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Gatchpt

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Posts posted by Gatchpt

  1. 32 minutes ago, Fox243 said:

    If you don’t think mass emailing doctors will be useful, at least volunteer to help with coming up with new ideas and such to increase regeneration. Read through papers to help theorize optimal doses, injection techniques, etc. There’s so many variables to tinker with to learn about instead of complaining. 

    And there is data – very detailed FUE data in fact with biopsy counts and good quality pictures. 

    There are 2 obstacles for adoption by Drs:

    1. High risk - can only be mitigated by solid proof vert work . And The word theorize is the main problem here, none of us are scientists and most of us Cant comprehend a scientific paper. best we can do is read the abstract and the results sections or at least me.

    2. Credible and reliable Vert supply - I proposed you and your DAO folks find a way to either produce it , or buy it as powder/compound it , partner with a Chinese supplier and white label it … you disregarded the idea. i dont know what you can do but if you fix the supply issue at least we can tell Dr lsn not only you have my full consent if things goes wrong (removing the risk) but I know how you can source the thing,  All we need from you is your skills to do the FUE/FUT  and follow the documentation/dose

  2. 13 hours ago, Fox243 said:

    Rather than complain, can you instead do productive things like mass emailing other docs to try out verteporfin? the only person with a right to complain is arcturus who put in 14.5k or the few members of the community who have done dozens of hours of research like melvin or me who wrote the 20 page vert doc. 

    You know that mass emailing Drs at this stage is useless because they will all want to wait until they see tangible results. That’s why everyone is waiting for the 2 Dr.Bs to share results and expedite trials because once at least one of the them (especially FUT trial) show success then most dermatologists and Ht surgeons will jump on board because that’s mean money for them and means we don’t need to beg them to read a 20 page document if they have the time. Oh believe me if they see results they will have the time! So let the man vent and complain ! We at least deserve that after all this wait. 

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  3. 50 minutes ago, Fox243 said:

    The 15k is being used for the trial. Trials and transplants are expensive. You don’t need a cost breakdown because 15k is so reasonable – at a high level imagine a graft is $5, Verteporfin itself costs $1k, and paying for a patients and doctors time for several follow up visits can easily reach 15k. 
     

    The point to fund an additional trial is so we see if Verteporfin works alone in the first one and concurrently test out other safe drugs. Cancer drugs makes it sound worse than it is when these drugs are completely benign if you do research, as I have spending hours studying these. Why stifle the scientific progress being made if now is a time for innovation? 

    Why not open up both routes , one for public funding (this group, reddit, etc enthusiast) who might donate 10-20$ each, and one for those who wants to trial on themselves and have the money to cover the whole trail cost with Dr.B even if it’s 10-15k. They will pay this amount if they did a normal Ht in the US with a reputable surgeon, so why not pay the same in a lower rate/cost country with a donor regenerative potential.

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  4. 55 minutes ago, Fox243 said:

    HairDAO is an organization that has raised around 3 million dollars and our goal is to cure hair loss. We’ve done a bunch so far such as create a new treatment (that we are putting through trials in the next 6 months), fund various hair related projects, etc. I’m one of the core members of HairDAO. Happy to answer any questions.

    Can you expand more on the new treatment? What is it and what’s the potential? 

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  5. 5 hours ago, Melvin- Admin said:

     

    This video was released two months ago, so something isn’t adding up. How could he have done his first update two months ago and only be at one month.

     

    How come you are standing behind and even glorifying Barghouthi trial and effort but trashing Dr.Bloxham trial! You didn’t even bother contacting him or getting him on your podcast… your dismissing of the man’s trial is unjustified and actually even suspicious. He is doing us a favor too! 

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  6. 3 hours ago, bigmistake said:

    Where did Dr. Bloxham say that there are early promising results ? Can you please share a link.

    Hi. Yeah, I'm working on an update video right now. It will show post-op day 1 through month 1. Then I'll do a 2 month update (just got these photos back from the patients a week or so ago) quickly so I can try and get back on track and do simplier monthly updates from that point onward. Pretty encouraging stuff thus far though. I wish it was easier to get so I could already start setting up new trials with higher dosages and testing for different uses!”

    from the discord 

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  7. 3 hours ago, Melvin- Moderator said:

    I’m sure it’s been postponed for good reason. It’s not because of this phone call. Dr. Barghouthi has to start the trial when he’s ready. Trying to rush him isn’t good. 

    He was ready and sat a date until you woke up one morning with the idea of contacting Dr Longkar who we all know wont share anything, so somehow you created this frustration with the continuous delay and people calling out Dr.B . Also all the “we shouldn’t pressure Dr.B” talk is fine when he was funding the trial from his own pocket as a favor for hair loss community (which we all appreciated and still do) but lets not forget someone here donated 15k for this … I myself donated 20$ which I know is nothing but since he or whoever in this group went the donations route and actually got what they asked for then it becomes a different type of obligation and priority and doesn’t fall under doing us a favor anymore. 

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  8. 1 hour ago, Melvin- Moderator said:

    Sorry guys, he canceled the meeting and rescheduled for August 28th. 

    You have the list of questions we are all interested in Melvin. Why cant we provide it to him via email and ask him or his office/assistant/scientific team to answer it in a written form instead of verbally at least for now. After that if he will have more free time at some point and is actually willing to educate people with his scientific approaches and breakthroughs then a podcast can be arranged as he wishes on the 28th but at least for the sake of dosing and volumes and process of injections it’s even better understood written than verbally. 
     

    on a side note a friend tells me that some group interested in scars tried several times to get answers from him and he refused or didn’t even reply because he is trying to patent the drug and sell his approach as a cure at some point so there is no benefit for him to reveal the recipe to the public. Which makes me wonder if Dr.B holding his trial is even worth it as this stage.

  9. 5 hours ago, Melvin- Moderator said:

    Dr. Mike Longaker, emailed me back. He’s setting up a time to call me. Will report back when I have more news.

    Great news Melvin. I hope he agrees on doing a podcast also. Is it worth coordinating with Dr.B to hold off the trial until you had the call with Dr.Longkar; maybe he’ll shed some light or provide some dosage/ way of injections/ volumes per cm …. That can improve the trial? Just a thought.

     

    great job Melvin! 

  10. From Dr Bloxham Discord:

    Alright, so I think I've finally caught up after the verteporfin trial and wanted to sort of unpack and just share my initial thoughts -- which I thought may be useful/interesting. So, just to recap, I did 3 separate patients, removing 1cm x 2.5cm mini-strips and directly treated (direct dermal injection with the wound open) the areas with 0.4mg/cm^2 up to 0.8mg/cm^2 verteporfin. First, I must say that the trial was a blast! It was stressful and exhausting (I recalculated and realized I was actually at the office for 16 hours straight, and not 19, but you get the point!), but truly exciting. Second, having the 4 hour window to use the reconstituted verteporfin is a bit stressful when you are dealing with multiple patients. It seems like a long time, but I was down to the wire. I had it quite well coordinated too - where I basically had it lined up so I could do all three of the excisions portions back-to-back (opposed to taking tissue and then making incisions and then placing the dissected tissue like in normal FUT) - but I still used pretty much the full 4 hours. Do I think it still would have been good after 4 hours?  Yes. But I was trying to reduce variables. Reconstituing the verteporfin and preparing it in the dark room wasn't as difficult as I anticipated. So that was good. However, injecting it was challenging -- which did not surprise me too much. First, the suspension is VERY dark. Thankfully it's still translucent so you can see through it a bit, but very different from saline, lidocaine, etc -- which are all clear. This is compounded by the fact that you need to inject very small and very precise amounts. Which brings me to the actual injecting: I think injecting the first section on the first patient is something I will always remember. Again, just one of those very exciting moments for those who love science. Continued in the next post ...

     

    It's challenging to get the needle right into the dermis where you want. Very easy to go a little too far towards the deeper tissue and end up in the hypodermis or be too superficial and just get a lot of leaking of the verteporfin. Injecting is hard too because you need to pay attention to both where the needle is located and the volume at which you are injecting. So you're sort of looking back and forth rapidly -- checking the volume you are injecting and making sure the needle is in the right spot. In the future, I will probably have a spotter watch the volume for me and tell me when to stop. It would also be possible to have the correct volume in separate syringes, but then you would have dozens and dozes of these. Next, injecting the solution itself is physically hard. It's very thick and takes some real pressure to get through the needle. This is also compounded by a very fine needle (30 gauge) and a dermal injection -- the dermis is hard and injecting into it is always a little more challenging. I did try different gauge needles (27 gauge to be specific), but I'm not sure how much difference it made. I also found it variable between different patients; some had harder dermis tissue compared to others. And compound all of this with no surgical light too -- but I'll get more into that in a moment. I also found varying degrees of extravasation -- verteporfin leaking out of the injection sites. I had one patient who was bleeding more than average and had thinner blood, and he, understandably, had a bit more extravasation. I had others where the injections were super smooth: clearly in the right area, the right volumes, with very little leaking. It's also extremely cool watching the verteporfin sort of collect in the tissues because it has a very characteristic dark green color. I think we did very well with the light. I didn't use the surgical light for any aspect of the removal, injection, or closure. Continued in next post ...

     

    "I found that using  magnification (7x, which I use when making recipient incisions) made up for this and I was able to visualize everything well. All of the patients responded well to the medication. No allergic reactions, no irritation reactions (apparently a pretty common one when verteporfin injection sites are exposed to intense light too soon), or anything like that. We kept everything covered well and there were no issues with the donor areas the entire day. Surgeries were unremarkable otherwise. The verteporfin treated sites looked really good at the end of the day. Even a little cleaner compared to the non-treated areas. No other real observations that early. I had them all stay pretty well covered and out of the light for 5 days. I followed up with them closely and saw them back at the office multiple times since the test and everything is great without any issues. So I feel very good about the safely profile of the verteporfin (which was pretty well established regardless). There also did not seem to be any problem going up to nearly double the dose used in tests thus far (0.8mg/cm^2). I spoke about this with several knowledgeable colleagues (including Dr Barghouthi) and felt good about it -- and it seems like that hunch was correct. We will see if it makes a difference with regard to healing. So, altogether, I felt quite good with the first trial and I want to do more regardless of outcome. I think I can definitely do better on subsequent rounds (the first time at anything is obviously always never quite as smooth!). I also want to test the other aspects of verteporfin as well. Next tests will probably be a bigger punch left open to see how it heals/check for regeneration, and then I would love to do some wounding with dermarolling or something like that in the recipient area and then treat with verteporfin to see how it does. Last post below ...

     

    I wanted to, again, thank everyone on the server. You guys have been great! I also would love to be included on any other sites, forums, apps, etc where you share future treatment information. I'm always impressed on how quickly you guys find this new stuff! Any other thoughts on where else I should share this? I know there have been some threads on hair restoraiton network. It looks like it's kind of the last forum standing? Hair Loss Talk previously had all the "future" treatment discussion, but I think that one is gone now! I'm going to document everything through YouTube as well. I'll make the announcement video this week and then update with 48 hour pictures, staple removal pictures, etc. And, of course, I will keep this server the most updated and share everything here first."

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