ATP4Hair

Hi Etownone, The ATPv spray you received is not saline or water, but is composed of lipids vesicles containing ATP (adenosine-5'-triphosphate). If you need additional amounts, you should contact Dr. Dorin and he should be able to get you an additional bottle. Just curious, you should be able to get at least 5-7 days of sprays from the bottle. Spray only enough to saturate the areas instructed by the physician. If you need any additional help or have other questions please let me know.

I certainly think Ray Konior is a great physician, but Bob Haber has a number of credentials that sets him apart from the field. Past President, Board Member, and various committees for the ISHRS Maintains clinical appointments and active in research Past editor of Hair Transplant Forum Prolific Inventor Selected top physician by ISHRS and he has performed thousands of HRS, with great patient satisfaction

I would suggest you check into Dr. Makani in Mumbai. He uses the most up to date solutions and methods for hair transplantation.

tim4d, Shock hair loss is not caused by weak hair, but hair follicle that have been traumatized by the ischemic (decreased blood flow) time the grafts experience. When the hair follicle grafts are remove from the body, they immediately experience ischemia, and this leads to significant decreases in intracellular ATP. The hair follicle cells will undergo metabolic rearrangement to conserve ATP, and will also begin using salvage pathways to create ATP from other high energy phosphates, namely AMP. As the ischemia continues, adenosine is converted to inosine, then to hypoxanthine. Hypoxanthine in the presence of oxygen, results in the formation of reactive oxygen species (ROS) and nitric oxide. If the ischemia is short,, then cellular antioxidants (e.g., glutathione, Vit A&E) will stop the destructive effects of the ROS. If the ischemia continues, the ROS build-up will cause cellular damage leading to release of inflammatory mediators (e,g, TNF-a, IL-1, bradykinin) that cause neighboring cells to potentially enter into apoptosis. The inflammation also causes tissue pressures to rise due to the leakage of serum proteins from the microvasculature. This leads to decreases in oxygen tension around the ischemic tissue, leading to further losses in intracellular ATP. Some cells of the hair follicle, namely the stem cells resident in the dermal papillae, inner root sheath, and near the epidermal/dermal border, are more resilient to ischemia. This, in part, explains why transplanted hair follicles that are poorly stored, and experience significant ATP loss, can regenerate a hair follicle and shaft. My suggestion is to ask your transplant physician how he/she deals with combating graft storage ischemia and post-operative ischemia in their practice.

Spartan 13: Shock hair loss as you describe it is a common event in the first few weeks to several months after HRS. Most physicians suggest that you not be alarmed as the transplanted follicular units can often regenerate a terminal hair within 1 year after surgery. However, just because shock hair loss is "normal" does not mean it is necessary as part of the HR procedure. The use of LLLT prior to or after HRS is, IMHO, not advisable for a variety of reasons. First, while LLLT was approved for topical uses, its impact on hair growth and follicle viability is at best sketchy, and the use of LLLT for this reason amounts to nothing but "smoke in mirrors." As you may know, the purpose of LLLT is to excite the mitochondrial electron transport chain to create ATP. While this has been proven true, the result that is often not mentioned is that LLLT produces reactive oxygen species (ROS). ROS can create an inflammatory state as a result of the damage done by the ROS on cells of the scalp. Second, the recommended usage of LLLT is 3-4 times a week for 5 min. Our body's cells collectively uses our body weight in ATP/day. A 5 min application of LLLT is not going to overcome the ischemia the follicles are subject to for the 3-5 day period prior to restoration of normal blood flow to the follicle. The major issue in shock hair loss manifests itself in this critical 3-5 day period as the level of intracellular ATP remains well below normal intracellular levels (~ 1-5 mM). A shift in adenine nucleotide levels from ATP to ADP, and AMP lowers the cellular energy charge (see Daniel Atkinson, Biochemistry , 1968, 7 (11), 4030). During severe ischemic periods, the intracellular ATP levels can drop significantly from a value of ~0.9 to well under 0.6, resulting in an energy charge that is more conducive to apoptosis (cell death) rather than cell survival. Thus keeping intracellular ATP levels of transplanted hair follicles near normal during the post-operative period is paramount to graft viability.

There have been several studies, one conducted by Dr. Beehner, that demonstrated a significant difference between the viability of saline stored vs ATPv stored grafts. There have also been other studies conducted by Dr. Cooley and Dr. Parsley showing denser re-growth. The actual number of follicles that are viable as a result of the procedure is going to vary from doc to doc, but based on our user group feedback to be around 10%. So, in a "typical" HRS you have ~ 1850 grafts x 2.5 surgical procedures = 5159 grafts x 10% = ~560 grafts.

Hi KD2020, Imagine that you are going to receive a liver transplant and you inquired as to how the procedure was going to be conducted. You learn that the transplant team has decided to cut-costs and instead of using say University of Wisconsin (UW) Solution (ViaSpan) that they were going to isolate and transport your donor liver in normal saline. You do a little research and you find out that UW solution, when compared to saline preservation, yields a 90%+ successful liver transplant rate while the saline preserved livers have a 10% success rate. You do a little more research to find out why UW is superior to saline and you find out that it boils down to mainly maintaining intracellular ATP levels and preventing reactive oxygen species formation. Needless to say you are disturbed as to why the transplant team wants to use saline. The good news is that no cell, tissue, or organ preservation expert/team would ever use a sub-standard preservation method, because they want the best possible outcome. Successful hair transplantation should absolutely be NO different from any other tissue preservation method. As soon as the doctor removes the hair follicles (follicular units) from the scalp, there is an immediate drop in blood flow, oxygen and ultimately ATP. Any solution that can help maintain intracellular ATP levels (e.g., HypoThermosol, UW, Euro-Collins, KPS, and ATPv) is going to combat the loss of ATP, and prevent cell damage/death. Is this type of thinking "Mumbo Jumbo" or is this actually how all HRS should be conducted? If I were paying $4-9/FU, I would want the surgeon to do everything possible to make sure my implants had the best success of survival. Or maybe it is some of the docs who use saline or substandard preservation technology that want you to get more implants to achieve their desired outcome...

Dear Moderator, I apologize for the post and will refrain from any commercial suggestions.

Please contact us for ordering information at: **promotional content removed by moderator**

To All Who Have Inquired: The liposomal ATP (ATPv) is currently available in the US, UK, Canada, Germany, Australia, and Turkey. If your hair transplant physician does not currently use ATPv, you can have them contact us directly for ordering information. You can also contact us directly and we can work with you and your physician in getting the ATPv available for your next upcoming operation. Best Regards, Energy Delivery Solutions (812) 920-0596 info@energy-delivery-solutions.com

Dear All, In accordance with a request from the website administrator I would like to provide you all with my contact information and website link: Dr. William Ehringer Founder and CEO Energy Delivery Solutions 3315 Industrial parkway Jeffersonville, IN 47130 p: 812-920-0596 f: 812-725-9018 Energy Delivery Solutions - Home Page

ATP is a potent vasodilator that increases dermal blood flow if it can penetrate through the epidermis into the dermal blood vessels. So, for those who do not know, ATP is rarely seen outside of our cells. When it is around, even at micromolar concentrations, it binds to purinergic receptors that are on nearly every cell in your body. The binding of ATP to these purinergic receptors causes changes in membrane potential. In our dermal blood vessels, specifically the A1-A3 arterioles, the ATP binding causes smooth muscle cell relaxation, and thus vasodilation of these arteriole beds. So why is this important in hair growth? As we age, the number of mitochondria available to make ATP decreases, leading to significant changes in the metabolism of actively dividing tissues, such as a hair follicle. Keeping scalp blood flow at levels that maintain the actively dividing cells of a hair follicle is the premise behind Minoxidil. In short: Increased Scalp Blood Flow=Greater potential to make ATP

I am not a physician, but have been involved in medical research for 20 years as a professor at the University of Louisville School of Medicine. My research studied ATPv in wound healing, organ preservation, limb preservation, cyanide poisoning, and hemorrhagic shock, most of which was funded by the NIH.

Currently, ATPv is only available through your physician. If you are looking for a physician who uses ATPv during their hair restoration procedures, please email me and I will assist you off-line. Email: bill.ehringer@energy-delivery-solutions.com

In 2002, I was studying hypothermic heart preservation and methods to increase organ holding times by increasing intracellular ATP. I then developed a fusogenic lipid vesicle delivery system that could deliver ATP to cells at rates sufficient to keep the cells alive during periods of prolonged ischemia or hypoxia. We conducted cell, tissue, organ and whole organism studies on how ATP delivery may be used in a variety of pathophysiological conditions (4 NIH funded proposals). The solution we coined VitaSol (now called ATPv) delivers ATP and we showed significant improvements in a variety of pre-clinical studies. It is now the subject of study in wound healing, hemorrhagic shock, and of course hair transplantation. The ATP delivery system (US Pat# 7,056,529) was initially studied by Dr. Jerry Cooley. He began experimenting with ATPv in 2005 and began reporting results on the HRS outcomes soon thereafter at the annual ISHRS meetings. You can search the meeting abstracts for results. Dr. Michael Beehner then studied the use of ATPv in a prolonged hair graft storage session that was reported in the Hair Transplant Forum. I presented my research in the 2010 ISHRS meeting in Anchorage as the invited Norwood Lecture. Since then, I have been involved with various symposiums organized by members of the ISHRS. I am not at liberty to disclose the 41 ATPv users, but here is a brief list of users who have agreed to disclosure: Dr. Jerry Cooley Dr. John Cole Dr. Robert True Dr. William Parsley Dr. Jennifer Martinick Dr. Carlos Puig I trust the foregoing information will answer some questions.

You should keep unused product refrigerated if possible, and use the product as directed by your physician. There are no known issues with continued spraying past the prescribed date.

The simple answer to your questions is YES to all. We are seeing less shock hair loss, increased hair density, and increased healing around the transplanted hairs. While we are still trying to understand the mechanism(s) that are responsible for these results, our in vivo and in vitro studies point to maintenance of intracellular ATP levels.

The need for cells to have ATP during the graft holding period and after the implantation is important. You are right, there are many cases where ATP was not used and the outcome was good. Why, well for one thing hair follicles contain a plethora of stem cells that can regenerate a hair follicle, and these cells are fairly resilient to prolonged ischemia. So, even using saline as a graft holding solution and no post-operative treatments many hair follicles will begin to grow hair shafts. Another important consideration is that scalp blood flow varies with age, diet, and a myriad of other factors, which can lead to different outcomes. So, if you are looking at a $15,000 operation and you want an insurance policy against non-viable follicles or shocked follicles consider the use of the ATP as a means to combat this problem.

I am the inventor of the technology, and the current supplier to 41 hair restoration clinics throughout the world.

All wounds (including transplanted hair) are ischemic (decreased blood flow), and when you make a lot of wounds, such as in HRS (i.e., 2000 wounds in the scalp), the tissue looses ATP from the lack of oxygen. Thus, the need for ATP during hair restoration procedures is a very important consideration that makes the difference between a poor outcome and a good outcome. Why is ATP important in HRS? Simple, when the physician removes your hair follicles from your scalp they are immediately cut-off from the blood that was delivering oxygen and nutrients to the hair follicle cells. During this ischemic period, the hair follicle cells begin to lose intracellular ATP, which if left uncorrected, results in death of the hair follicle cells. In many procedures, the ischemic time can exceed 4 hrs from removal to implantation, which results in significant loss of viable hair follicle cells. The end result of this outcome are either non-viable hair follicles or "shocked" follicles that may take months to a year to regrow a hair shaft. However, that is not the end of the story. When you go home from the transplant procedure, the implanted follicles are still without a source of blood flow and remain ischemic until angiogenesis (formation of blood vessels) is complete, which can be from 3-5 days. This period of ischemia also results in loss of viable hair follicle cells and invariably death of some implanted follicles. Cutting edge hair restoration surgeons are beginning to understand this as evidenced by the increasing adoption of graft holding solutions and post-operative treatment regimens that address ATP loss.