No never. just make sure to tap the fibres of nanogen container slowly and carefully into the regular empty bottle of toppik, then fit the spray applicator on it and HERE U GO. Ready for the battle. but bare in mind when you use the toppik spray applicator or maximizer whatever they call it, make sure the bottle is always full or more than half atleast. otherwise if the content is less than half then the spray applicator will spray air instead which will push away the fibers in the scalp instead.

Nanogen is way much better than Toppik. No questions. Its just that isnt well known as Toppik because its British.