I'm not sure how coffee can affect the use of that drug, but I do know that if you drink coffee, you want to go to the bathroom more often than you normally do . Also caffeine in coffee dilates blood vessels and makes blood circulation faster. I drink only fresh and only ground coffee and use the coffee machine and coffee grinder from this site helixcoffee.com . I am feeling fine and do not have any serious health problem at my 58 .