IberianChad

Well, none of us is "sure" of anything, but my reasoning comes mostly from the fact that miniaturization seems to be caused by a chronic exposure to androgens(or maybe some other unknown factor, like the buildup of fibrosis). It is not something that is "programmed" in that tissue by default, the opposite is true, that's why you used to have hair there. And since we're damaging it and (theoretically) allowing it to regenerate fully without scar tissue, it should be regenerated according to the original "blueprint", not exactly how it was before. For example, let's say you acquired a Gecko super power that allowed you to regrow limbs upon activation, and that you have a scar in your hand, some acquired moles from sun exposure, or even a tattoo. If you ever lost that arm and grew it back, do you think it would have any of those traits? If this power is following a "Biological logic", it shouldn't. In the same way that dyed hair grows with it's original color, rather than with the new color you dyed it with and the reason why people "damage" their facial skin with lasers and acids to make it look younger, by regenerating it with finer wrinkles. You said it yourself: "facilitate the STEM cell". Of course, this would mean that those hairs are still vulnerable to DHT, but given that many are willing to use Anti Androgens or that some miniaturize quite slowly it might be worth it. Also, depending on how many treatments are necessary or if infrequent maintenance sessions are safe and effective, it might be preferable to and cheaper than having multiple hair transplants. Healing works much faster than miniaturization. This is why i don't think very androgenic hair(like beard/body hair) is the best test candidate for this effect. Or even if it is a decent one, it might not be immediately noticeable.

Yea, and since Verteporfin *apparently* insures no scarring of the skin, we could maybe do a less frequent but deeper/more aggressive and medically-assisted wounding. With some anesthesia to make process bearable. Maybe thicker needles too? Considering it might be regenerating punch excisions which are significantly thicker than needles and that the more we "take" the more is "renewed". The entirety of the hair follicle actually goes way below the usual micro-needling lengths of 1-1.5mm, the problem is that when you start going deeper than that, it gets terribly painful and you increase the risk of complications/infections, and afaik, most people do it at home. It makes sense to me that if the hair is almost completely or completely miniaturized, that you would need go deep enough to "rebuild" everything from the ground up. Possibly going 3+ mm to reach the lower layers of the dermis and the hair matrix cells. And as far as i know, this has not been tried yet.

I would also add Jake Kent: https://www.youtube.com/@JakeKent/videos His channel is not focused on hair loss treatments per se, but rather towards hair systems and related topics. Still, a prime audience for this type of thing. Specially since those who wear hair systems are usually too far gone for most standard treatments, they need a cure or extremely effective treatments. And since most probably gave up on the usual, there's likely not a big intersection with the channels you already mentioned. Worth a DM imo! @Melvin- Moderator I couldn't find his email but his IG is @jacob_t_kent and i believe he's also one of the mods of the /r/HairSystem/ subreddit. So maybe someone can try contacting him through those. Precisely. The first thing that came to mind when i first read about the verteporfin study was that guy! Maybe he had a weird mutation or a "glitch" happened in the healing process that made him heal without scarring, basically what we're expecting Verteporfin to do. A great reason to try it with micro-needling or some other, more aggressive, wounding. The hair that grows on the sides of my head is not as good quality as what i used to have on top so if possible i'd rather recover that, even if i have to repeat the procedure more times. For those that don't know what we're talking about here, watch this: On a similar note, this Rob English guy is probably also a good person to contact, he's a medical editor and seems interested in all sorts of obscure research and the science behind hair loss. He also has a closed community of hair loss sufferers and seems well connected, having appeared in the HUGE channel, "What I've Learned"(+2M subs).