RU in particular is usually said to have remarkably little systemic absorption. Not everyone has gotten the much-hyped great results on their hair from the stuff, however I can't remember ever reading of anyone complaining about systemic effects from it. It seems to have proved a lot safer than Flutamide on this issue.


It's a risk, but it's not the worst thing I've heard of people trying for MPB. (I think I'd personally worry more about taking systemic Dutasteride than topical RU, and Dut is already legally prescribed & sold in pills.)

I've thought about trying RU myself, and I'd be very curious about what you get out of it if pursue this. I hear that the stuff is very sensitive to storage conditions. That issue may well have kept it off the mass market (impractical). Take great care with it or lose it.

There's also the dosage & vehicle issues. You'd need to have it in something that absorbs well. And the dosage is a problem too. Too much is pissing money, and too little negates the gains. There's probably a fine line between the two.

Good luck if you pursue this. Keep us posted.
Iv'e stumbled onto other MPB message boards where more people have tried this stuff in the past; you might get more informed/experienced advice poking around one of those places.


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I was just wondering if anyone is seeing results who is using this RU58841? There was alot of jargon in the article that giants provided the link to but it seems to suggest it should be used in combination with minoxidil, in which case the benefit of only applying it once a day unlike minox is negated.

I personally would steer clear of any therapy that hasn't been proven to be safe in humans. Effectiveness in a handful of animals doesn't mean it will work in humans.

Someone mentioned it won't be absorbed systemically - that's not the case at all. The drug is lipophilic - meaning it will cross the skin and be absorbed into the bloodstream.

In fact, with products like shampoos and the like, a surprising amount of active ingredient is absorbed.

If you do go ahead with an experimental drug - you risk doing more harm than good.

My advice, if you can't take Finasteride, is to look into topical finasteride. Someone mentioned on the forums recently that Hasson and Wong have a guy that compounds it for their patients who can't take the tablet. It's worth a shot.

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On Propecia since July 2008 and maintaining.

Matt, how did you accomplish this? Did you use as specific regimen?