling 5%, 8% or 10%, which could improve efficacy.
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On 7/2/2023 at 11:21 PM, arthurSam said:
I take it with cosmerna since about 2 months and I loss less hairs in my shower ; I am on topical minox too from a very long time
From eucapil-shop?
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Has anyone used dutagen by hemiacosmetics or duderma by minoxidilmax?
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I'll leave this
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On 5/16/2023 at 4:54 AM, shiba1985 said:
isnt pyrilutamide allready avaliable through compounding. I dont know what is so earth shattering about using an anti androgen to treat male pattern baldness. Obviously it will work, but brings all the risks on blocking androgen with it.
Please correct me if i am wrong
No, the grey market. Also, it is generally well-tolerated, with the most common adverse events being localised, such as contact dermatitis.
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6 hours ago, mustang said:
It's Chinese Dutasteride. Watch out, it's of very poor quality and cross contamination is likely.
Thanks. Do you know about some of the others, such as dutagen and lrak tech?
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On 6/22/2023 at 5:04 PM, arthurSam said:
Personally, I am using CosmeRNA since 2 weeks. I no longer have morning wood from about 1 week. I specify that I also use Fluridil from about 1 month so I do not know which med is the culprit...
I am however confident I think it will come back - at least I hope!
However, I feel more tired and I sleep less well... Maybe it has nothing to do with it, I don't know. It's getting hotter and hotter in my house and it's tiring me...
I had this same symptom when I took fina topically. When I stopped I regained my morning erections...
Do you know if it's bad for your health to no longer have a morning wood for long time ?
This must be important for the good health of the penis, right?
From this: ''Sexual functions, libido, hematology, and blood chemistry values were normal throughout, except that at 3 months, in the spring, serum testosterone increased within the normal range equally in placebo and fluridil groups. No fluridil or its decomposition product, BP-34, was detectable in the serum at 0, 3, or 90 days.'' Fluridil, a Rationally Designed Topical Agent for Androgenet... : Dermatologic Surgery (lww.com)
I'm not aware of the company behind CosmeRNA doing the same.
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Anyone using duderma?
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Anyone used it? If so, results and any sides?
pyrilutamide KX826
in Hair Loss Drugs
Posted
ProStrakan, the company that eventually acquired the rights to PSK-3841 (aka RU-58841), ran two clinical trials in humans in the early to mid 2000s. The first was a PhI (n=30) and the second was a randomised and placebo controlled PhII (n=120), but results were never published, nor did a pivotal trial start to bring it to market.
Now we have (non-)steroidal antiandrogens with published clinical data, which are fluridil, clascoterone (CB-03-01) and pyrilutamide.