Ethested

Hey all,

Just wanted to share a new small molecule being developed by TechoDerma medicines. They are trialing their drug TDM-105795 / TMI-105795 to treat androgenic alopecia and are currently in phase 1b after having successfully completed phase 1a, in the US.

It's a topical which works via local Thyroid Receptor beta 1 agonism.

The original research stems from Pfizer, who saw hair growth in stump-tailed macaques with such a drug. The technoderma team is also mostly ex-Pfizer.

In 2016 such a compound has also been proven to work on human hair follicles ex-vivo, by Ralf Paus.

I requested a comment from him on why his research didn't continue, and he said that it DEFINITELY should be pursued but funding and legal issues with the substance IP owner prohibited him. 

TechnoDerma Medicines Pipeline: http://tkskin.com/en/index.php?a=lists&catid=24

Phase 1 dosing announcement: http://tkskin.com/en/index.php?a=shows&catid=16&id=15

What's his price (pre graft?)?

On 12/10/2021 at 4:22 PM, gillenator said:

The most apparent risk would be shock loss with that much hair volume…if it were me, I would use cosmetics such as something like Toppik behind the hairline…you would be amazed at the result.

Yeah I guessed so..btw shock loss is usually temporary isn't it?

Nevertheless, I wouldnt want to spend more than 5k, which means turkey and after some research I didnt see any comforting transplant result regarding diffuse thinning from there. Will try other regenerative treatmens..

24, yes on min since I'm 19 and fin/dut since 22. No change in hair density whatsoever after my last big shed (at 19). Laser treatments, prp and growth factor cocktails also done. Blood tests also.

I can hide it well, one trichologist said I didn't have hair loss (stupid mfer measured density on top of the sides..)

Hello,

is a HT possible in my case?
Sides are also affected - especially above the ears, back of the head not (trichoscopy has been done).

Please note I'm not looking for a diagnosis - I have been to two reputable docs.
Density on the sparse frontal region was said to be around 90/cm^2 and actual normal hair thickness very high according to the trichoscopy.

Transplant should be behind hairline, since that one is still intact.