I hope that, because they are synchronized, they will not fall out all at the same time when it comes the telogen phase 🫣

5 hours ago, TRC79 said:

How's everyone doing result wise? I feel like im losing ground using topical dut 3x weekly. Still on daily minox and once weekly microneedling , my best results were on oral fin .33mg 3x daily plus minox/microneedling, but had sides. So far with xyon topical dut no noticeable sides. so frustrating considering going back to oral fin maybe .25mg, really wish you could get a fin pill at a lower dose instead of cutting because its highly in accurate.

What sides ?

Photos of progression under exosomes

== +18 weeks progress (4,5 months) ==

Top view, just after exosome treatment -the hair is soaked by the product :

View from above, after the shampoo and towel-dried but still wet hair the next day :

My current notes about supplement for hair loss which I update regularly when I see information on this topic :

• For inhibition of DKK1 (DKK1 induce abnormal Wnt/beta-catenin pathway):
  • Ginko (120-240 mg/day) - do not take ginko it if you take anticoagulant medication
  • Ginseng (200-600 mg/day) - do not take ginseng if you have high blood pressure
  • Minoxidil
• For increase of blood pressure:
  • L-Carnitin (500mg - 3g / day) - do not take if you are epileptics
  • L-Citrulin (3-6g /day) - do not take if you have urea disorder or renal failure
  • Minoxidil
• For intake of vitamins:
  • All VitB (included Biotin + Pyridoxin) exept Vit E (some say Vit E supplementation can induce cancer)
• For Vitamin D pathway:
  • Vitamin D (1000 UI/day)
• Anti-oxydant against oxydation of Outer Root Sheath of the hair follicule by DHT:
  • Resveratrol (100-500mg/day) - do not take ginko it if you take anticoagulant medication or are low blood pressure
  • N-Acetyl-Cystein (NAC) + Glycin = GlyNAC => Help glutahtione production by the liver
  • Omega 3 (2g/day)
  • Zinc (10-15 mg/day)
  • Magnesium (about 400mg / day)
  • Pumpkin Seeds
  • Neetle Leaf (500mg/day) - do not take high dose if you have renal failure
  • Quercetin (500-1000 mg/day) - taking it for too long time can induce mild kidney problems
  • Fisetin (100mg /day) - do not take it if you take anticoagulant medication or take medication for high blood pressure
  • NMN (500-1000g / day)
  • Melatonin (topical 0.0033%) - do not take it if you are depressed, diabetic, epileptic or hepatic
• For decreasing DHT in blood :
  • 640mg Saw Palmetto + 8mg Astaxanthin => Decrease of about 10% of DHT in blood
  • Take 3x more and you will have about 20% of DHT decrease in blood
  • Note : for comparaison, finasteride 0.05mg/day will decrease DHT by 30% so some say a decrease of 20% is not enough to get a positive impact on hairloss

 If you take finasteride and want to protect against sides :

• To protect against neurosteroid deficiency induce by finatseride :
  • PEA => increase allopregnanolone neurosteroid level (1g/day)
  • Melatonin 
• To protect against increase of estrogen induce by finasteride by inhibiting aromatase (aromatase is the enzyme wich convert Testosterone into Oestradiol) :
  • Resveratrol
  • DIM (100mg/day)

Imo they are terminals and they will grow. Vellus hair are frizzly and not straight like yours

Concerning gyno...

Isn't it rather because finasteride blocks the conversion of testosterone into DHT that people taking fina have an increase in testosterone, which can result in an increase in estradiol levels?

Testosterone not only produces DHT but also estrogen... and therefore as the conversion to DHT is blocked, the estrogen level increases... The conversion of testosterone into DHT is done by aromatization, so aromatization inhibitors such as aromasin are required.

Adding testosterone will amplify estrogen production and gyno ...

For other sides like anxiety or depression some say that its because finasteride decrease neurosteroids in brain like allopregnanolone ... some say supplement like PEA can help to increase allo level.

There is this study which concludes :

Quote

PRP in combination with topical redensyl, saw palmetto, and biotin is a more effective treatment than PRP in combination with topical Procapil

... ?

 @bobbleboy imo there is an improvement from 28 june to 4 septembre :

Any new progress pics ? 

Great job 

Update at +3,5 months : No full head of hair but still on it 😅

I would like to take this opportunity to share with you two very interesting new videos dated from May 2023 on exosomes I recently discover if this subject interests you:

• The first one (with a delicious French accent 🤣) talk about Extracellular vesicles (Exosomes) characterization and therapeutic potential ; very very interesting ! for example, they talk about the difference between stem cell and exosome treatments and the fact that the latter method is much safer... Talk also about Platelets...
• The second one is some Q&A about exosomes, and they speak about exosomes for hairloss... and you will see that there is no propaganda on this subject, they are rather reserved about this type of treatment for the moment...

Note: I specify that I do not know at all if exosomes work to fight against hair loss and have any interest... Personally I think that in certain cases it can be beneficial, in particular when the folicles are not dead , but I'm just reporting my experience !

<========================================================================================================>

My point of view : I think that the exosomes currently available to the general public are not yet necessarily "loaded" with specific genetic material (mi-RNA) to treat alopecia... they in fact contain a mixture of mi-RNAs including one some are beneficial and others less (see my web-site: https://suiviexo.000webhostapp.com/index-en.html ... even in exosome derivated from rose stem cell there are interessting mi-RNA wich are in stem cells from humans !)

In particular, exosomes derived from human stem cells are banned in my country and many other countries. This is the reason why we can only use exosomes from, for example, plants... but which still contain interesting genetic material for hair! 

The future is in exosome engineering: Researchers are able to "load" into exosomes specific genetic material. All that remains is to find interesting mi-RNAs to fight against alopecia (we already know a large number of them!) and make them accessible to the general public!

And of course, for the moment no scientific study has been carried out by FDA to validate the therapeutic benefits of exosomes as drugs... It will therefore still take many years to "eventually" see them arrive on the market ! At the moment, they are only available as cosmetics!

Hello,

I'm a little interested in dutasteride mesotherapy at the moment and I found a doctor who practices this in France and I will talk about that with him soon ... I could therefore ask him the question I am asking you but in the meantime I would like to have your opinion

During my research on the net, I saw on the anagenica website that it is recommended to use the product for "mesotherapy" (with microneedling 0.5-1mm) with dutasteride once a week.

However, in the associated research papers found on this same site, the use is different: once a week for 1 month, then the doses are spaced out, for example once every two weeks during the next month and then 1 dose per month and some say that then the doses can be done every 3 months (same as exosomes mesotherapy)

For those who practice dutasteride mesotherapy, what do you think of this? How do you manage the distribution of doses?

I admit that doing one dose per week seems like a lot to me because it risks attacking the scalp, right?

I think (perhaps wrongly...) that doing a mesotherapy session for example once a month should not have a negative impact on the scalp for a future transplant whereas once a week it should be more dangerous, right?

Thanks you !

NB : Concerning Anagenica, the dutasteride product cannot be injected - some have tried and got a lot of sides effect... The product they sell is only for microneedle not for injection : 

Thanks for the feed back good luck !

Good question.. bisanga implantation is 7eur and tech'bisanga is 4 EUR 😇... but tech have more exp no ?

I respond to myself. After some search on the net :

The combo at 800mg, wich seems to be 4x160mg of SP + 4x40mg of Alga Haematococcus pluvialis (=4*4mg of Asaxanthin) decrease DHT by 15%.

The same combo at 2000 mg decrease DHT by 25%

Price for good quality of SP (permixon) for 4x160mg a month is about 32EUR and for asaxanthin it is about 30EUR so for 2000mg it will be more than 100EUR wich is very expensive for a low decrease of DHT.

I gave up on the idea 🙂

6 hours ago, dba said:

Wondering if there is anyway to run a test ...on DHT levels ?

The levels vary enormously during the day so this won't give too much of a reference...

I think (just an idea to have more precise evolution reference, but to check with doctors) that the Testo/DHT ratio is easier to read and that it should decrease... 

Take a look at my levels for example:

START : about 1-2 week before first blood test
STOP : about 1-2week before last blood test

We can see that the levels vary enormously :

But the DHT/TESTO ratio has fallen significantly :

On 2/14/2024 at 3:12 AM, JoeD said:

At what point in time would you consider an FUT scar safe from significant stretching? Let’s say it looks good, pencil thin, at around 6 weeks post op? When is someone out of the Wds?

I started workout at 1 month after my FUT but my scar was very sensitive... I think you need to be very attentive to your feelings at least for 3 months...

No I think it's OK 😉

I think it's a good sign but unfortunately no one can know if hairs still on miniaturization process or not ...

15 minutes ago, GoliGoliGoli said:

What is your current topical combo? 

Topical minox, Fluridil, CosmeRNA and exosomes.

Fluridil inhibit the binding of DHT to AR, CosmeRNA disable the AR and exosomes add some vitamins + grow factors + miRNA.

I would just like to add something to lower the DHT in the scalp but the only topical treatment that seems not too agressive is Xyon dutasteride gel but it is not available in my country 😞

I am also looking to do dutasteride mesotherapy in my country which could be another solution to lower the DHT in my scalp.

@mojones Well from the first half hour after application I have prostate symptoms... I tried the duta gel parati 1% and the parati fina gel 0.01%... It's very curious I think perhaps I have an allergy to products...

For the oral finasteride at very low dose, I haven't started yet, I'm trying to find less "aggressive" oral alternatives but I don't find anything very convincing...

I thought I had a clue with the astaxanthin + saw palmetto combo but the 25% reduction in DHT in the blood is a priori too low to be interesting for the hair...

So for oral fina a priori the minimum dose would be 0.25mg EOD

In any case knowing that my current topical combo works well I wonder if taking fina is useful for me... perhaps it would be more wise for me to wait until I have hair loss to start ...I hesitate a lot! 🙂

It's known that this combo decrease a little DHT about 25% in blood (while saw palmetto do not alone - it decrease DHT only in prostate) while not increasing too much Estradiol but I don't see feedback from users :

Is 25% not too low for effictiveness for just maintain hairs ?

As I was getting sides even with 0.025% topical finasteride 3x/week (wich dcrease DHT by about 34%), maybe 25% could be interesting?

An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males

Evaluation of Resettin® on serum hormone levels in sedentary males

https://www.hairloss-research.org/astaxanthin-supplement-lowers-dht/

A Long-Term Study of the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Perimenopausal, Menopausal, and Postmenopausal Women

Thanks !

@PelazoVenAMithanks !

Hi,

1,5 years ago I took fina topical 0.025% 3x/week and started having problems after 4 months (prostatis symptoms)

Among all the doctors I saw, only one urologist told me that I was having a PFS (a doctor who also transplants hair and who is a former urologist, Doctor Mousseigne in Paris). According to others my symptoms are not related to finasteride. The last one I saw tell me my symptoms come from a pudendal nerve disorder and I therefore have medication for that, which works well.

I recently try again but after trying the liposomal gel again, I had symptoms immediately in the minutes that followed...

As I find this curious, I tell myself that perhaps I have an allergy to the product in the gel... Besides, when I put my topical minoxidil in the evening, sometimes it gives me the same effect but less intense... and not every time...

So now I am trying oral form at very low dose... According the picture below (picture is from this forum but I dont have the link), 0.1mg of oral fin daily would be enought to maintain my hair, and even got some regrow (+10 hair / cm² instead of +16 with 1mg/day).

Actually I am using topical minox +  Fluridil + CosmeRNA + Exosomes and have a good maintenance (and even some regrow with exosomes I added since 2 months) but I would like to add just a little oral fin (so I could perhaps stop CosmeRNA if I support 0.1mg fin because CosmeRNA is very expensive for the "theoretical" +7.5 hairs it gives to me ...)

I just started 0.1mg few days ago (I use a very precise scale to make my 0.1mg pieces which I put in empty capsules) 

I am also taking resveratrol + nettle leaf with my 0.1mg fin to mitigate side effect as my DHT should be decreased by about 50% even with 0.1mg.

Does anyone have any feedback on this type of take for my age ?

Thanks !

2 hours ago, BurnieBurns said:

I’m afraid it isn’t that simple if the formula has had to change due to the patent. I can confirm having received farmacia para ti formula in the past year that the ingredient list on the bottle is completely different and has also resulted in some side effects. 
For anyone with only this as an option who has a history of sensitivity to the drug, I’d recommend getting a lower concentration 

Thanks you for feed back...

Well this is all a shame then!  We just have to pray very hard that Xyon arrives in Europe soon but it has already been more than a year since they should have arrived...

On 1/29/2024 at 12:15 PM, mavigo said:

Why would you add it to the topical liquid? Couldn't you just orally take the supplemental ingredients? 

@mavigo Yes I will do that for Ginseg and ginkgo bilboa 🙂 thanks