Senior Member Dr. Carlos Wesley Posted February 11, 2016 Senior Member Share Posted February 11, 2016 For the curious folks, here is an interesting article that describes the mechanism by which caffeine can help slow hair loss. It's inhibition of the enzyme that converts testosterone to dihydrotestosterone (DHT, or the enemy of scalp hair) is caffeine's primary benefit. Now, this doesn't mean that drinking copious amounts of espresso will stimulate hair growth. Rather it is caffeine in its topical form that can have this beneficial effect. Dr. Carlos Wesley is a member of the Coalition of Independent Hair Restoration Physicians. Link to comment Share on other sites More sharing options...
Senior Member esrec Posted February 11, 2016 Senior Member Share Posted February 11, 2016 Interesting. Have you considered a formulation for patients? What are your thoughts on topical fin? Link to comment Share on other sites More sharing options...
Senior Member matt1164 Posted February 11, 2016 Senior Member Share Posted February 11, 2016 I remember once I switched from nizoral shampoo to a caffeine shampoo and that was a terrible move. I lost so much hair it was traumatic. I wouldn't recommend caffeine shampoo to my worst enemy Link to comment Share on other sites More sharing options...
Senior Member Dr. Carlos Wesley Posted February 26, 2016 Author Senior Member Share Posted February 26, 2016 Formulations are quite popular with patients and, in many cases, they make sense. So, we certainly make them available. Topical finasteride, for example, was shown to reduce scalp DHT levels 40% more that the pill form. When they performed serum draws on that patient population, finasteride was detected in the serum of those taking the pill form, but not in those using the topical version. Dr. Carlos Wesley is a member of the Coalition of Independent Hair Restoration Physicians. Link to comment Share on other sites More sharing options...
Senior Member Dolph1969 Posted February 26, 2016 Senior Member Share Posted February 26, 2016 Where can you buy topical finasteride? is it as good as the pill form and are their side effects? Link to comment Share on other sites More sharing options...
Senior Member Stig Posted February 26, 2016 Senior Member Share Posted February 26, 2016 (edited) Formulations are quite popular with patients and, in many cases, they make sense. So, we certainly make them available. Topical finasteride, for example, was shown to reduce scalp DHT levels 40% more that the pill form. When they performed serum draws on that patient population, finasteride was detected in the serum of those taking the pill form, but not in those using the topical version. Wait, so you are saying Topical fin is proven to be more effective than the oral form? If so, why has the industry been so slow to move over to topical Fin then??? Edited February 26, 2016 by Stig Link to comment Share on other sites More sharing options...
Senior Member Dutchie Posted February 26, 2016 Senior Member Share Posted February 26, 2016 Wait, so you are saying Topical fin is proven to be more effective than the oral form? If so, why has the industry been so slow to move over to topical Fin then??? A topical Fin would be a hundred times more effective and safer than a pill. The problem is with skin penetration, Fin doesnt penetrate the dermis very well, so you need something stronger than propylene glycol. Your only options are liposomes or micelles, and they dont always work very well for every substance or chemical. I know all this because I have a tiny bit of chemistry background in my education P.S. Dr. Hasson is currently working on a topical Fin Link to comment Share on other sites More sharing options...
Senior Member thisguy1 Posted February 26, 2016 Senior Member Share Posted February 26, 2016 Wait, so you are saying Topical fin is proven to be more effective than the oral form? If so, why has the industry been so slow to move over to topical Fin then??? Also my question. Jan 2016 - 3800 graft FUT with Dr. Konior NW 5A to 6. Docs whose results I am most consistently impressed with: Konior, Cooley (FUT), Hasson (FUT), Diep (FUE) (yeah I like the zig zag). Link to comment Share on other sites More sharing options...
Senior Member thisguy1 Posted February 26, 2016 Senior Member Share Posted February 26, 2016 A topical Fin would be a hundred times more effective and safer than a pill. The problem is with skin penetration, Fin doesnt penetrate the dermis very well, so you need something stronger than propylene glycol. Your only options are liposomes or micelles, and they dont always work very well for every substance or chemical. I know all this because I have a tiny bit of chemistry background in my education P.S. Dr. Hasson is currently working on a topical Fin Ok he can't do math but he can chemistry. That's a good explanation - I think it is time for self testing with some liposomes or micelles (whatever the heck those are) on yourself Dutchie. Let us know how it works. :eek::cool: Jan 2016 - 3800 graft FUT with Dr. Konior NW 5A to 6. Docs whose results I am most consistently impressed with: Konior, Cooley (FUT), Hasson (FUT), Diep (FUE) (yeah I like the zig zag). Link to comment Share on other sites More sharing options...
Senior Member Dutchie Posted February 26, 2016 Senior Member Share Posted February 26, 2016 If Big Pharma had found a way to make a topical Fin they wouldve done so a long time ago. Problem is a topical Fin in liposomes doesnt work as well as the tablet (at least thats what I heard). Trust me, the last thing pharma wants is a pill which causes libido side-effects, they much rather have a topical version. But so far they havent been able to do it Link to comment Share on other sites More sharing options...
Senior Member thisguy1 Posted February 26, 2016 Senior Member Share Posted February 26, 2016 Formulations are quite popular with patients and, in many cases, they make sense. So, we certainly make them available. Topical finasteride, for example, was shown to reduce scalp DHT levels 40% more that the pill form. When they performed serum draws on that patient population, finasteride was detected in the serum of those taking the pill form, but not in those using the topical version. 1. In what cases would it not make sense...you wrote in many case they make sense. 2. Why is this not popularly adopted by the masses if you can get the benefit without much/most of the drawbacks 3. If Dutchie is correct what is the carrier agent for the topical fin to penetrate the scalp? Thx. Jan 2016 - 3800 graft FUT with Dr. Konior NW 5A to 6. Docs whose results I am most consistently impressed with: Konior, Cooley (FUT), Hasson (FUT), Diep (FUE) (yeah I like the zig zag). Link to comment Share on other sites More sharing options...
Senior Member thisguy1 Posted February 26, 2016 Senior Member Share Posted February 26, 2016 If Big Pharma had found a way to make a topical Fin they wouldve done so a long time ago. Problem is a topical Fin in liposomes doesnt work as well as the tablet (at least thats what I heard). Trust me, the last thing pharma wants is a pill which causes libido side-effects, they much rather have a topical version. But so far they havent been able to do it If accurate, than what is Dr Wesley delivering to his patients? He wrote it as if a portion of his patients are getting the topical fin. Someone wrote on another thread that they get topical fin from "Italy". Well there goes my hope to just crush the pill and sprinkle it on my bald spots.:cool: Jan 2016 - 3800 graft FUT with Dr. Konior NW 5A to 6. Docs whose results I am most consistently impressed with: Konior, Cooley (FUT), Hasson (FUT), Diep (FUE) (yeah I like the zig zag). Link to comment Share on other sites More sharing options...
Senior Member Dutchie Posted February 26, 2016 Senior Member Share Posted February 26, 2016 3. If Dutchie is correct what is the carrier agent for the topical fin to penetrate the scalp? Its not a carrier agent, its a "penetration enhancer" (no sex jokes please...LOL). The only effective ones I know (and please doctors, if I'm wrong you can correct me) are: 1. Propylene glycol 2. PEG400 3. Lipo's 4. Micelles There might be others, but those are the main 4 I have worked on the last 20 years or so Link to comment Share on other sites More sharing options...
Senior Member Dutchie Posted February 26, 2016 Senior Member Share Posted February 26, 2016 If accurate, than what is Dr Wesley delivering to his patients? He wrote it as if a portion of his patients are getting the topical fin. Someone wrote on another thread that they get topical fin from "Italy". Well there goes my hope to just crush the pill and sprinkle it on my bald spots.:cool: Because you might still get SOME benefit from a topical Fin. You see, some of the drug will still get through the dermis, but it might not be not as much you want. The ultimate goal is to have 100% Fin passing through the dermis and into the hair follicle Link to comment Share on other sites More sharing options...
Senior Member Indi9 Posted February 26, 2016 Senior Member Share Posted February 26, 2016 I think I have seen a topical finasteride bottle being sold at one of the local pharmacy....can't recall the brand. Will get the name and composition tomorrow. Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted February 26, 2016 Administrators Share Posted February 26, 2016 Because you might still get SOME benefit from a topical Fin. You see, some of the drug will still get through the dermis, but it might not be not as much you want. The ultimate goal is to have 100% Fin passing through the dermis and into the hair follicle Check what Dr. Hasson had to say, accordant to him it's a viable alternative for those who can't tolerate oral fin I’m a paid admin for Hair Transplant Network. I do not receive any compensation from any clinic. My comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Senior Member Dutchie Posted February 26, 2016 Senior Member Share Posted February 26, 2016 And it WOULD be an alternative to oral Fin. But from all the papers I've read, topical Fin doesnt seem to get the drug into the follicle the way it does oral Fin. Thats just what I've read. If you think topical Fin works better then please tell why hasnt BigPharma come up with an easy topical solution by now?? Finasteride was mass-produced around 1995 or so, are you guys gonna sit here and tell me they never thought of producing a topical Fin up till now, or something similar like minoxidil ??! Link to comment Share on other sites More sharing options...
Senior Member esrec Posted February 26, 2016 Senior Member Share Posted February 26, 2016 Debating the merits of big pharma is another topic entirely. With sales of Fin what they are I doubt there's much incentive to cross-sell the same drug. They would be cannablizing their own business and subsequent profits. It's all about business. That's it. Big Pharma does not care. They are also going to court this year regarding Fin and labeling issues, disconnects between information shared across different countries, and post-finasteride issue claims. We all know the 1-2% incident reference is laughable. That aside, would love to hear Dr. Wesley's feedback on the results he's seeing, and more importantly, if topical fin is a best of both worlds scenario. There's another thread that someone started recently on topical fin. I'll try and find it. Link to comment Share on other sites More sharing options...
Senior Member Dutchie Posted February 26, 2016 Senior Member Share Posted February 26, 2016 Check what Dr. Hasson had to say, accordant to him it's a viable alternative for those who can't tolerate oral fin Great!!!!!!!!! If Dr. Hasson (who I greatly respect) found a way of delivering a topical Fin that works, then all the more power to him! It wouldnt be surprised if he did. That man is a freaking genius! Link to comment Share on other sites More sharing options...
Senior Member esrec Posted February 26, 2016 Senior Member Share Posted February 26, 2016 http://www.hairrestorationnetwork.com/eve/182120-applying-topical-fin.html Link to comment Share on other sites More sharing options...
Regular Member Loki Posted February 26, 2016 Regular Member Share Posted February 26, 2016 Dr. Shapiro is reporting the same success as Dr. Hasson... And yes I agree that delivery is critical so I would only go with the compounding pharmacy that the clinics are using... I will check my label tonight for the delivery method... The things you mention on the thread earlier look familiar.. I will update soon... Link to comment Share on other sites More sharing options...
Regular Member Loki Posted February 27, 2016 Regular Member Share Posted February 27, 2016 Its not a carrier agent, its a "penetration enhancer" (no sex jokes please...LOL). The only effective ones I know (and please doctors, if I'm wrong you can correct me) are: 1. Propylene glycol 2. PEG400 3. Lipo's 4. Micelles There might be others, but those are the main 4 I have worked on the last 20 years or so Ok Dutchie I am looking at the device. It says Finasteride gel Liposomial 2.5%. If you want or need me to and can put in the entire label if that helps. Link to comment Share on other sites More sharing options...
Senior Member Dutchie Posted February 27, 2016 Senior Member Share Posted February 27, 2016 Ok Dutchie I am looking at the device. It says Finasteride gel Liposomial 2.5%. If you want or need me to and can put in the entire label if that helps If the topical Fin works for you as well as Fin tablets, then by golly stick with it Link to comment Share on other sites More sharing options...
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