Jump to content

JesseJames

Members
  • Posts

    2
  • Joined

  • Last visited

Basic Information

  • Gender
    Male
  • Country
    Austria
  • State
    AL

JesseJames's Achievements

New Real Hair Club Member

New Real Hair Club Member (1/8)

10

Reputation

  1. they are conclusions of studies and part of the abstract. You cant take conclusions of studies out of the context, thats why they are the conclusion on the research about a specific subject. You can't just interpret it however you feel like. Its written there black on white. PFS is unfortunately quite real and the evidence is right in front of your eyes. Regarding aspirin, we should also put things in context. In terms of number, far more people take aspirin than Finasteride, so you cant really compare them like that. Its not on us to decide if propecia will be withdrawn. None of you guys can decide on that don't make it sound like you know what should be done. There are regulatory authorities that take care of this as you know. They are the ones who will know what has to be done.
  2. Mark is just telling you something that many thousands of us, and their relatives (i.e. parents of teens who took it and ended up committing suicie) already know: finasteride, among other similarly acting drugs, can cause life altering permanent side effects, not just mental but also physical, in a subset of people. An approved drug, for a cosmetic reason, should not be life shattering and a total body wide destruction for some people. many other drugs were taken out of the market or never approved for far less than what this drug causes. Legal action has been taken with 742 Propecia (finasteride) lawsuits filed against the manufacturer Merck as well... If you dont believe me just look it up: https://www.ncbi.nlm.nih.gov/pubmed/24928450/ Responses from 131 generally healthy men (mean age, 24 years) who had taken finasteride for male pattern hair loss was included in the analysis. The most notable finding was that adverse effects persisted in each of the domains, indicating the possible presence of a "post-finasteride syndrome." https://www.ncbi.nlm.nih.gov/pubmed/26763726/ the most frequent sexual symptoms referred were loss of penis sensitivity (87.3%), decreased ejaculatory force (82.3%), and low penile temperature (78.5%). The most frequent non-sexual symptoms were reduced feeling of life pleasure or emotions (anhedonia) (75.9%); lack of mental concentration (72.2%), and loss of muscle tone/mass (51.9%). We contributed to inform about symptoms of PFS patients; unexpectedly loss of penis sensitivity was more frequent than severe erectile dysfunction and loss of muscle tone/mass was affecting half of the subjects. Further studies are necessary to investigate the pathophysiological and biochemical pathways leading to the post-finasteride syndrome. https://www.ncbi.nlm.nih.gov/pubmed/28024997 This study showed that short and/or long (CAG)n and (GGN)n repeats had different frequencies according to symptoms reported by patients with PFS, likely reflecting the vast array of genes modulated by the AR. This study showed a U-curvilinear profile of (CAG)n repeats for skin dryness symptoms, where the two extremes exhibited a worse condition than medium repeats. Further studies are necessary to investigate the PFS pathophysiology using a precision medicine approach. https://www.ncbi.nlm.nih.gov/pubmed/26296373 Future studies should investigate the biochemical and physiological mechanisms that underlie the persistence of the adverse sexual side effects to determine why a subset of patients is afflicted with such persistence or irreversible adverse effects. Also a better focus of clinical research is urgently needed to better define those subjects who are likely to be adversely affected by such agents. Furthermore, research on the non-sexual adverse effects such as diabetes, psychosis, depression, and cognitive function are needed to better understand the broad spectrum of the effects these drugs may elicit during their use in treatment of AGA or BPH https://www.ncbi.nlm.nih.gov/pubmed/21176115 Prolonged adverse effects on sexual function such as erectile dysfunction and diminished libido are reported by a subset of men, raising the possibility of a causal relationship. https://www.ncbi.nlm.nih.gov/pubmed/28453908 In conclusion, present data show that the use of 5ARI significantly increases the risk of erectile dysfunction and hypoactive sexual desire in subjects with benign prostatic hyperplasia. Patients should be adequately informed before 5ARIs are prescribed. https://www.ncbi.nlm.nih.gov/pubmed/24955220 5α-Rs isoforms (types 1-3) are widely distributed in many tissues including the central nervous system and inhibition of these enzymes results in blockade of synthesis of several key hormones and neuro-active steroids leading to a host of adverse effects, including loss of or reduced libido, erectile dysfunction, orgasmic dysfunction, increased high Gleason grade prostate cancer, observed heart failure and cardiovascular events in clinical trials, and depression. Considerable evidence exists from preclinical and clinical studies, which point to significant and serious adverse effects of 5α-RIs, finasteride and dutasteride, on sexual health, vascular health, psychological health and the overall quality of life. Physicians need to be aware of such potential adverse effects and communicate such information to their patients prior to commencing 5α-RIs therapy. https://www.ncbi.nlm.nih.gov/pubmed/29224108 We also believe that physicians prescribing 5α-reductase inhibitors (i.e., finasteride or dutasteride) for relief of BPH symptoms or treatment of hair loss should engage their patients in a productive discussion regarding the potential adverse side effects of these medications on their overall health and quality of life.
  3. Welcome to our Hair Restoration Social Community and enhanced discussion forum. Feel free to customize your profile by sharing your story, creating blogs, sharing your treatment regimen, presenting your hair restoration photos, and uploading videos. You can also join groups and interact with other members via public chat and instant message those you add to your friends.

    Feel free to ask questions and interact with our members on our new and improved hair loss discussion forum.

    If there's anything I can do to help or make things easier for you, don't hesitate to send me a private message or post on my wall.

    All the Best,

    David (TakingThePlunge) – Forum Co-Moderator and Editorial Assistant of the Hair Transplant Network, the Hair Loss Learning Center, the Hair Loss Q&A Blog, and the new Hair Restoration Social Network and Discussion Forum

×
×
  • Create New...