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Old 04-25-2011, 05:31 PM
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Default Propecia- Can you have kids while on it?!

Hey Everyone...I am considering taking propecia and I know all the potential sides and other discussions...but I want to hear from everyone taking it in regards to has it hindered you from having kids? Meaning I am told if i want to have a child, to get off of it a month or so before I would try to conceive...has anyone had any issues with this. Please tell me your stories...because this scares me in that I don't want to mess around with this if it could make me infertile. Thanks!
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Old 04-25-2011, 06:17 PM
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Many guys father kids while on Propecia. Some stop it just to be real safe, but the dangers in birth defects lay in a woman handling broken Propecia tablets.
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Old 04-26-2011, 12:07 PM
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This should help you it's a email from Dr Lee i found to another forum user who knows a thing or two about these things but in short the answer is yes it is fine merck didn't do much research in the early days so had to put disclaimers on the propecia boxes.

3 years ago I sent an email to Dr. Lee (www.minoxidil.com).
"I have used propecia and Dr Lee 5% minoxidil solutions since 2001 with good results. I plan to have a child and i would like to know if i have to discontinue the use of these products."
ANSWER:
You do not have to discontinue any of them.

"On your website you say that it is recommended that its use be discontinued two weeks prior to procreative sex. The only side effect i have reported is a decrease in ejaculate volume (not in libido). My sex life has not changed at all. But i have already read on the net that the use of finasteride should be discontinued 3 months (or 6 months) prior to procreative sex. Can you please help me?"
ANSWER:
Read the attached article that I wrote recently.
Best wishes,
Richard Lee, M.D.

Fortunately I have a beautiful healthy girl, but I discontinue the use of Finasteride for 10 months


FINASTERIDE AND BIRTH DEFECTS

There are very few more anxiety provoking times in anyone's life than possibly causing a birth defect in one's own unborn child. So, it's quite understandable that the mention of a possible birth defect with the use of finasteride (Propecia 1mg and Proscar 5mg, Merck) would cause considerable anxiety and concern. The package insert for Proscar states under the section on Contraindications: "Because of the ability of Type II 5alpha reductase inhibitors to inhibit the conversion of testosterone to DHT, finasteride may cause abnormalities of the external genitalia of a male fetus of a pregnant woman who receives finasteride". So, is the risk real? Theoretically, yes. Practically, no.

The specific birth defect that can be caused by the absence or inhibition of the Type II 5-alpha reductase enzyme in the male embryo is hypospadias. Hypospadias is a birth defect in which the urinary tract opening is on the ventral surface (under side) of the penis rather than at the tip of the penis. There have never been congenital abnormalities observed in female fetuses at any dosage of finasteride.

During the research and development phase of finasteride, studies were done on experimental animals. Rats, rabbits, and rhesus monkeys were given finasteride to determine its relationship to birth defects, i.e. hypospadias.

Hypospadias did occur in the male offspring, when pregnant rats were administered finasteride equivalent to 5-5000 times the amount of recommended for men in treating MPB (1mg/daily). The critical period during which these effects can be induced in male rats was determined to be during the 16th ??17th days of gestation.

In rabbit fetuses exposed to finasteride in utero from days 6-18 of gestation at doses equivalent to 5000 times the recommended human dosage, no evidence of malformations was observed. This result would be expected, since there was no exposure during the critical period of genital system development in rabbits.

When pregnant rhesus monkeys were given intravenous finasteride at a level equivalent to at least 750 times the highest estimated exposure of pregnant women to finasteride from semen of men taking 1mg/day, there were no genital abnormalities observed.

In the human embryo, the sensitive period of external genitalia development is during the 7th - 9th weeks of gestation. Although the chromosomal and genetic sex of an embryo is determined at fertilization by the kind of sperm, either Y-bearing or X-bearing, that fertilizes the ovum, male and female morphological characteristics do not begin to develop until the seventh week. Prior to this time, the genital systems of the two sexes are similar, and the initial period of genital development is referred to as the ??indifferent state of sexual development'. About six weeks after conception, if a Y chromosome is present in the embryo's cells (as it is in normal males), a gene on the chromosome directs the undifferentiated gonads to become testes. If the Y chromosome is not present (as in normal females), the undifferentiated gonads will become ovaries. If the gonads become testes, they begin to produce androgens, primarily testosterone, by about eight weeks after conception. These androgens stimulate development of the one set of the genital ducts into the epididymes, vas deferens, and ejaculatory duct. The presence of androgens also stimulates development of the penis and the scrotum. Hypospadias can result if there is inadequate production of androgens by the fetal testes.

Since the sensitive period of development of the external genitalia in the human embryo is the 7th to 9th weeks of gestation, there can be no danger to the child if the father is taking finasteride at the time of conception. Originally, Merck decided to err on the side of caution and warned against the possible problem of finasteride transfer in semen. This warning has since been removed from the package insert. Considering the medical/legal implications of a theoretically possible link of finasteride treatment to birth defects, it is reasonable to assume that Merck & Co. must be very confident in knowing that impregnating a woman while taking finasteride absolutely does not cause birth defects.

Nor is there any evidence of birth defects when the father taking finasteride has intercourse with the pregnant mother during the critical periods of sexual development. The in utero effects of finasteride exposure during the period of embryonic and fetal development (gestation days 20-100) were evaluated in the rhesus monkey, a species fairly predictive of human development. Intravenous administration of finasteride to pregnant monkeys at doses as high as 800ng/day (at least 60 to 120 times the highest estimated exposure of pregnant women to finasteride from semen of men taking 5mg/day) caused no abnormalities in male fetuses.

Still, Merck retains this admonition: "Women should not handle crushed or broken Propecia tablets when they are pregnant or may be potentially pregnant because of the possibility of absorption of finasteride and the subsequent potential risk to a male fetus. Propecia tablets are coated and will prevent contact with the active ingredient during normal handling, provided that the tablets have not been broken or crushed."

Considering that intravenous administration of finasteride to pregnant experimental animals during the critical periods of sexual development didn't cause birth defects, there is no reason to believe that transdermal absorption of finasteride from handling broken tablets could cause birth defects in the male child. But, since Propecia has not been approved by the FDA for use by women, Merck has nothing to lose by retaining this warning. In fact, it has good p.r. value.

So, can finasteride cause birth defects? Yes, there is a theoretical possibility that it can, but the probability is close to nil, when finasteride is taken in the recommended dosages. Since Propecia was approved by the FDA on 22 December 1997 and Proscar on 28 August 1996, millions of doses of finasteride have been taken and there has not been a single case report of a birth defect. Now that's reassuring information.

Richard Lee, M.D.
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Old 04-28-2011, 03:59 PM
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wow...thanks for the article...great info in that! Does anyone else have any real life stories that they were on Propecia and actually had a child? Please share!
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Old 04-28-2011, 04:59 PM
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Forget birth defects. First question will be whether you can get an erection while on it.
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Old 04-28-2011, 11:55 PM
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I have been on the meds 10+ years, never had 1 erection issue and to add to that i fathered TWINS at the very first attempt.

I think its a fertility drug.
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Old 04-29-2011, 09:31 AM
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I've been on it for 10 years and never had erection problems.

Spex just out of interest did you stop taking it while conceiving?

Did you continue to take finasteride and have sex with her without condoms while she was pregnant?

What is the sex of your twins?

Cheers pal i'd be very interested to know.
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Old 04-29-2011, 10:25 AM
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Bonk,

Boy and Girl - hit the jackpot!!! Didnt sleep for a year but well worth it! No i didnt stop taking the drug as had already met MANY guys who had conceived with no issue so i wasnt really worried or didnt get freaked out by the urban myths.

Mate ill be honest not much sex was had as my wife was the size of a house and very uncomfortable carrying my twins and rarely in the mood.. I think we had a couple of rumbles unprotected if that helps.

Best
s
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Old 04-29-2011, 12:01 PM
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Cheers pal that's well worth knowing another persons experiance fathering.
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http://www.hairtransplantnetwork.com/blog/home-page.asp?WebID=1977

Started losing my hair at 19 in 1999
I've been using propecia and minoxidil over 12 years
Had 5 hair transplants over 11000 grafts by way of strip & fue
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Old 04-30-2011, 12:52 AM
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No worries. I can only comment on my personal experience
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