Square1

Maybe I am missing something here, but what is the point of research if the outcomes are being hidden?

According to theory, they should go hand in hand. Whether that is the case remains to be seen, but I do think that if we get scarless healing, donor regeneration is a very real possibility.

The Bloxham-trial started over 3 months ago. He estimated that he could probably draw some preliminary conclusions after 3-4 months. He is, like dr. Barghouthi, probably a super busy guy, so it might take him awhile, but I guess he will be reporting about it soon. It is unlikely that the whole skin of the patient healed without scars, there is probably some optimization we have to do regarding dosages / application methods etc, but if there is a semblance of scarless skin that would be a very good sign that verteporfin works in humans as well. Easily the most promising development in hairloss ever.

The amount donated was just for the verteporfin right? That means that dr. Barghouthi is still doing everything for free and in his own time. He even leaves money on the table, because all the time he is devoting to this project he can't spend on commercially more attractive options. It is great that the money has been raised, it should be handled with transparency and great care, but it is not that the doc took it for himself and ghosted the community.

You can pause the video on any moment you like and capture the screen.

My takeaway from that trial is that it looked like there was substantial regrowth in the Test sites as compared to the Control sites. Especially for the higher dosages. Following up with that patient would, I think, provide a lot of useful info on its efficacy for hair regeneration. For some reason unknown to me it is just not happening. Maybe the patient is no longer available or so.

Again, many thanks for your pioneering! Regarding extra input for the trial, are you in contact with dr. Bloxham about his experiences? Maybe they come in handy when conducting this one.

Dr. Barghouthi is ready when he is ready. Whether that would be today or in a year, or even later. We don't have to despair though, the Bloxham-experiment is around the 2 month mark. He said himself that he expects to draw preliminary conclusions after the 3-4 month mark, so that really isn't far off.

Judging from the video from dr. Bloxham, the application method is also not as straightforward as one might think. Maybe there is some learning curve there as well. And of course, great news about dr. Pittella also joining the list of doctors experimenting with verteporfin. Credits to Melvin again.

Too bad, but thanks for trying though. Could the call maybe be a little bit too much of a commitment? Maybe you can mail him your questions so that he could mail back whenever convenient for him?

If there is a way to contact him it might be useful to ask him about the healing of the skin in his patients. The effect of verteporfin should be that this it is slower, but without scars. After 1,5 month, the skin healing should be about complete under normal circumstances, so if his patients report a slower recovery that could be a sign of the drug working. Nothing to get overly excited or pessimistic about, a faster or slower healing process can have other causes too, but i could be an indication.

Let´s first focus on the effect of verteporfin alone and focus on different dosages, application methods etc. According to theory, that should already be enough. When enough research is in and this effect is well understood, we can look at other ways to improve efficacy if needed.

He is more focused on evaluating that effect of verteporfin, but according to the theory he laid out himself, they go hand in hand. So either they both happen or they do not.

I expect them rather soon, scarless recovery takes longer than a normal recovery. So if verteporfin is working, this should be observed quite quickly.

In theory, you can´t have one without the other though. The theory is that, by deactivating the fibroblasts, the skin recovers normally, so without the scar tissue but with the sweat glands, hair follicles etc. Really excited to see his results, as well as for the dr. Barghouthi´s second trial of course.

It is unfortunate that the second trial takes longer than expected to start, of course I would like to see it happening as soon as possible too, but that is just life. Things get in the way, people get sick etc. Let's not dwell on that for too long. I also think it is reasonable to wait a couple of weeks on the input of dr. Longaker. If he has pointers on the dosage, delivery method or anything else that could influence the results, that would be well worth the waiting time. It would be a shame to start now and find out that the trial could have been better by waiting a bit longer on the information of the doc. I would like to mention again that an evaluation of the current status of the original patient seems very valuable to me. Is there any possibility to do a follow-up with him?

I am not able to tell. Would, if true, this finding impact the preliminary conclusion about the effectiveness of the doses?

Great, this guy is actually passionate about the experiment instead of "ok, ok, I'll try it". Also very positive that he is in contact with dr. Barghouthi. Is there a date known that he will make his first evaluation? Missed that from the video

Please read the full sentence, it says "to an outsider". Most people don't care to get that deep into a hairloss-cure. To them, it is the next flashy thing with supposedly incredible science behind it, just never to be heard of again. I personally do have faith in verteporfin, I think the results of the initial trial deserve a follow-up. Happy to see that coming, let's wait and see what they will bring.

Let´s be honest. At this point, the community still has difficulty in convincing its' own insiders (Mohebi, Rassman, Bisanga etc.) of verteporfin. To an outsider, this is most likely just hair loss "cure" #4578 where the previous 4577 attemps failed. Besides that, I don't think the backing of a Musk or Rogan would be necessary or even positive. There are already trials taking place that will in a rather short term show whether there is potential for further research. In that case, more (reputed) surgeons like those mentioned will be open to trials. If a beneficial effect of verteporfin exists, it will be found thanks to the advocacy of this community (especially Melvin). Let's say it works to a degree and Rogan promotes it. Many people will want it and with the small supply of verteporfin, prices will skyrocket and actually getting the stuff will be harder.

I know I have mentioned it already several times, but is there a possibility to check the original patient on his current state? If the test sites visually still look much better than the control sites, that would be a nice indication that the treatment works and passes the test of time. It's not scientific in the way people like dr. Mohebi would like to see, but still valuable I guess. What do you think about it?

That is what I would like to know as well!

This thread is close to celebriting its' anniversary. I am super curious whether the (visual) gains that the original patient seemed to have made are still there. Are there follow-ups planned with him?

Yes all of it! Especially dosages, wether it’s FUE or FUT, and yes results as well. Great work! A while ago, a backer donated around 15.000 to fund a trial. Has that trial already begun?

Thanks. Might it be worthwhile to document all the specifics, such as dosages, application methods, results assessments, timelines, future steps etc?