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magalh????es

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Posts posted by magalh????es

    Propecia

    in Hair Loss Drugs

    Posted

    I have never bought Proscar in local pharmacy because I usualy buy on internet. But if you are between 20-30 years old does your doctor give you a prescription for Proscar without problems?

    Propecia

    in Hair Loss Drugs

    Posted

    Hello Bill. I have ordered two times from Medstore and the last time was from 4rx because they have a lower price for generic finasteride. I had no problems with both. From Medstore, on the second order, I have received a generic version of finasteride called FiMpecia. I know some people strange this name because they know FiNpecia and think FiMpecia is not reliable finasteride. All I can say is that I used FiMpecia for one year with the same results that I had with original Propecia (6/7 years) but with much lower price. But from Medstore I would only buy generic Proscar (5 mg finasteride) because 4rx has a lower price for finasteride 1 mg. So I had no problems with delivery and quality of the products I have bought from 4rx and Medstore. But I am not selling anything!!! This is just my opinion of two more valid options to buy generic medication.

    Propecia

    in Hair Loss Drugs

    Posted

    hairhunting,

    I don?‚??t know if Bill let me write the name of the sites... But I usually buy from 4rx and medstore.

     

    Generic Finasteride ($175.00 for one year supply)

    http://www.4rx.com/main.php?Page=Product&Id=18&kbid=6979

     

    Generic Proscar ($116.70 for more than one year supply - 90+18 pills) Don?‚??t forget to cut in four parts!!!:

    http://www.medstore.biz/prescriptions/proscar/?fid=5144

     

    But there are thousands of places to buy... only some are reliable

    look wat i found-

    in Hair Loss Drugs

    Posted

    Hairdude83:

    Provillus is an another natural hair loss product like Advecia or Hairscript. Identical composition but the last one is a little expensive. Results are moderate/good. Hair looks thicker, no side effects. Finasteride (Propecia)is better but with some sides. If I were you I would start with Provillus, Advecia or Hairscript in combination with topical Minoxidil 5%. If your hair loss don't stop you can switch to Propecia

    I'm looking for some hair loss drug feedback

    in Open Hair Loss Topics

    Posted

    My classification (1-10):

    (My current regime is 1,2,3,5,6)

     

    1 - Finasteride: 9 (7 years)

    2 - Minoxidil: 8 (5 years)

    3 - Provillus (natural): 7 (1 year)

    4 - Revivogen: 6 (1 year)

    5 - Nizoral 2%: 6 (5 years)

    6 - Ecophane (multivinaminic): 6 (3 years)

    7 - Folligen: 5 (1 year)

    8 - Aminexil (Dercos): 5 (6 months)

    9 - Proxiphen-N: 4 (over priced!) (1 year)

    Finasteride Questions

    in Hair Loss Drugs

    Posted

    FINASTERIDE AND BIRTH DEFECTS

     

    There are very few more anxiety provoking times in anyone's life than possibly causing a birth defect in one's own unborn child. So, it's quite understandable that the mention of a possible birth defect with the use of finasteride (Propecia 1mg and Proscar 5mg, Merck) would cause considerable anxiety and concern. The package insert for Proscar states under the section on Contraindications: "Because of the ability of Type II 5alpha reductase inhibitors to inhibit the conversion of testosterone to DHT, finasteride may cause abnormalities of the external genitalia of a male fetus of a pregnant woman who receives finasteride". So, is the risk real? Theoretically, yes. Practically, no.

     

    The specific birth defect that can be caused by the absence or inhibition of the Type II 5-alpha reductase enzyme in the male embryo is hypospadias. Hypospadias is a birth defect in which the urinary tract opening is on the ventral surface (under side) of the penis rather than at the tip of the penis. There have never been congenital abnormalities observed in female fetuses at any dosage of finasteride.

     

    During the research and development phase of finasteride, studies were done on experimental animals. Rats, rabbits, and rhesus monkeys were given finasteride to determine its relationship to birth defects, i.e. hypospadias.

     

    Hypospadias did occur in the male offspring, when pregnant rats were administered finasteride equivalent to 5-5000 times the amount of recommended for men in treating MPB (1mg/daily). The critical period during which these effects can be induced in male rats was determined to be during the 16th ??“17th days of gestation.

     

    In rabbit fetuses exposed to finasteride in utero from days 6-18 of gestation at doses equivalent to 5000 times the recommended human dosage, no evidence of malformations was observed. This result would be expected, since there was no exposure during the critical period of genital system development in rabbits.

     

    When pregnant rhesus monkeys were given intravenous finasteride at a level equivalent to at least 750 times the highest estimated exposure of pregnant women to finasteride from semen of men taking 1mg/day, there were no genital abnormalities observed.

     

    In the human embryo, the sensitive period of external genitalia development is during the 7th - 9th weeks of gestation. Although the chromosomal and genetic sex of an embryo is determined at fertilization by the kind of sperm, either Y-bearing or X-bearing, that fertilizes the ovum, male and female morphological characteristics do not begin to develop until the seventh week. Prior to this time, the genital systems of the two sexes are similar, and the initial period of genital development is referred to as the ??indifferent state of sexual development'. About six weeks after conception, if a Y chromosome is present in the embryo's cells (as it is in normal males), a gene on the chromosome directs the undifferentiated gonads to become testes. If the Y chromosome is not present (as in normal females), the undifferentiated gonads will become ovaries. If the gonads become testes, they begin to produce androgens, primarily testosterone, by about eight weeks after conception. These androgens stimulate development of the one set of the genital ducts into the epididymes, vas deferens, and ejaculatory duct. The presence of androgens also stimulates development of the penis and the scrotum. Hypospadias can result if there is inadequate production of androgens by the fetal testes.

     

    Since the sensitive period of development of the external genitalia in the human embryo is the 7th to 9th weeks of gestation, there can be no danger to the child if the father is taking finasteride at the time of conception. Originally, Merck decided to err on the side of caution and warned against the possible problem of finasteride transfer in semen. This warning has since been removed from the package insert. Considering the medical/legal implications of a theoretically possible link of finasteride treatment to birth defects, it is reasonable to assume that Merck & Co. must be very confident in knowing that impregnating a woman while taking finasteride absolutely does not cause birth defects.

     

    Nor is there any evidence of birth defects when the father taking finasteride has intercourse with the pregnant mother during the critical periods of sexual development. The in utero effects of finasteride exposure during the period of embryonic and fetal development (gestation days 20-100) were evaluated in the rhesus monkey, a species fairly predictive of human development. Intravenous administration of finasteride to pregnant monkeys at doses as high as 800ng/day (at least 60 to 120 times the highest estimated exposure of pregnant women to finasteride from semen of men taking 5mg/day) caused no abnormalities in male fetuses.

     

    Still, Merck retains this admonition: "Women should not handle crushed or broken Propecia tablets when they are pregnant or may be potentially pregnant because of the possibility of absorption of finasteride and the subsequent potential risk to a male fetus. Propecia tablets are coated and will prevent contact with the active ingredient during normal handling, provided that the tablets have not been broken or crushed."

     

    Considering that intravenous administration of finasteride to pregnant experimental animals during the critical periods of sexual development didn't cause birth defects, there is no reason to believe that transdermal absorption of finasteride from handling broken tablets could cause birth defects in the male child. But, since Propecia has not been approved by the FDA for use by women, Merck has nothing to lose by retaining this warning. In fact, it has good p.r. value.

     

    So, can finasteride cause birth defects? Yes, there is a theoretical possibility that it can, but the probability is close to nil, when finasteride is taken in the recommended dosages. Since Propecia was approved by the FDA on 22 December 1997 and Proscar on 28 August 1996, millions of doses of finasteride have been taken and there has not been a single case report of a birth defect. Now that's reassuring information.

     

    Richard Lee, M.D.

     

     

    Andersson, S.; Berman, D. M.; Jenkins, E. P.; Russell, D. W.: Deletion of steroid 5-alpha-reductase 2 gene in male pseudohermaphroditism. Nature 354: 159-161, 1991

    Greene, S. A.; Symes, E.; Brook, C. G. D.: 5-Alpha-reductase deficiency causing male pseudohermaphroditism. Arch. Dis. Child. 53: 751-753, 1978

    Imperato-McGinley, J.; Gautier, T.: Inherited 5-alpha-reductase deficiency in man. Trends Genet. 2: 130-133, 1986

    Moore, KL and Persaud, TVN: Before We Are Born-Essentials of Embryology and Birth Defects; 6th Edition, Saunders 2003

    New England J of Med: 1994, Jan 13; 330 (2) 120-5

    Physicians Desk Reference, 58th Edition, 2004, pp. 2172-2178

    Thigpen, A. E.; Davis, D. L.; Milatovich, A.; Mendonca, B. B.; Imperato-McGinley, J.; Griffin, J. E.; Francke, U.; Wilson, J. D.; Russell, D. W.: The molecular genetics of steroid 5-alpha-reductase 2 deficiency. J. Clin. Invest. 90: 799-809, 1992

    http://encarta.msn.com/encyclopedia_761580700/Human_Sexuality.html#endads

    http://science.howstuffworks.com/human-reproduction5.htm

    Sex-organ development is determined by the third month of development.

    http://www.people.virginia.edu/~rjh9u/sexdev.html

    http://www.lindasy.com/cgi-local/SoftCart.100.exe/skin4...dec01.html?E+scstore

    Propecia - inexpensive & reliable

    in Hair Loss Drugs

    Posted

    You don?‚??t need any prescription. I can?‚??t say if you can get cheaper in other site because there are thousands of sites selling these products. But I have never seen cheaper than this and I have already seen plenty of sites. And I have never had any delivery problems.

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